abnormal common myeloid progenitor cell morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structrual anomaly of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage (Mammalian Phenotype Ontology, MP_0006410)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0006410
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Genes

83 gene mutations causing the abnormal common myeloid progenitor cell morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADAR adenosine deaminase, RNA-specific
ANK1 ankyrin 1, erythrocytic
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARID4A AT rich interactive domain 4A (RBP1-like)
ASXL1 additional sex combs like transcriptional regulator 1
ATF4 activating transcription factor 4
BRCA2 breast cancer 2, early onset
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCR2 chemokine (C-C motif) receptor 2
CD34 CD34 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CREBBP CREB binding protein
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTSG cathepsin G
CXCL12 chemokine (C-X-C motif) ligand 12
DKC1 dyskeratosis congenita 1, dyskerin
EP400 E1A binding protein p400
ERCC1 excision repair cross-complementation group 1
FANCC Fanconi anemia, complementation group C
FGF2 fibroblast growth factor 2 (basic)
FLT3 fms-related tyrosine kinase 3
FLT3LG fms-related tyrosine kinase 3 ligand
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA2 GATA binding protein 2
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
HIP1 huntingtin interacting protein 1
HMGB3 high mobility group box 3
HOXA9 homeobox A9
IFNB1 interferon, beta 1, fibroblast
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL2RB interleukin 2 receptor, beta
IL31RA interleukin 31 receptor A
IL3RA interleukin 3 receptor, alpha (low affinity)
IL6ST interleukin 6 signal transducer
JAK2 Janus kinase 2
KAT6A K(lysine) acetyltransferase 6A
KIAA0101 KIAA0101
KITLG KIT ligand
KMT2A lysine (K)-specific methyltransferase 2A
KMT2E lysine (K)-specific methyltransferase 2E
LDHA lactate dehydrogenase A
LIF leukemia inhibitory factor
LMO2 LIM domain only 2 (rhombotin-like 1)
LRFN2 leucine rich repeat and fibronectin type III domain containing 2
MECOM MDS1 and EVI1 complex locus
MEIS1 Meis homeobox 1
MPL MPL proto-oncogene, thrombopoietin receptor
MSI2 musashi RNA-binding protein 2
MXD1 MAX dimerization protein 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCKAP1L NCK-associated protein 1-like
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
OPRM1 opioid receptor, mu 1
OSMR oncostatin M receptor
PBX1 pre-B-cell leukemia homeobox 1
PKLR pyruvate kinase, liver and RBC
PLCD1 phospholipase C, delta 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBL1 retinoblastoma-like 1
RUNX1 runt-related transcription factor 1
SAC3D1 SAC3 domain containing 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLX4 SLX4 structure-specific endonuclease subunit
SOD1 superoxide dismutase 1, soluble
SOS1 son of sevenless homolog 1 (Drosophila)
SPI1 Spi-1 proto-oncogene
STAT1 signal transducer and activator of transcription 1, 91kDa
TAL1 T-cell acute lymphocytic leukemia 1
TET2 tet methylcytosine dioxygenase 2
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TP53 tumor protein p53
TRIB1 tribbles pseudokinase 1
TSTA3 tissue specific transplantation antigen P35B
TYK2 tyrosine kinase 2
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
ZFPM1 zinc finger protein, FOG family member 1