abnormal bone trabecula morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force (Mammalian Phenotype Ontology, MP_0010867)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0010867
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Genes

85 gene mutations causing the abnormal bone trabecula morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABHD5 abhydrolase domain containing 5
ADIPOQ adiponectin, C1Q and collagen domain containing
AGER advanced glycosylation end product-specific receptor
AGTR2 angiotensin II receptor, type 2
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)
APOE apolipoprotein E
ATF4 activating transcription factor 4
CAV1 caveolin 1, caveolae protein, 22kDa
CCR2 chemokine (C-C motif) receptor 2
CD68 CD68 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHSY1 chondroitin sulfate synthase 1
CLCN7 chloride channel, voltage-sensitive 7
CLDN18 claudin 18
CLEC2D C-type lectin domain family 2, member D
CNOT3 CCR4-NOT transcription complex, subunit 3
COL1A2 collagen, type I, alpha 2
COL2A1 collagen, type II, alpha 1
CSF1 colony stimulating factor 1 (macrophage)
CTHRC1 collagen triple helix repeat containing 1
CTSK cathepsin K
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
EIF4E3 eukaryotic translation initiation factor 4E family member 3
FAM20C family with sequence similarity 20, member C
FAM73B family with sequence similarity 73, member B
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBLIM1 filamin binding LIM protein 1
FBN1 fibrillin 1
FIG4 FIG4 phosphoinositide 5-phosphatase
FOS FBJ murine osteosarcoma viral oncogene homolog
FZD9 frizzled class receptor 9
GALC galactosylceramidase
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA1 GATA binding protein 1 (globin transcription factor 1)
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
IGF2 insulin-like growth factor 2
IL10 interleukin 10
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
JAK1 Janus kinase 1
JDP2 Jun dimerization protein 2
KL klotho
KLF10 Kruppel-like factor 10
LMNA lamin A/C
LRP5 low density lipoprotein receptor-related protein 5
LRRK1 leucine-rich repeat kinase 1
MCPH1 microcephalin 1
MGP matrix Gla protein
MIA3 melanoma inhibitory activity family, member 3
NACA nascent polypeptide-associated complex alpha subunit
NBR1 neighbor of BRCA1 gene 1
NCOR2 nuclear receptor corepressor 2
NLRP3 NLR family, pyrin domain containing 3
NOV nephroblastoma overexpressed
NPR2 natriuretic peptide receptor 2
NPR3 natriuretic peptide receptor 3
PDIA3 protein disulfide isomerase family A, member 3
PHF20 PHD finger protein 20
PHOSPHO1 phosphatase, orphan 1
PTHLH parathyroid hormone-like hormone
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPRE protein tyrosine phosphatase, receptor type, E
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
ROR2 receptor tyrosine kinase-like orphan receptor 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
SBNO2 strawberry notch homolog 2 (Drosophila)
SH3BP2 SH3-domain binding protein 2
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
SOST sclerostin
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SUCO SUN domain containing ossification factor
TMEM119 transmembrane protein 119
TMEM64 transmembrane protein 64
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TWSG1 twisted gastrulation BMP signaling modulator 1
TYROBP TYRO protein tyrosine kinase binding protein
WWOX WW domain containing oxidoreductase
XYLT1 xylosyltransferase I