Weight Loss Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Reduction inexisting body weight. (Human Phenotype Ontology, HP_0001824)
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Genes

152 genes associated with the Weight Loss phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
ACE angiotensin I converting enzyme
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADCY5 adenylate cyclase 5
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRA2A adrenoceptor alpha 2A
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANKK1 ankyrin repeat and kinase domain containing 1
APOA5 apolipoprotein A-V
APOC3 apolipoprotein C-III
APOE apolipoprotein E
AR androgen receptor
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGAP35 Rho GTPase activating protein 35
ATXN3 ataxin 3
AVPR2 arginine vasopressin receptor 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL2A1 BCL2-related protein A1
BDKRB2 bradykinin receptor B2
BDNF brain-derived neurotrophic factor
CCK cholecystokinin
CDC123 cell division cycle 123
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CES1 carboxylesterase 1
CETP cholesteryl ester transfer protein, plasma
CHCHD2P9 coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9
CLOCK clock circadian regulator
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
CNTF ciliary neurotrophic factor
COMT catechol-O-methyltransferase
CRP C-reactive protein, pentraxin-related
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DGKB diacylglycerol kinase, beta 90kDa
DRD2 dopamine receptor D2
DRD4 dopamine receptor D4
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESR1 estrogen receptor 1
ETV5 ets variant 5
FAAH fatty acid amide hydrolase
FABP1 fatty acid binding protein 1, liver
FABP2 fatty acid binding protein 2, intestinal
FAIM2 Fas apoptotic inhibitory molecule 2
FTO fat mass and obesity associated
GCK glucokinase (hexokinase 4)
GCKR glucokinase (hexokinase 4) regulator
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GIPR gastric inhibitory polypeptide receptor
GNAS GNAS complex locus
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNPDA2 glucosamine-6-phosphate deaminase 2
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
HHEX hematopoietically expressed homeobox
HMGA2 high mobility group AT-hook 2
HNF1A HNF1 homeobox A
HNF1B HNF1 homeobox B
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IGF1R insulin-like growth factor 1 receptor
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL10 interleukin 10
IL18 interleukin 18
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
INSIG2 insulin induced gene 2
IRS1 insulin receptor substrate 1
JAZF1 JAZF zinc finger 1
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCTD15 potassium channel tetramerization domain containing 15
LEP leptin
LEPR leptin receptor
LIPC lipase, hepatic
LPA lipoprotein, Lp(a)
LPIN1 lipin 1
LPL lipoprotein lipase
LYPLAL1 lysophospholipase-like 1
MC3R melanocortin 3 receptor
MC4R melanocortin 4 receptor
MLXIPL MLX interacting protein-like
MSRA methionine sulfoxide reductase A
MTCH2 mitochondrial carrier 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTNR1B melatonin receptor 1B
NAMPT nicotinamide phosphoribosyltransferase
NEGR1 neuronal growth regulator 1
NMB neuromedin B
NMBR neuromedin B receptor
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH2 notch 2
NPY neuropeptide Y
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OPRM1 opioid receptor, mu 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK1 proprotein convertase subtilisin/kexin type 1
PER2 period circadian clock 2
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PLA2G2D phospholipase A2, group IID
PLAUR plasminogen activator, urokinase receptor
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLIN1 perilipin 1
PNMT phenylethanolamine N-methyltransferase
PNPLA3 patatin-like phospholipase domain containing 3
POMC proopiomelanocortin
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PROX1 prospero homeobox 1
PYY peptide YY
RETN resistin
SCAP SREBF chaperone
SEC16B SEC16 homolog B (S. cerevisiae)
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH2B1 SH2B adaptor protein 1
SIRT1 sirtuin 1
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLCO3A1 solute carrier organic anion transporter family, member 3A1
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THADA thyroid adenoma associated
TMEM18 transmembrane protein 18
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TSGA13 testis specific, 13
TSPAN8 tetraspanin 8
TUB tubby bipartite transcription factor
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
VPS33B vacuolar protein sorting 33 homolog B (yeast)
WFS1 Wolfram syndrome 1 (wolframin)
ZBED3 zinc finger, BED-type containing 3