abnormal depression-related behavior Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description responses to a stressful situation or stimulus, or failure to seek pleasurable stimuli (Mammalian Phenotype Ontology, MP_0003360)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003360
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Genes

82 gene mutations causing the abnormal depression-related behavior phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADCY7 adenylate cyclase 7
ADGRB2 adhesion G protein-coupled receptor B2
ADRA2C adrenoceptor alpha 2C
AFM afamin
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CD47 CD47 molecule
CER1 cerberus 1, DAN family BMP antagonist
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CNR1 cannabinoid receptor 1 (brain)
CRHR2 corticotropin releasing hormone receptor 2
CSMD1 CUB and Sushi multiple domains 1
DGCR8 DGCR8 microprocessor complex subunit
DHRS4 dehydrogenase/reductase (SDR family) member 4
DISC1 disrupted in schizophrenia 1
DRD1 dopamine receptor D1
DUSP1 dual specificity phosphatase 1
ELMOD1 ELMO/CED-12 domain containing 1
FAM3D family with sequence similarity 3, member D
FKBP5 FK506 binding protein 5
FRZB frizzled-related protein
FZD3 frizzled class receptor 3
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GPR26 G protein-coupled receptor 26
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GSK3B glycogen synthase kinase 3 beta
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HCRTR1 hypocretin (orexin) receptor 1
HCRTR2 hypocretin (orexin) receptor 2
HMX3 H6 family homeobox 3
HNF4G hepatocyte nuclear factor 4, gamma
HPRT1 hypoxanthine phosphoribosyltransferase 1
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
IFNGR1 interferon gamma receptor 1
IL6 interleukin 6
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
MAGED1 melanoma antigen family D1
MAOA monoamine oxidase A
MED18 mediator complex subunit 18
MYSM1 Myb-like, SWIRM and MPN domains 1
NOS1 nitric oxide synthase 1 (neuronal)
NR4A2 nuclear receptor subfamily 4, group A, member 2
OPRD1 opioid receptor, delta 1
OPRM1 opioid receptor, mu 1
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAWR PRKC, apoptosis, WT1, regulator
PCDH17 protocadherin 17
PDE1B phosphodiesterase 1B, calmodulin-dependent
PDLIM5 PDZ and LIM domain 5
PEX5L peroxisomal biogenesis factor 5-like
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PTGFRN prostaglandin F2 receptor inhibitor
PTPRG protein tyrosine phosphatase, receptor type, G
RLN3 relaxin 3
S100A10 S100 calcium binding protein A10
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SFRP2 secreted frizzled-related protein 2
SIGMAR1 sigma non-opioid intracellular receptor 1
SIRPA signal-regulatory protein alpha
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLITRK1 SLIT and NTRK-like family, member 1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SPPL3 signal peptide peptidase like 3
STX1A syntaxin 1A (brain)
TAC1 tachykinin, precursor 1
TNF tumor necrosis factor
TPH2 tryptophan hydroxylase 2
TRHR thyrotropin-releasing hormone receptor
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP46 ubiquitin specific peptidase 46
ZNF175 zinc finger protein 175