abnormal circulating interleukin-18 level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity (Mammalian Phenotype Ontology, MP_0008634)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008634
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Genes

13 gene mutations causing the abnormal circulating interleukin-18 level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AIM2 absent in melanoma 2
CASP12 caspase 12 (gene/pseudogene)
CASP4 caspase 4, apoptosis-related cysteine peptidase
CTSE cathepsin E
F2RL1 coagulation factor II (thrombin) receptor-like 1
GBP5 guanylate binding protein 5
IL18 interleukin 18
IL1R1 interleukin 1 receptor, type I
KRT1 keratin 1, type II
NLRP3 NLR family, pyrin domain containing 3
NLRP6 NLR family, pyrin domain containing 6
PRF1 perforin 1 (pore forming protein)
PYCARD PYD and CARD domain containing