abnormal circulating interleukin-12 level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells (Mammalian Phenotype Ontology, MP_0008616)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008616
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Genes

26 gene mutations causing the abnormal circulating interleukin-12 level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
FLT3 fms-related tyrosine kinase 3
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNGR1 interferon gamma receptor 1
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL12A interleukin 12A
IL12RB2 interleukin 12 receptor, beta 2
IL22 interleukin 22
IL27RA interleukin 27 receptor, alpha
IL6 interleukin 6
ITGAD integrin, alpha D
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LYN LYN proto-oncogene, Src family tyrosine kinase
NPY1R neuropeptide Y receptor Y1
OLFM4 olfactomedin 4
PCSK1 proprotein convertase subtilisin/kexin type 1
PILRB paired immunoglobin-like type 2 receptor beta
SIRT3 sirtuin 3
STAT4 signal transducer and activator of transcription 4
TLR8 toll-like receptor 8
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TYK2 tyrosine kinase 2