Typhoid Fever Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A primary bacterial infectious disease that is a communicable systemic illness, has_material_basis_in Salmonella enterica subsp enterica serovar Typhi, which is transmitted_by ingestion of food or water contaminated with the feces of an infected person. The infection has_symptom fever, has_symptom diarrhea, has_symptom prostration, has_symptom headache, has_symptom splenomegaly, has_symptom liver enlargement, has_symptom eruption of rose-colored spots, and has_symptom leukopenia. (Human Disease Ontology, DOID_13258)
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Genes

17 genes associated with the Typhoid Fever phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
CASP1 caspase 1, apoptosis-related cysteine peptidase
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CRP C-reactive protein, pentraxin-related
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IL12B interleukin 12B
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
LTA lymphotoxin alpha
PARK2 parkin RBR E3 ubiquitin protein ligase
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A