Type 2 diabetes mellitus_Muscle tissue_GSE12643 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Diseases
Category transcriptomics
Type disease perturbation
Description disease perturbation identified as [disease]_[tissue]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE12643
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Genes

600 genes differentially expressed during Type 2 diabetes mellitus_Muscle tissue_GSE12643 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

increased expression

Symbol Name Standardized Value
KNTC1 kinetochore associated 1 3.53135
ZSCAN12 zinc finger and SCAN domain containing 12 3.22123
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.94178
BRAF B-Raf proto-oncogene, serine/threonine kinase 2.85301
GDE1 glycerophosphodiester phosphodiesterase 1 2.77303
BPI bactericidal/permeability-increasing protein 2.76547
EML1 echinoderm microtubule associated protein like 1 2.62868
IMPG1 interphotoreceptor matrix proteoglycan 1 2.62099
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.59208
ZNF780A zinc finger protein 780A 2.52941
RAD51B RAD51 paralog B 2.5233
R3HCC1L R3H domain and coiled-coil containing 1-like 2.52216
NDRG4 NDRG family member 4 2.48485
CYB5R3 cytochrome b5 reductase 3 2.4735
E2F6 E2F transcription factor 6 2.45235
BTD biotinidase 2.43646
ELF5 E74-like factor 5 (ets domain transcription factor) 2.4083
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 2.40488
DPF2 D4, zinc and double PHD fingers family 2 2.40371
CD81 CD81 molecule 2.38666
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa 2.38419
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.37554
TKTL1 transketolase-like 1 2.35578
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 2.34725
DMP1 dentin matrix acidic phosphoprotein 1 2.33997
TTC30A tetratricopeptide repeat domain 30A 2.31978
TRAFD1 TRAF-type zinc finger domain containing 1 2.31927
N4BP3 NEDD4 binding protein 3 2.31434
ADAM20 ADAM metallopeptidase domain 20 2.3046
ANO3 anoctamin 3 2.30374
TACR1 tachykinin receptor 1 2.30016
SCYL3 SCY1-like 3 (S. cerevisiae) 2.29283
FAM105A family with sequence similarity 105, member A 2.28127
EXT2 exostosin glycosyltransferase 2 2.25864
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase 2.25599
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 2.25327
CNTRL centriolin 2.2517
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) 2.22915
SSX3 synovial sarcoma, X breakpoint 3 2.20629
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 2.20252
CTNNBIP1 catenin, beta interacting protein 1 2.19919
ATXN7L1 ataxin 7-like 1 2.18491
GRIK2 glutamate receptor, ionotropic, kainate 2 2.16717
ARL4D ADP-ribosylation factor-like 4D 2.15446
ALOX15B arachidonate 15-lipoxygenase, type B 2.13495
SV2C synaptic vesicle glycoprotein 2C 2.12095
RNASEH2A ribonuclease H2, subunit A 2.11887
MATN2 matrilin 2 2.11884
PDE12 phosphodiesterase 12 2.11413
ACVR1 activin A receptor, type I 2.1092
RAD51AP1 RAD51 associated protein 1 2.09829
STK16 serine/threonine kinase 16 2.09773
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 2.07041
FER fer (fps/fes related) tyrosine kinase 2.05966
CRISP1 cysteine-rich secretory protein 1 2.04997
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 2.04318
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 2.04177
CXCL13 chemokine (C-X-C motif) ligand 13 2.04076
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD) 2.00514
ZNF75D zinc finger protein 75D 2.00177
RNF216 ring finger protein 216 2.00175
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 1.99682
S100A7 S100 calcium binding protein A7 1.99607
BRAP BRCA1 associated protein 1.99232
CDH12 cadherin 12, type 2 (N-cadherin 2) 1.98807
