Vitiligo Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A hypersensitivity reaction type II disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes. (Human Disease Ontology, DOID_12306)
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Genes

106 genes associated with the Vitiligo phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
AHR aryl hydrocarbon receptor
AIRE autoimmune regulator
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
C12ORF10 chromosome 12 open reading frame 10
C1QTNF6 C1q and tumor necrosis factor related protein 6
C4A complement component 4A (Rodgers blood group)
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAT catalase
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CD4 CD4 molecule
CD44 CD44 molecule (Indian blood group)
CD80 CD80 molecule
CDK5RAP1 CDK5 regulatory subunit associated protein 1
CLEC11A C-type lectin domain family 11, member A
CLNK cytokine-dependent hematopoietic cell linker
COMT catechol-O-methyltransferase
CORO2A coronin, actin binding protein, 2A
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CTLA4 cytotoxic T-lymphocyte-associated protein 4
DDR1 discoidin domain receptor tyrosine kinase 1
DNAH5 dynein, axonemal, heavy chain 5
EDN1 endothelin 1
ESR1 estrogen receptor 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBXO11 F-box protein 11
FGFR1OP FGFR1 oncogene partner
FOXD3 forkhead box D3
FOXO3 forkhead box O3
FOXP1 forkhead box P1
FOXP3 forkhead box P3
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
ICA1 islet cell autoantigen 1, 69kDa
IFIH1 interferon induced with helicase C domain 1
IFNE interferon, epsilon
IFNG interferon, gamma
IKZF4 IKAROS family zinc finger 4 (Eos)
IL10 interleukin 10
IL1RN interleukin 1 receptor antagonist
IL2RA interleukin 2 receptor, alpha
IL4 interleukin 4
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
LPP LIM domain containing preferred translocation partner in lipoma
LTA lymphotoxin alpha
MBL2 mannose-binding lectin (protein C) 2, soluble
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MIR196A1 microRNA 196a-1
MPO myeloperoxidase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NFE2L2 nuclear factor, erythroid 2-like 2
NLRP1 NLR family, pyrin domain containing 1
NOS2 nitric oxide synthase 2, inducible
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
OCA2 oculocutaneous albinism II
PARP1 poly (ADP-ribose) polymerase 1
PDE10A phosphodiesterase 10A
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RAB5B RAB5B, member RAS oncogene family
RERE arginine-glutamic acid dipeptide (RE) repeats
RNASET2 ribonuclease T2
RPGRIP1L RPGRIP1-like
SH2B3 SH2B adaptor protein 3
SLA Src-like-adaptor
SLC44A4 solute carrier family 44, member 4
SMOC2 SPARC related modular calcium binding 2
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
STAT4 signal transducer and activator of transcription 4
STRN3 striatin, calmodulin binding protein 3
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TOB2 transducer of ERBB2, 2
TSLP thymic stromal lymphopoietin
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum)
TYR tyrosinase
UBASH3A ubiquitin associated and SH3 domain containing A
UVRAG UV radiation resistance associated
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
XBP1 X-box binding protein 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1