abnormal circulating triglyceride level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description abnormal concentration of naturally occurring esters of three fatty acids and glycerol in the blood; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver (Mammalian Phenotype Ontology, MP_0011969)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0011969
Similar Terms
Downloads & Tools

Genes

243 gene mutations causing the abnormal circulating triglyceride level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
ABHD5 abhydrolase domain containing 5
ACACB acetyl-CoA carboxylase beta
ACOT11 acyl-CoA thioesterase 11
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR2 adiponectin receptor 2
AEBP1 AE binding protein 1
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AGRP agouti related neuropeptide
AHSG alpha-2-HS-glycoprotein
ALDH16A1 aldehyde dehydrogenase 16 family, member A1
ALMS1 Alstrom syndrome protein 1
ALPI alkaline phosphatase, intestinal
ANGPTL3 angiopoietin-like 3
ANGPTL4 angiopoietin-like 4
ANKRD26 ankyrin repeat domain 26
APC adenomatous polyposis coli
APOA1 apolipoprotein A-I
APOA4 apolipoprotein A-IV
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOC1 apolipoprotein C-I
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APOF apolipoprotein F
APOM apolipoprotein M
AQP3 aquaporin 3 (Gill blood group)
AQP8 aquaporin 8
AQP9 aquaporin 9
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARRDC3 arrestin domain containing 3
BAG3 BCL2-associated athanogene 3
BGLAP bone gamma-carboxyglutamate (gla) protein
BRD2 bromodomain containing 2
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C19ORF80 chromosome 19 open reading frame 80
C3 complement component 3
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CAPZB capping protein (actin filament) muscle Z-line, beta
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX6 chromobox homolog 6
CD36 CD36 molecule (thrombospondin receptor)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEP19 centrosomal protein 19kDa
CES1 carboxylesterase 1
CHRM3 cholinergic receptor, muscarinic 3
CIDEA cell death-inducing DFFA-like effector a
CIDEB cell death-inducing DFFA-like effector b
CIDEC cell death-inducing DFFA-like effector c
CISD2 CDGSH iron sulfur domain 2
CLOCK clock circadian regulator
CLPS colipase, pancreatic
CNOT3 CCR4-NOT transcription complex, subunit 3
COL18A1 collagen, type XVIII, alpha 1
CPE carboxypeptidase E
CPT1C carnitine palmitoyltransferase 1C
CRH corticotropin releasing hormone
CRHR2 corticotropin releasing hormone receptor 2
CRTC1 CREB regulated transcription coactivator 1
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTH cystathionine gamma-lyase
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DGAT1 diacylglycerol O-acyltransferase 1
DGAT2 diacylglycerol O-acyltransferase 2
DLL1 delta-like 1 (Drosophila)
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DUSP1 dual specificity phosphatase 1
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ELMOD1 ELMO/CED-12 domain containing 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FABP3 fatty acid binding protein 3, muscle and heart
FABP4 fatty acid binding protein 4, adipocyte
FABP6 fatty acid binding protein 6, ileal
FAM117B family with sequence similarity 117, member B
FFAR1 free fatty acid receptor 1
FGF21 fibroblast growth factor 21
FGF23 fibroblast growth factor 23
FOXA1 forkhead box A1
FOXA2 forkhead box A2
FOXO1 forkhead box O1
FTO fat mass and obesity associated
G6PC glucose-6-phosphatase, catalytic subunit
G6PC2 glucose-6-phosphatase, catalytic, 2
GALC galactosylceramidase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCK glucokinase (hexokinase 4)
GHR growth hormone receptor
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAS GNAS complex locus
GPAM glycerol-3-phosphate acyltransferase, mitochondrial
GPIHBP1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
GPR26 G protein-coupled receptor 26
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GSTK1 glutathione S-transferase kappa 1
HADH hydroxyacyl-CoA dehydrogenase
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HNF4A hepatocyte nuclear factor 4, alpha
HPN hepsin
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IGFBP3 insulin-like growth factor binding protein 3
IL21R interleukin 21 receptor
IL25 interleukin 25
INPP5K inositol polyphosphate-5-phosphatase K
