abnormal cardiac epithelial to mesenchymal transition Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the process by which endocardial cells of the atrioventricular canal or the outflow tract lose their epithelial characteristics, delaminate from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventually forming both the endocardial cushions required for septum and atrioventricular valve formation and the cushions of the outflow tract that form the conotruncal septum (Mammalian Phenotype Ontology, MP_0008825)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008825
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Genes

15 gene mutations causing the abnormal cardiac epithelial to mesenchymal transition phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
EFNA1 ephrin-A1
EPHA3 EPH receptor A3
ERBB3 erb-b2 receptor tyrosine kinase 3
HAS2 hyaluronan synthase 2
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HHEX hematopoietically expressed homeobox
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYL7 myosin, light chain 7, regulatory
NOTCH1 notch 1
POFUT1 protein O-fucosyltransferase 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SMAD6 SMAD family member 6
SSR1 signal sequence receptor, alpha
ZFPM2 zinc finger protein, FOG family member 2