abnormal cell cycle checkpoint function Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable (Mammalian Phenotype Ontology, MP_0004045)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004045
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45 gene mutations causing the abnormal cell cycle checkpoint function phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ATM ATM serine/threonine kinase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BUB3 BUB3 mitotic checkpoint protein
CACYBP calcyclin binding protein
CDC25A cell division cycle 25A
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDX2 caudal type homeobox 2
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CUL4A cullin 4A
FANCC Fanconi anemia, complementation group C
GABPA GA binding protein transcription factor, alpha subunit 60kDa
HMGN1 high mobility group nucleosome binding domain 1
HUS1 HUS1 checkpoint homolog (S. pombe)
IFT122 intraflagellar transport 122
LMNA lamin A/C
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MBD4 methyl-CpG binding domain protein 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NBN nibrin
PARP1 poly (ADP-ribose) polymerase 1
PARP2 poly (ADP-ribose) polymerase 2
PLK3 polo-like kinase 3
PPP5C protein phosphatase 5, catalytic subunit
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTTG1 pituitary tumor-transforming 1
RAE1 ribonucleic acid export 1
RB1 retinoblastoma 1
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
SETD7 SET domain containing (lysine methyltransferase) 7
SIN3B SIN3 transcription regulator family member B
SIRT1 sirtuin 1
SMC1A structural maintenance of chromosomes 1A
SYF2 SYF2 pre-mRNA-splicing factor
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP53BP2 tumor protein p53 binding protein 2
TPX2 TPX2, microtubule-associated
TSPYL2 TSPY-like 2
UIMC1 ubiquitin interaction motif containing 1