ARRB2 arrestin, beta 2 1.97935
BMP3 bone morphogenetic protein 3 1.97811
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 1.95137
CRISP2 cysteine-rich secretory protein 2 1.94966
CKM creatine kinase, muscle 1.94768
ACSM3 acyl-CoA synthetase medium-chain family member 3 1.94156
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 1.93996
RBM10 RNA binding motif protein 10 1.93822
T T, brachyury homolog (mouse) 1.93644
BRDT bromodomain, testis-specific 1.93272
CHEK1 checkpoint kinase 1 1.92952
TLE2 transducin-like enhancer of split 2 1.91945
SIK3 SIK family kinase 3 1.91334
ST7 suppression of tumorigenicity 7 1.90146
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.90061
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 1.90037
TXK TXK tyrosine kinase 1.89598
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 1.89472
ZNF143 zinc finger protein 143 1.89026
CDC40 cell division cycle 40 1.88473
AKAP4 A kinase (PRKA) anchor protein 4 1.88402
ZNF81 zinc finger protein 81 1.88202
PTTG2 pituitary tumor-transforming 2 1.87536
PDE3A phosphodiesterase 3A, cGMP-inhibited 1.87043
TPGS2 tubulin polyglutamylase complex subunit 2 1.86559
LINC00563 long intergenic non-protein coding RNA 563 1.86215
ZNF250 zinc finger protein 250 1.85724
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense 1.85684
PIWIL1 piwi-like RNA-mediated gene silencing 1 1.8556
COCH cochlin 1.85351
ZNF202 zinc finger protein 202 1.85131
TRIM9 tripartite motif containing 9 1.84479
IAPP islet amyloid polypeptide 1.84409
MUC4 mucin 4, cell surface associated 1.84236
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 1.83603
ZNF85 zinc finger protein 85 1.83477
GTPBP10 GTP-binding protein 10 (putative) 1.83227
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 1.82965
PDK4 pyruvate dehydrogenase kinase, isozyme 4 1.82596
FGL2 fibrinogen-like 2 1.82498
RAG1 recombination activating gene 1 1.81984
C6ORF10 chromosome 6 open reading frame 10 1.80937
CD38 CD38 molecule 1.80754
KLF4 Kruppel-like factor 4 (gut) 1.79993
CTSW cathepsin W 1.7869
VSNL1 visinin-like 1 1.78589
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 1.78137
IL1RN interleukin 1 receptor antagonist 1.78067
L3MBTL1 l(3)mbt-like 1 (Drosophila) 1.77768
OMG oligodendrocyte myelin glycoprotein 1.77411
PRR4 proline rich 4 (lacrimal) 1.77207
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor 1.77169
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 1.76953
GAB1 GRB2-associated binding protein 1 1.76505
LAMP1 lysosomal-associated membrane protein 1 1.76489
NFE2 nuclear factor, erythroid 2 1.76441
DCT dopachrome tautomerase 1.75668
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa 1.7545
DPH2 DPH2 homolog (S. cerevisiae) 1.75293
LIN7A lin-7 homolog A (C. elegans) 1.75289
PRSS16 protease, serine, 16 (thymus) 1.75001
VAMP3 vesicle-associated membrane protein 3 1.74808
SAA4 serum amyloid A4, constitutive 1.74802
ASF1A anti-silencing function 1A histone chaperone 1.7459
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.73949
WISP1 WNT1 inducible signaling pathway protein 1 1.72904
RORA RAR-related orphan receptor A 1.72759
TRIM23 tripartite motif containing 23 1.72278
KLF11 Kruppel-like factor 11 1.71862
ERP44 endoplasmic reticulum protein 44 1.7163
SOX30 SRY (sex determining region Y)-box 30 1.71221
AGTPBP1 ATP/GTP binding protein 1 1.70239
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 1.699
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 1.6976
CLCA2 chloride channel accessory 2 1.69371
HNF4G hepatocyte nuclear factor 4, gamma 1.69256
CLIC5 chloride intracellular channel 5 1.69142
POU4F2 POU class 4 homeobox 2 1.69002
ANKRD26 ankyrin repeat domain 26 1.68544
