Weight Gain Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

257 genes associated with the Weight Gain phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ACE angiotensin I converting enzyme
ACHE acetylcholinesterase (Yt blood group)
ACLY ATP citrate lyase
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADCY1 adenylate cyclase 1 (brain)
ADCY2 adenylate cyclase 2 (brain)
ADCY8 adenylate cyclase 8 (brain)
ADCY9 adenylate cyclase 9
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADORA2A adenosine A2a receptor
ADRA1A adrenoceptor alpha 1A
ADRA2A adrenoceptor alpha 2A
ADRA2B adrenoceptor alpha 2B
ADRA2C adrenoceptor alpha 2C
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGRP agouti related neuropeptide
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANGPTL4 angiopoietin-like 4
ANKK1 ankyrin repeat and kinase domain containing 1
APOE apolipoprotein E
AR androgen receptor
BCHE butyrylcholinesterase
BDNF brain-derived neurotrophic factor
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CACNG2 calcium channel, voltage-dependent, gamma subunit 2
CADM2 cell adhesion molecule 2
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CARTPT CART prepropeptide
CCK cholecystokinin
CCKAR cholecystokinin A receptor
CCKBR cholecystokinin B receptor
CCL2 chemokine (C-C motif) ligand 2
CDC123 cell division cycle 123
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CHAT choline O-acetyltransferase
CHRM1 cholinergic receptor, muscarinic 1
CHRM2 cholinergic receptor, muscarinic 2
CHRM3 cholinergic receptor, muscarinic 3
CHRM4 cholinergic receptor, muscarinic 4
CHRM5 cholinergic receptor, muscarinic 5
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CLOCK clock circadian regulator
CNR1 cannabinoid receptor 1 (brain)
CNTF ciliary neurotrophic factor
COMT catechol-O-methyltransferase
COX18 COX18 cytochrome c oxidase assembly factor
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CRP C-reactive protein, pentraxin-related
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DAO D-amino-acid oxidase
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DRD5 dopamine receptor D5
ESR1 estrogen receptor 1
ETV5 ets variant 5
FAAH fatty acid amide hydrolase
FABP1 fatty acid binding protein 1, liver
FABP3 fatty acid binding protein 3, muscle and heart
FAIM2 Fas apoptotic inhibitory molecule 2
FASN fatty acid synthase
FTO fat mass and obesity associated
G6PC2 glucose-6-phosphatase, catalytic, 2
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GHRL ghrelin/obestatin prepropeptide
GLS glutaminase
GLUD1 glutamate dehydrogenase 1
GLUD2 glutamate dehydrogenase 2
GLUL glutamate-ammonia ligase
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNPDA2 glucosamine-6-phosphate deaminase 2
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRIK3 glutamate receptor, ionotropic, kainate 3
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
GRM1 glutamate receptor, metabotropic 1
GRM2 glutamate receptor, metabotropic 2
GRM3 glutamate receptor, metabotropic 3
GRM4 glutamate receptor, metabotropic 4
GRM5 glutamate receptor, metabotropic 5
GRM6 glutamate receptor, metabotropic 6
GRM7 glutamate receptor, metabotropic 7
GRM8 glutamate receptor, metabotropic 8
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HDC histidine decarboxylase
HHEX hematopoietically expressed homeobox
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HNMT histamine N-methyltransferase
HRH1 histamine receptor H1
HRH2 histamine receptor H2
HRH3 histamine receptor H3
HRH4 histamine receptor H4
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
HTRA1 HtrA serine peptidase 1
IDE insulin-degrading enzyme
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL6 interleukin 6
IL6R interleukin 6 receptor
INS insulin
INSIG1 insulin induced gene 1
INSIG2 insulin induced gene 2
JAZF1 JAZF zinc finger 1
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KCTD15 potassium channel tetramerization domain containing 15
LEP leptin
LEPR leptin receptor
LIPF lipase, gastric
LMOD1 leiomodin 1 (smooth muscle)
LMOD3 leiomodin 3 (fetal)
LPIN1 lipin 1
LPL lipoprotein lipase
LYPLAL1 lysophospholipase-like 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MC4R melanocortin 4 receptor
MLXIPL MLX interacting protein-like
MSRA methionine sulfoxide reductase A
MTCH2 mitochondrial carrier 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
NEGR1 neuronal growth regulator 1
NOTCH2 notch 2
NOTCH4 notch 4
NPC1 Niemann-Pick disease, type C1
NPY neuropeptide Y
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRXN3 neurexin 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLAUR plasminogen activator, urokinase receptor
PLIN1 perilipin 1
PMCH pro-melanin-concentrating hormone
PNPLA3 patatin-like phospholipase domain containing 3
POC5 POC5 centriolar protein
POMC proopiomelanocortin
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PPP3R2 protein phosphatase 3, regulatory subunit B, beta
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit
PRKD1 protein kinase D1
PRNP prion protein
PTER phosphotriesterase related
PYY peptide YY
RELN reelin
RGS9 regulator of G-protein signaling 9
RIMS1 regulating synaptic membrane exocytosis 1
SCAP SREBF chaperone
SDCCAG8 serologically defined colon cancer antigen 8
SEC16B SEC16 homolog B (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH2B1 SH2B adaptor protein 1
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SNAP25 synaptosomal-associated protein, 25kDa
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
SULT4A1 sulfotransferase family 4A, member 1
SYT11 synaptotagmin XI
SYT4 synaptotagmin IV
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TCF20 transcription factor 20 (AR1)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TH tyrosine hydroxylase
THADA thyroid adenoma associated
TMEM18 transmembrane protein 18
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TNNI3 troponin I type 3 (cardiac)
TPH1 tryptophan hydroxylase 1
TPH2 tryptophan hydroxylase 2
TSPAN8 tetraspanin 8
TUB tubby bipartite transcription factor
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WFS1 Wolfram syndrome 1 (wolframin)
ZADH2 zinc binding alcohol dehydrogenase domain containing 2
ZDHHC8 zinc finger, DHHC-type containing 8