Ursodeoxycholic Acid Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones. (Chemical Entities of Biological Interest Ontology, CHEBI_9907)
External Link http://ctdbase.org/detail.go?type=chem&acc=D014580
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Genes

87 genes/proteins interacting with the chemical Ursodeoxycholic Acid from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AKT1 v-akt murine thymoma viral oncogene homolog 1
APAF1 apoptotic peptidase activating factor 1
APOM apolipoprotein M
ARNT aryl hydrocarbon receptor nuclear translocator
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BLVRA biliverdin reductase A
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCND1 cyclin D1
CCND3 cyclin D3
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFLAR CASP8 and FADD-like apoptosis regulator
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DLC1 DLC1 Rho GTPase activating protein
E2F1 E2F transcription factor 1
EDN1 endothelin 1
EDN2 endothelin 2
EGFR epidermal growth factor receptor
EP300 E1A binding protein p300
GCLC glutamate-cysteine ligase, catalytic subunit
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HNF1A HNF1 homeobox A
HNF1B HNF1 homeobox B
HRAS Harvey rat sarcoma viral oncogene homolog
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IFNG interferon, gamma
IL6 interleukin 6
IVL involucrin
KRAS Kirsten rat sarcoma viral oncogene homolog
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MPO myeloperoxidase
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOS2 nitric oxide synthase 2, inducible
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C2 nuclear receptor subfamily 3, group C, member 2
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PGR progesterone receptor
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRDX1 peroxiredoxin 1
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RB1 retinoblastoma 1
RHOA ras homolog family member A
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
TAT tyrosine aminotransferase
TBXA2R thromboxane A2 receptor
TBXAS1 thromboxane A synthase 1 (platelet)
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53 tumor protein p53