abnormal apical ectodermal ridge morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme (Mammalian Phenotype Ontology, MP_0001676)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001676
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Genes

21 gene mutations causing the abnormal apical ectodermal ridge morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BMP7 bone morphogenetic protein 7
CHUK conserved helix-loop-helix ubiquitous kinase
DKK1 dickkopf WNT signaling pathway inhibitor 1
EN1 engrailed homeobox 1
FGFR2 fibroblast growth factor receptor 2
FUZ fuzzy planar cell polarity protein
GAS1 growth arrest-specific 1
GLI3 GLI family zinc finger 3
GPR161 G protein-coupled receptor 161
GREM1 gremlin 1, DAN family BMP antagonist
HAND2 heart and neural crest derivatives expressed 2
JAG2 jagged 2
LRP4 low density lipoprotein receptor-related protein 4
LRP6 low density lipoprotein receptor-related protein 6
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RSPO2 R-spondin 2
SFN stratifin
SP8 Sp8 transcription factor
TBX3 T-box 3
TP63 tumor protein p63