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 1.68492
NRG2 neuregulin 2 1.68151
APOA2 apolipoprotein A-II 1.6813
TRAK2 trafficking protein, kinesin binding 2 1.68115
AFM afamin 1.67972
PZP pregnancy-zone protein 1.67872
AP2A2 adaptor-related protein complex 2, alpha 2 subunit 1.67631
ENOX2 ecto-NOX disulfide-thiol exchanger 2 1.67079
ZNF35 zinc finger protein 35 1.66977
ST14 suppression of tumorigenicity 14 (colon carcinoma) 1.6688
CA2 carbonic anhydrase II 1.66384
EAPP E2F-associated phosphoprotein 1.66164
FOLR2 folate receptor 2 (fetal) 1.65885
AP3B2 adaptor-related protein complex 3, beta 2 subunit 1.65789
ZNF137P zinc finger protein 137, pseudogene 1.6553
DKFZP586K1520 DKFZP586K1520 protein 1.65394
OVGP1 oviductal glycoprotein 1, 120kDa 1.65346
IFNA10 interferon, alpha 10 1.65198
SLC30A4 solute carrier family 30 (zinc transporter), member 4 1.64945
C4BPB complement component 4 binding protein, beta 1.63434
FAM76A family with sequence similarity 76, member A 1.63409
DRG1 developmentally regulated GTP binding protein 1 1.63256
LOC145678 uncharacterized LOC145678 1.63236
CARD8 caspase recruitment domain family, member 8 1.62679
RHCE Rh blood group, CcEe antigens 1.62317
PLK1 polo-like kinase 1 1.61884
GAB2 GRB2-associated binding protein 2 1.61854
COIL coilin 1.60321
MBL1P mannose-binding lectin (protein A) 1, pseudogene 1.60033
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa 1.59616
ARSB arylsulfatase B 1.59518
KRT16 keratin 16, type I 1.59283
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 1.59142
TPD52 tumor protein D52 1.59096
CLP1 cleavage and polyadenylation factor I subunit 1 1.58524
MEP1B meprin A, beta 1.58118
TMEM106C transmembrane protein 106C 1.58028
CDC14A cell division cycle 14A 1.57985
NQO1 NAD(P)H dehydrogenase, quinone 1 1.57928
IRF2BP1 interferon regulatory factor 2 binding protein 1 1.57702
TYMS thymidylate synthetase 1.57545
TOM1 target of myb1 (chicken) 1.57266
GMPR guanosine monophosphate reductase 1.57247
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.57044
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.56551
CLDN10 claudin 10 1.56406
ISG20 interferon stimulated exonuclease gene 20kDa 1.564
PLEKHO2 pleckstrin homology domain containing, family O member 2 1.56334
F13B coagulation factor XIII, B polypeptide 1.55709
FNDC3A fibronectin type III domain containing 3A 1.55657
ZNF516 zinc finger protein 516 1.5523
STATH statherin 1.55199
NGDN neuroguidin, EIF4E binding protein 1.54782
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 1.54619
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 1.54557
IGHV5-78 immunoglobulin heavy variable 5-78 (pseudogene) 1.5448
ANXA9 annexin A9 1.54282
FANCC Fanconi anemia, complementation group C 1.54193
NR5A2 nuclear receptor subfamily 5, group A, member 2 1.53902
ZNF330 zinc finger protein 330 1.53848
SPINT3 serine peptidase inhibitor, Kunitz type, 3 1.53769
GALK1 galactokinase 1 1.5372
ADGRE2 adhesion G protein-coupled receptor E2 1.53649
WISP3 WNT1 inducible signaling pathway protein 3 1.53477
PARD6B par-6 family cell polarity regulator beta 1.53349
GYPE glycophorin E (MNS blood group) 1.53264
DRD1 dopamine receptor D1 1.53167
CCBL2 cysteine conjugate-beta lyase 2 1.53152
STRN striatin, calmodulin binding protein 1.52774
SOX13 SRY (sex determining region Y)-box 13 1.52761
GRIK1 glutamate receptor, ionotropic, kainate 1 1.52303
MAP3K3 mitogen-activated protein kinase kinase kinase 3 1.52102
LMO1 LIM domain only 1 (rhombotin 1) 1.51698
NCKAP1L NCK-associated protein 1-like 1.51488
IL23A interleukin 23, alpha subunit p19 1.51263
TERF2 telomeric repeat binding factor 2 1.51243
GTF2A1 general transcription factor IIA, 1, 19/37kDa 1.51239
PC pyruvate carboxylase 1.51101
