abnormal anxiety-related response Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description altered emotional response related to anticipation of a non-specific threat (Mammalian Phenotype Ontology, MP_0001362)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001362
Similar Terms
Downloads & Tools

Genes

224 gene mutations causing the abnormal anxiety-related response phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADCY8 adenylate cyclase 8 (brain)
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADGRL3 adhesion G protein-coupled receptor L3
ADORA1 adenosine A1 receptor
ADORA2A adenosine A2a receptor
AKAP5 A kinase (PRKA) anchor protein 5
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ARX aristaless related homeobox
ASPA aspartoacylase
ATAT1 alpha tubulin acetyltransferase 1
ATF7 activating transcription factor 7
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
AVPR1A arginine vasopressin receptor 1A
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BACE1 beta-site APP-cleaving enzyme 1
BBS4 Bardet-Biedl syndrome 4
BDNF brain-derived neurotrophic factor
C12ORF10 chromosome 12 open reading frame 10
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CADPS2 Ca++-dependent secretion activator 2
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCKBR cholecystokinin B receptor
CDKL5 cyclin-dependent kinase-like 5
CER1 cerberus 1, DAN family BMP antagonist
CERS1 ceramide synthase 1
CHD6 chromodomain helicase DNA binding protein 6
CHL1 cell adhesion molecule L1-like
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CLCN6 chloride channel, voltage-sensitive 6
CNIH1 cornichon family AMPA receptor auxiliary protein 1
CNR1 cannabinoid receptor 1 (brain)
COMT catechol-O-methyltransferase
CPEB3 cytoplasmic polyadenylation element binding protein 3
CPLX2 complexin 2
CREM cAMP responsive element modulator
CRHBP corticotropin releasing hormone binding protein
CRHR1 corticotropin releasing hormone receptor 1
CRHR2 corticotropin releasing hormone receptor 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSK c-src tyrosine kinase
CSMD1 CUB and Sushi multiple domains 1
CTNS cystinosin, lysosomal cystine transporter
DCDC2 doublecortin domain containing 2
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DISC1 disrupted in schizophrenia 1
DLG4 discs, large homolog 4 (Drosophila)
DLGAP3 discs, large (Drosophila) homolog-associated protein 3
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DUSP1 dual specificity phosphatase 1
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1
EMC10 ER membrane protein complex subunit 10
EPM2AIP1 EPM2A (laforin) interacting protein 1
ESR2 estrogen receptor 2 (ER beta)
FABP7 fatty acid binding protein 7, brain
FAM3D family with sequence similarity 3, member D
FEV FEV (ETS oncogene family)
FGFBP3 fibroblast growth factor binding protein 3
FKBP5 FK506 binding protein 5
FMR1 fragile X mental retardation 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FSHR follicle stimulating hormone receptor
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GBX1 gastrulation brain homeobox 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GJB6 gap junction protein, beta 6, 30kDa
GPR19 G protein-coupled receptor 19
GPR26 G protein-coupled receptor 26
GPR83 G protein-coupled receptor 83
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
GRM2 glutamate receptor, metabotropic 2
GRM3 glutamate receptor, metabotropic 3
GRM8 glutamate receptor, metabotropic 8
GRN granulin
GTF2I general transcription factor IIi
GTF2IRD1 GTF2I repeat domain containing 1
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1
HDC histidine decarboxylase
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRH3 histamine receptor H3
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IDS iduronate 2-sulfatase
IDUA iduronidase, alpha-L-
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IL1R1 interleukin 1 receptor, type I
IL6 interleukin 6
INS insulin
KALRN kalirin, RhoGEF kinase
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5
KCNIP3 Kv channel interacting protein 3, calsenilin
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KIF13A kinesin family member 13A
L1CAM L1 cell adhesion molecule
LPAR5 lysophosphatidic acid receptor 5
LRP5 low density lipoprotein receptor-related protein 5
LRRC7 leucine rich repeat containing 7
LRRN1 leucine rich repeat neuronal 1
LRRTM1 leucine rich repeat transmembrane neuronal 1
LSAMP limbic system-associated membrane protein
LYPD1 LY6/PLAUR domain containing 1
MAP6 microtubule-associated protein 6
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MAPT microtubule-associated protein tau
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MCHR1 melanin-concentrating hormone receptor 1
MDK midkine (neurite growth-promoting factor 2)
MECP2 methyl CpG binding protein 2
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MPST mercaptopyruvate sulfurtransferase
MYO7A myosin VIIA
NAGLU N-acetylglucosaminidase, alpha
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
NENF neudesin neurotrophic factor
NLGN3 neuroligin 3
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPAS3 neuronal PAS domain protein 3
NPAS4 neuronal PAS domain protein 4
NPEPPS aminopeptidase puromycin sensitive
NPY neuropeptide Y
NPY2R neuropeptide Y receptor Y2
NTAN1 N-terminal asparagine amidase
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OPHN1 oligophrenin 1
OPRD1 opioid receptor, delta 1
OXT oxytocin/neurophysin I prepropeptide
PARK2 parkin RBR E3 ubiquitin protein ligase
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDYN prodynorphin
PENK proenkephalin
PITX3 paired-like homeodomain 3
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRKCG protein kinase C, gamma
PRKCZ protein kinase C, zeta
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PSAP prosaposin
PTPRA protein tyrosine phosphatase, receptor type, A
RAI1 retinoic acid induced 1
RASD2 RASD family, member 2
RGS2 regulator of G-protein signaling 2
RIC8A RIC8 guanine nucleotide exchange factor A
RLN3 relaxin 3
RNF103 ring finger protein 103
S100A1 S100 calcium binding protein A1
S100A10 S100 calcium binding protein A10
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SEPT5 septin 5
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SHANK1 SH3 and multiple ankyrin repeat domains 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SHANK3 SH3 and multiple ankyrin repeat domains 3
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLITRK1 SLIT and NTRK-like family, member 1
SLITRK5 SLIT and NTRK-like family, member 5
SNAP25 synaptosomal-associated protein, 25kDa
SPPL3 signal peptide peptidase like 3
SPRED1 sprouty-related, EVH1 domain containing 1
SRR serine racemase
SSTR2 somatostatin receptor 2
STX1A syntaxin 1A (brain)
SV2C synaptic vesicle glycoprotein 2C
SYNGAP1 synaptic Ras GTPase activating protein 1
SYNPO synaptopodin
TAC1 tachykinin, precursor 1
TACR1 tachykinin receptor 1
TBX1 T-box 1
TDO2 tryptophan 2,3-dioxygenase
THRA thyroid hormone receptor, alpha
TLR3 toll-like receptor 3
TMEM43 transmembrane protein 43
TNC tenascin C
TNF tumor necrosis factor
TPH2 tryptophan hydroxylase 2
TRHR thyrotropin-releasing hormone receptor
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBA1A tubulin, alpha 1a
UCN urocortin
ULK2 unc-51 like autophagy activating kinase 2
USP46 ubiquitin specific peptidase 46
VAMP7 vesicle-associated membrane protein 7
VIM vimentin
WASF1 WAS protein family, member 1
WFS1 Wolfram syndrome 1 (wolframin)