Y-27632-948 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the Y-27632-948 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACVR1B activin A receptor, type IB
ALPK1 alpha-kinase 1
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ART1 ADP-ribosyltransferase 1
ATG4B autophagy related 4B, cysteine peptidase
BAX BCL2-associated X protein
C7ORF43 chromosome 7 open reading frame 43
CDC25A cell division cycle 25A
CDK13 cyclin-dependent kinase 13
CEP162 centrosomal protein 162kDa
CLIP4 CAP-GLY domain containing linker protein family, member 4
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
CRTC1 CREB regulated transcription coactivator 1
CRY2 cryptochrome circadian clock 2
CRYBG3 beta-gamma crystallin domain containing 3
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTNNBIP1 catenin, beta interacting protein 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DIEXF digestive organ expansion factor homolog (zebrafish)
DMTN dematin actin binding protein
DTNA dystrobrevin, alpha
EML2 echinoderm microtubule associated protein like 2
EPHB2 EPH receptor B2
EXOC7 exocyst complex component 7
FBXL15 F-box and leucine-rich repeat protein 15
FER fer (fps/fes related) tyrosine kinase
FGD1 FYVE, RhoGEF and PH domain containing 1
FURIN furin (paired basic amino acid cleaving enzyme)
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAS7 growth arrest-specific 7
GK3P glycerol kinase 3 pseudogene
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPRC5D G protein-coupled receptor, class C, group 5, member D
GSTM4 glutathione S-transferase mu 4
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
GYG2 glycogenin 2
HEG1 heart development protein with EGF-like domains 1
HLA-G major histocompatibility complex, class I, G
HOXA2 homeobox A2
IFT122 intraflagellar transport 122
JMJD4 jumonji domain containing 4
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LDB1 LIM domain binding 1
LMAN1 lectin, mannose-binding, 1
LRP5L low density lipoprotein receptor-related protein 5-like
MAGOH2P mago-nashi homolog 2, pseudogene
MBD1 methyl-CpG binding domain protein 1
MCC mutated in colorectal cancers
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MSL3 male-specific lethal 3 homolog (Drosophila)
MYL5 myosin, light chain 5, regulatory
NCOR2 nuclear receptor corepressor 2
NEB nebulin
NEK11 NIMA-related kinase 11
NF1 neurofibromin 1
NPTX1 neuronal pentraxin I
NRG1 neuregulin 1
NT5DC3 5'-nucleotidase domain containing 3
PAPOLA poly(A) polymerase alpha
PCNX pecanex homolog (Drosophila)
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PEX5 peroxisomal biogenesis factor 5
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PSG9 pregnancy specific beta-1-glycoprotein 9
QKI QKI, KH domain containing, RNA binding
RAB27B RAB27B, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RGS10 regulator of G-protein signaling 10
RHOQ ras homolog family member Q
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RPS28 ribosomal protein S28
SCAF4 SR-related CTD-associated factor 4
SCARB1 scavenger receptor class B, member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFTPB surfactant protein B
SHARPIN SHANK-associated RH domain interactor
SYMPK symplekin
TEAD3 TEA domain family member 3
TERT telomerase reverse transcriptase
TGFB2 transforming growth factor, beta 2
THAP9 THAP domain containing 9
TRA2A transformer 2 alpha homolog (Drosophila)
USP27X ubiquitin specific peptidase 27, X-linked
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
ZNF224 zinc finger protein 224
ZNF329 zinc finger protein 329

decreased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ABLIM3 actin binding LIM protein family, member 3
ACVR2A activin A receptor, type IIA
AES amino-terminal enhancer of split
AKAP12 A kinase (PRKA) anchor protein 12
ANKRD36 ankyrin repeat domain 36
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARMC6 armadillo repeat containing 6
ARRB1 arrestin, beta 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCL9 B-cell CLL/lymphoma 9
C16ORF45 chromosome 16 open reading frame 45
C1ORF115 chromosome 1 open reading frame 115
C5ORF45 chromosome 5 open reading frame 45
CA11 carbonic anhydrase XI
CASD1 CAS1 domain containing 1
CLSPN claspin
CNPY3 canopy FGF signaling regulator 3
CTC1 CTS telomere maintenance complex component 1
DEPTOR DEP domain containing MTOR-interacting protein
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DGKD diacylglycerol kinase, delta 130kDa
DHRS11 dehydrogenase/reductase (SDR family) member 11
DMXL1 Dmx-like 1
DNAAF2 dynein, axonemal, assembly factor 2
DUSP8 dual specificity phosphatase 8
DZANK1 double zinc ribbon and ankyrin repeat domains 1
ECSIT ECSIT signalling integrator
EHD3 EH-domain containing 3
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
F8 coagulation factor VIII, procoagulant component
GAREM GRB2 associated, regulator of MAPK1
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
HMG20A high mobility group 20A
HS1BP3 HCLS1 binding protein 3
IRF2 interferon regulatory factor 2
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KLC2 kinesin light chain 2
KRT86 keratin 86, type II
MANSC1 MANSC domain containing 1
MAP7D3 MAP7 domain containing 3
MBOAT2 membrane bound O-acyltransferase domain containing 2
MDM4 MDM4, p53 regulator
METTL2B methyltransferase like 2B
METTL8 methyltransferase like 8
MEX3C mex-3 RNA binding family member C
MOSPD3 motile sperm domain containing 3
MTA2 metastasis associated 1 family, member 2
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NCAM2 neural cell adhesion molecule 2
NPY1R neuropeptide Y receptor Y1
NR2C2 nuclear receptor subfamily 2, group C, member 2
NRGN neurogranin (protein kinase C substrate, RC3)
NUBPL nucleotide binding protein-like
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
OSMR oncostatin M receptor
PARD6A par-6 family cell polarity regulator alpha
PERP PERP, TP53 apoptosis effector
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
PYCRL pyrroline-5-carboxylate reductase-like
REPS2 RALBP1 associated Eps domain containing 2
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RPH3AL rabphilin 3A-like (without C2 domains)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRAGB Ras-related GTP binding B
RWDD3 RWD domain containing 3
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SIDT1 SID1 transmembrane family, member 1
SLC46A3 solute carrier family 46, member 3
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SMAD7 SMAD family member 7
SNHG3 small nucleolar RNA host gene 3
SNX16 sorting nexin 16
SP140L SP140 nuclear body protein-like
SYNGR3 synaptogyrin 3
TMEM110 transmembrane protein 110
TMEM62 transmembrane protein 62
TMUB2 transmembrane and ubiquitin-like domain containing 2
TTLL1 tubulin tyrosine ligase-like family member 1
TUBA3C tubulin, alpha 3c
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UROS uroporphyrinogen III synthase
WDR91 WD repeat domain 91
YBX2 Y box binding protein 2
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF324 zinc finger protein 324
ZNF365 zinc finger protein 365
ZNF432 zinc finger protein 432
ZNF510 zinc finger protein 510
ZNF552 zinc finger protein 552
ZNF574 zinc finger protein 574
ZNF623 zinc finger protein 623
ZNF665 zinc finger protein 665
ZNF778 zinc finger protein 778
ZNHIT2 zinc finger, HIT-type containing 2