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 1.50936
CEP68 centrosomal protein 68kDa 1.50876
BRS3 bombesin-like receptor 3 1.5079
MLH1 mutL homolog 1 1.50641
PPP1R10 protein phosphatase 1, regulatory subunit 10 1.50592
CCNE1 cyclin E1 1.50418
ALMS1 Alstrom syndrome protein 1 1.50284
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 1.50228
CYHR1 cysteine/histidine-rich 1 1.50104
AKAP5 A kinase (PRKA) anchor protein 5 1.49902
TADA2A transcriptional adaptor 2A 1.49628
KIAA0087 KIAA0087 1.49547
TMEM186 transmembrane protein 186 1.49373
XDH xanthine dehydrogenase 1.49244
MCM2 minichromosome maintenance complex component 2 1.49109
MYO16 myosin XVI 1.49085
NOP14-AS1 NOP14 antisense RNA 1 1.48804
GH2 growth hormone 2 1.48602
ZFY zinc finger protein, Y-linked 1.48497
SH3GL3 SH3-domain GRB2-like 3 1.48494
TACR3 tachykinin receptor 3 1.48274
DDO D-aspartate oxidase 1.48105
CAST calpastatin 1.47938
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) 1.47862
MAP2K2 mitogen-activated protein kinase kinase 2 1.47674
WASF2 WAS protein family, member 2 1.47625
VWA5A von Willebrand factor A domain containing 5A 1.47555
NPHP4 nephronophthisis 4 1.47327
C10ORF10 chromosome 10 open reading frame 10 1.47308
P2RY10 purinergic receptor P2Y, G-protein coupled, 10 1.46815
INE2 inactivation escape 2 (non-protein coding) 1.46714
SNTA1 syntrophin, alpha 1 1.46394
CLCA1 chloride channel accessory 1 1.4634
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 1.46324
PSEN1 presenilin 1 1.46213
FAM114A1 family with sequence similarity 114, member A1 1.46015
RBBP8 retinoblastoma binding protein 8 1.45138
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 1.45001
RIMS1 regulating synaptic membrane exocytosis 1 1.44771
SORCS3 sortilin-related VPS10 domain containing receptor 3 1.4444
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.44365
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 1.44323
RGN regucalcin 1.44195
ITPK1 inositol-tetrakisphosphate 1-kinase 1.43981
FAM102A family with sequence similarity 102, member A 1.4394
CLUAP1 clusterin associated protein 1 1.43753
KIAA0430 KIAA0430 1.43627
KLK13 kallikrein-related peptidase 13 1.43578
NEUROG3 neurogenin 3 1.43259
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding) 1.43193
MNX1 motor neuron and pancreas homeobox 1 1.43071
TLR3 toll-like receptor 3 1.4298
DNAH9 dynein, axonemal, heavy chain 9 1.42972
YBX1 Y box binding protein 1 1.4297
TPO thyroid peroxidase 1.42952
OSBPL2 oxysterol binding protein-like 2 1.42876
CEP152 centrosomal protein 152kDa 1.42776
TDRD7 tudor domain containing 7 1.42606
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 1.42594
HDAC5 histone deacetylase 5 1.4248
NET1 neuroepithelial cell transforming 1 1.42382
KIF3C kinesin family member 3C 1.42185
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.4207
TCL1A T-cell leukemia/lymphoma 1A 1.42016
LINC00599 long intergenic non-protein coding RNA 599 1.41971
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 1.41962
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1 1.4196
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 1.419
SIGLEC6 sialic acid binding Ig-like lectin 6 1.41845
LOR loricrin 1.41606
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 1.41579
ADGRE5 adhesion G protein-coupled receptor E5 1.41548
TIAM1 T-cell lymphoma invasion and metastasis 1 1.41368
S100A5 S100 calcium binding protein A5 1.41368
FKBP15 FK506 binding protein 15, 133kDa 1.41339
ETV4 ets variant 4 1.41266
GRM8 glutamate receptor, metabotropic 8 1.41207
ALX3 ALX homeobox 3 1.41026

decreased expression

Symbol Name Standardized Value
KALRN kalirin, RhoGEF kinase -3.55553
ADSS adenylosuccinate synthase -3.11955