INPPL1 inositol polyphosphate phosphatase-like 1
INS insulin
INSIG1 insulin induced gene 1
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KDM3A lysine (K)-specific demethylase 3A
KISS1R KISS1 receptor
KLB klotho beta
KMT2B lysine (K)-specific methyltransferase 2B
LAMB2 laminin, beta 2 (laminin S)
LCAT lecithin-cholesterol acyltransferase
LDLR low density lipoprotein receptor
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LEP leptin
LEPR leptin receptor
LIF leukemia inhibitory factor
LIPC lipase, hepatic
LIPE lipase, hormone-sensitive
LIPG lipase, endothelial
LIPI lipase, member I
LMF1 lipase maturation factor 1
LMNA lamin A/C
LPIN1 lipin 1
LPL lipoprotein lipase
LYPD3 LY6/PLAUR domain containing 3
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK4 MAP/microtubule affinity-regulating kinase 4
MC3R melanocortin 3 receptor
MECP2 methyl CpG binding protein 2
MFSD2A major facilitator superfamily domain containing 2A
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MGLL monoglyceride lipase
MIA2 melanoma inhibitory activity 2
MIR122 microRNA 122
MIR378A microRNA 378a
MOGAT2 monoacylglycerol O-acyltransferase 2
MSTN myostatin
MTTP microsomal triglyceride transfer protein
MUC2 mucin 2, oligomeric mucus/gel-forming
MYO7A myosin VIIA
NCOA3 nuclear receptor coactivator 3
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NKX2-3 NK2 homeobox 3
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR2C2 nuclear receptor subfamily 2, group C, member 2
NUAK2 NUAK family, SNF1-like kinase, 2
NXPH4 neurexophilin 4
OCA2 oculocutaneous albinism II
OMA1 OMA1 zinc metallopeptidase
OSBPL8 oxysterol binding protein-like 8
OSMR oncostatin M receptor
OSTM1 osteopetrosis associated transmembrane protein 1
PANK1 pantothenate kinase 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PEX11A peroxisomal biogenesis factor 11 alpha
PHYH phytanoyl-CoA 2-hydroxylase
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PITPNA phosphatidylinositol transfer protein, alpha
PITX3 paired-like homeodomain 3
PLA2G12B phospholipase A2, group XIIB
PLAGL2 pleiomorphic adenoma gene-like 2
PLIN2 perilipin 2
PLSCR3 phospholipid scramblase 3
PLVAP plasmalemma vesicle associated protein
PNPLA2 patatin-like phospholipase domain containing 2
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PPP1R3B protein phosphatase 1, regulatory subunit 3B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRF1 perforin 1 (pore forming protein)
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKCI protein kinase C, iota
PRLH prolactin releasing hormone
PTRF polymerase I and transcript release factor
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RNF10 ring finger protein 10
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RSBN1 round spermatid basic protein 1
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCP2 sterol carrier protein 2
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SGMS2 sphingomyelin synthase 2
SGOL2 shugoshin-like 2 (S. pombe)
SIK3 SIK family kinase 3
SIRT3 sirtuin 3
SIRT7 sirtuin 7
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC38A10 solute carrier family 38, member 10
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC51A solute carrier family 51, alpha subunit
SLC5A10 solute carrier family 5 (sodium/sugar cotransporter), member 10
SOAT2 sterol O-acyltransferase 2
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPP1 secreted phosphoprotein 1
SREBF1 sterol regulatory element binding transcription factor 1
STARD10 StAR-related lipid transfer (START) domain containing 10
STEAP4 STEAP family member 4
THRB thyroid hormone receptor, beta
TLR5 toll-like receptor 5
TMEM167A transmembrane protein 167A
TNF tumor necrosis factor
TRA2B transformer 2 beta homolog (Drosophila)
TRPC2 transient receptor potential cation channel, subfamily C, member 2, pseudogene
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TUB tubby bipartite transcription factor
TXNIP thioredoxin interacting protein
UBE2B ubiquitin-conjugating enzyme E2B
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UMOD uromodulin
USH1C Usher syndrome 1C (autosomal recessive, severe)
USHBP1 Usher syndrome 1C binding protein 1
VLDLR very low density lipoprotein receptor
WRN Werner syndrome, RecQ helicase-like
WWOX WW domain containing oxidoreductase
ZEB1 zinc finger E-box binding homeobox 1