BICD1 bicaudal D homolog 1 (Drosophila) -2.89699
RIMS2 regulating synaptic membrane exocytosis 2 -2.88633
NFE2L3 nuclear factor, erythroid 2-like 3 -2.8108
AFP alpha-fetoprotein -2.77229
REL v-rel avian reticuloendotheliosis viral oncogene homolog -2.75781
HDAC6 histone deacetylase 6 -2.75614
LOC100129973 uncharacterized LOC100129973 -2.70079
BAGE B melanoma antigen -2.6999
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2 -2.66218
GPR50 G protein-coupled receptor 50 -2.66207
PIGA phosphatidylinositol glycan anchor biosynthesis, class A -2.65509
COX20 COX20 cytochrome c oxidase assembly factor -2.57634
IDS iduronate 2-sulfatase -2.5502
PTPRC protein tyrosine phosphatase, receptor type, C -2.53711
MAP3K9 mitogen-activated protein kinase kinase kinase 9 -2.49977
NOX1 NADPH oxidase 1 -2.49933
LARGE like-glycosyltransferase -2.49637
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) -2.47002
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein -2.46544
ASTN1 astrotactin 1 -2.45929
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 -2.44105
RPIA ribose 5-phosphate isomerase A -2.43436
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 -2.42548
GCKR glucokinase (hexokinase 4) regulator -2.4247
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma -2.42401
DLX4 distal-less homeobox 4 -2.4088
ZNF710 zinc finger protein 710 -2.40473
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 -2.39189
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -2.39029
FZD5 frizzled class receptor 5 -2.37726
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 -2.35642
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 -2.33174
SELPLG selectin P ligand -2.30409
NEU3 sialidase 3 (membrane sialidase) -2.30268
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 -2.29139
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2 -2.26169
COL19A1 collagen, type XIX, alpha 1 -2.2571
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -2.25026
CSDC2 cold shock domain containing C2, RNA binding -2.23091
AVIL advillin -2.205
HSPH1 heat shock 105kDa/110kDa protein 1 -2.20248
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2 -2.19881
CDK3 cyclin-dependent kinase 3 -2.18758
CNKSR1 connector enhancer of kinase suppressor of Ras 1 -2.16285
IGHMBP2 immunoglobulin mu binding protein 2 -2.15901
SCGB1D2 secretoglobin, family 1D, member 2 -2.1568
PHTF1 putative homeodomain transcription factor 1 -2.13778
TTPA tocopherol (alpha) transfer protein -2.13497
RNF8 ring finger protein 8, E3 ubiquitin protein ligase -2.12345
LRRC8B leucine rich repeat containing 8 family, member B -2.11729
TTLL3 tubulin tyrosine ligase-like family member 3 -2.11623
LRP6 low density lipoprotein receptor-related protein 6 -2.1156
USP6 ubiquitin specific peptidase 6 -2.11385
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.11277
DSC3 desmocollin 3 -2.10543
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) -2.10471
IFNA5 interferon, alpha 5 -2.10364
AHCTF1 AT hook containing transcription factor 1 -2.10338
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) -2.08209
CRYGD crystallin, gamma D -2.07046
ATP7A ATPase, Cu++ transporting, alpha polypeptide -2.06869
PWP2 PWP2 periodic tryptophan protein homolog (yeast) -2.06403
CALCR calcitonin receptor -2.05974
RFX5 regulatory factor X, 5 (influences HLA class II expression) -2.05713
SKAP1 src kinase associated phosphoprotein 1 -2.05559
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -2.05443
ZNF124 zinc finger protein 124 -2.04694
EPM2AIP1 EPM2A (laforin) interacting protein 1 -2.03057
CD36 CD36 molecule (thrombospondin receptor) -2.0218
VASP vasodilator-stimulated phosphoprotein -2.01877
TFIP11 tuftelin interacting protein 11 -2.01112
CR1L complement component (3b/4b) receptor 1-like -2.00507
NECAB2 N-terminal EF-hand calcium binding protein 2 -2.00387
ATP10B ATPase, class V, type 10B -1.99047
RAB27A RAB27A, member RAS oncogene family -1.99027
MECOM MDS1 and EVI1 complex locus -1.98996
GPR15 G protein-coupled receptor 15 -1.98908
HOXB5 homeobox B5 -1.98518
WRN Werner syndrome, RecQ helicase-like -1.98341
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta -1.98221
FOXI1 forkhead box I1 -1.97412
RBFA ribosome binding factor A (putative) -1.9725
ATF7 activating transcription factor 7 -1.97054
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 -1.97048
ATG4A autophagy related 4A, cysteine peptidase -1.96891
PRSS53 protease, serine, 53 -1.96725
CEP290 centrosomal protein 290kDa -1.96184
ELOVL6 ELOVL fatty acid elongase 6 -1.96085
POU3F1 POU class 3 homeobox 1 -1.96051
ARSE arylsulfatase E (chondrodysplasia punctata 1) -1.95544
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D -1.9428
ALK anaplastic lymphoma receptor tyrosine kinase -1.94199
ZNF646 zinc finger protein 646 -1.93387
AGER advanced glycosylation end product-specific receptor -1.92815
OFD1 oral-facial-digital syndrome 1 -1.92567
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -1.91897
DUSP7 dual specificity phosphatase 7 -1.91847
PPP1R12B protein phosphatase 1, regulatory subunit 12B -1.91483
ADGRB2 adhesion G protein-coupled receptor B2 -1.91474
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) -1.90972
GRP gastrin-releasing peptide -1.90957
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) -1.90577
UCKL1 uridine-cytidine kinase 1-like 1 -1.90471
CIB2 calcium and integrin binding family member 2 -1.90417
UBE3A ubiquitin protein ligase E3A -1.90029
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -1.89557
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 -1.89244
XK X-linked Kx blood group -1.88876
MANF mesencephalic astrocyte-derived neurotrophic factor -1.88277
SLC4A3 solute carrier family 4 (anion exchanger), member 3 -1.8804
DHODH dihydroorotate dehydrogenase (quinone) -1.87817
PCDHGB7 protocadherin gamma subfamily B, 7 -1.87568
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 -1.87542
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) -1.86817
KRT4 keratin 4, type II -1.86413
TOP3A topoisomerase (DNA) III alpha -1.85767
LST1 leukocyte specific transcript 1 -1.8535
CCDC64 coiled-coil domain containing 64 -1.85125
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae) -1.84741
DHRS2 dehydrogenase/reductase (SDR family) member 2 -1.84449
PDGFB platelet-derived growth factor beta polypeptide -1.83578
CD79B CD79b molecule, immunoglobulin-associated beta -1.82931
RUNDC3A RUN domain containing 3A -1.82563
ITGA8 integrin, alpha 8 -1.822
PDCD2 programmed cell death 2 -1.82017
WWP1 WW domain containing E3 ubiquitin protein ligase 1 -1.81819
HIST1H1T histone cluster 1, H1t -1.81482
HTN3 histatin 3 -1.81233
NOP14 NOP14 nucleolar protein -1.81226
HOXB7 homeobox B7 -1.80937
CDK13 cyclin-dependent kinase 13 -1.80888
SFPQ splicing factor proline/glutamine-rich -1.80862
PLXDC1 plexin domain containing 1 -1.808
ERI2 ERI1 exoribonuclease family member 2 -1.7981
MCC mutated in colorectal cancers -1.79781
ZNF23 zinc finger protein 23 -1.79661
CRH corticotropin releasing hormone -1.79543
PRKCI protein kinase C, iota -1.79528
PRDM2 PR domain containing 2, with ZNF domain -1.78878
ASCC3 activating signal cointegrator 1 complex subunit 3 -1.78586
GPC3 glypican 3 -1.77689
IGF1 insulin-like growth factor 1 (somatomedin C) -1.7704
TGDS TDP-glucose 4,6-dehydratase -1.76743
TMEM63A transmembrane protein 63A -1.76235
REN renin -1.75996
OSGEP O-sialoglycoprotein endopeptidase -1.75848
BAIAP3 BAI1-associated protein 3 -1.7558
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 -1.7496
PRKCD protein kinase C, delta -1.74615
PRKX protein kinase, X-linked -1.74506
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -1.74498
SPTA1 spectrin, alpha, erythrocytic 1 -1.74411
HIC2 hypermethylated in cancer 2 -1.74135
RAP1GAP2 RAP1 GTPase activating protein 2 -1.74103
ZNF274 zinc finger protein 274 -1.74022
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -1.73967
PRL prolactin -1.737
SSPN sarcospan -1.73533
EDDM3A epididymal protein 3A -1.73147
SIN3B SIN3 transcription regulator family member B -1.73021
YLPM1 YLP motif containing 1 -1.72574
ST20 suppressor of tumorigenicity 20 -1.7256
ENPEP glutamyl aminopeptidase (aminopeptidase A) -1.72474
TLR5 toll-like receptor 5 -1.7194
CTNNA2 catenin (cadherin-associated protein), alpha 2 -1.71443
SRRM2 serine/arginine repetitive matrix 2 -1.71156
CARTPT CART prepropeptide -1.7094
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1 -1.70788
WT1-AS WT1 antisense RNA -1.70712
TCERG1 transcription elongation regulator 1 -1.70502
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 -1.70423
PPP2R2B protein phosphatase 2, regulatory subunit B, beta -1.69873
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 -1.6914
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 -1.69024
ERBB4 erb-b2 receptor tyrosine kinase 4 -1.68745
NRXN2 neurexin 2 -1.68507
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -1.68196
CRYBB1 crystallin, beta B1 -1.67808
HIST1H2AG histone cluster 1, H2ag -1.67585
SYCP1 synaptonemal complex protein 1 -1.6757
GPR20 G protein-coupled receptor 20 -1.67526
TCF15 transcription factor 15 (basic helix-loop-helix) -1.6734
CLTA clathrin, light chain A -1.67317
FRK fyn-related Src family tyrosine kinase -1.66795
OPRM1 opioid receptor, mu 1 -1.66199
RPH3A rabphilin 3A -1.66126
MARK3 MAP/microtubule affinity-regulating kinase 3 -1.65979
UNC93A unc-93 homolog A (C. elegans) -1.65837
F2 coagulation factor II (thrombin) -1.65176
PRPF4B pre-mRNA processing factor 4B -1.65087
NPY5R neuropeptide Y receptor Y5 -1.64952
PGGT1B protein geranylgeranyltransferase type I, beta subunit -1.64768
KIF5C kinesin family member 5C -1.64709
C3AR1 complement component 3a receptor 1 -1.6464
AATK apoptosis-associated tyrosine kinase -1.6461
NPPA natriuretic peptide A -1.64526
PTH parathyroid hormone -1.64161
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2 -1.64127
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -1.63669
IL10 interleukin 10 -1.63525
TBKBP1 TBK1 binding protein 1 -1.63341
WNT8B wingless-type MMTV integration site family, member 8B -1.62957
NHLH2 nescient helix loop helix 2 -1.62887
STX1A syntaxin 1A (brain) -1.62762
CHN1 chimerin 1 -1.62436
LIG4 ligase IV, DNA, ATP-dependent -1.62177
MYB v-myb avian myeloblastosis viral oncogene homolog -1.61907
NPHP1 nephronophthisis 1 (juvenile) -1.61789
GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa -1.6176
SKIL SKI-like proto-oncogene -1.61705
HBE1 hemoglobin, epsilon 1 -1.61683
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -1.6159
HMOX2 heme oxygenase 2 -1.61442
SF3B1 splicing factor 3b, subunit 1, 155kDa -1.61383
MEGF6 multiple EGF-like-domains 6 -1.60854
FMO4 flavin containing monooxygenase 4 -1.60745
CHM choroideremia (Rab escort protein 1) -1.60349
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 -1.60169
SREK1IP1 SREK1-interacting protein 1 -1.60054
HOMER1 homer scaffolding protein 1 -1.60001
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 -1.59845
STX16 syntaxin 16 -1.59456
DLK1 delta-like 1 homolog (Drosophila) -1.59417
SHOX short stature homeobox -1.59151
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene) -1.58928
TGM4 transglutaminase 4 -1.58897
PCDHGA8 protocadherin gamma subfamily A, 8 -1.58886
GCA grancalcin, EF-hand calcium binding protein -1.58762
GPR3 G protein-coupled receptor 3 -1.58592
NKX3-2 NK3 homeobox 2 -1.57719
MPZ myelin protein zero -1.57649
ZNF211 zinc finger protein 211 -1.57322
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -1.57178
OLIG2 oligodendrocyte lineage transcription factor 2 -1.56611
PLK3 polo-like kinase 3 -1.56498
GPR182 G protein-coupled receptor 182 -1.56474
SF1 splicing factor 1 -1.56395
CNTN5 contactin 5 -1.56148
PXDC1 PX domain containing 1 -1.56087
TRAF5 TNF receptor-associated factor 5 -1.55834
HMGXB3 HMG box domain containing 3 -1.55693
SMA4 glucuronidase, beta pseudogene -1.5569
HMBS hydroxymethylbilane synthase -1.55573
PNLIPRP1 pancreatic lipase-related protein 1 -1.55166
ADAM7 ADAM metallopeptidase domain 7 -1.54869
EXTL1 exostosin-like glycosyltransferase 1 -1.54306
WDR77 WD repeat domain 77 -1.53789
CBX3 chromobox homolog 3 -1.53318
PSCA prostate stem cell antigen -1.53094
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 -1.52915
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4 -1.52873
IFNA2 interferon, alpha 2 -1.52778
CHEK2 checkpoint kinase 2 -1.52472
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) -1.52288
LAD1 ladinin 1 -1.52243
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled -1.51886
IGKV1OR2-118 immunoglobulin kappa variable 1/OR2-118 (pseudogene) -1.51605
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -1.51602
LCE2B late cornified envelope 2B -1.51459
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 -1.51438
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit -1.51397
TRAF4 TNF receptor-associated factor 4 -1.51202
TRAIP TRAF interacting protein -1.51147
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) -1.50945
F7 coagulation factor VII (serum prothrombin conversion accelerator) -1.50939
HLA-DMB major histocompatibility complex, class II, DM beta -1.50782
MUC3A mucin 3A, cell surface associated -1.50224
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 -1.49592
ANKRD6 ankyrin repeat domain 6 -1.49584
KIAA0930 KIAA0930 -1.49565
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 -1.49429
KIN Kin17 DNA and RNA binding protein -1.49382
ZNF239 zinc finger protein 239 -1.49289
ACOT11 acyl-CoA thioesterase 11 -1.49212
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit -1.49095
ACOX3 acyl-CoA oxidase 3, pristanoyl -1.49013
KRT17 keratin 17, type I -1.48992
IGSF9B immunoglobulin superfamily, member 9B -1.48833
CSF3R colony stimulating factor 3 receptor (granulocyte) -1.48764
TRPM1 transient receptor potential cation channel, subfamily M, member 1 -1.48694
ARID4A AT rich interactive domain 4A (RBP1-like) -1.48404
PAH phenylalanine hydroxylase -1.48373
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide -1.48275
DRP2 dystrophin related protein 2 -1.48167
PTPRD protein tyrosine phosphatase, receptor type, D -1.48088
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -1.4802
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -1.47821
PLCB4 phospholipase C, beta 4 -1.4773
CLK3 CDC-like kinase 3 -1.47606
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 -1.47506
PADI2 peptidyl arginine deiminase, type II -1.47442
GCM1 glial cells missing homolog 1 (Drosophila) -1.47324
SIT1 signaling threshold regulating transmembrane adaptor 1 -1.47266
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -1.4719
SPTB spectrin, beta, erythrocytic -1.47122
CCNH cyclin H -1.46994
GUCY1B3 guanylate cyclase 1, soluble, beta 3 -1.46921
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 -1.46792