Type 1 diabetes mellitus_pancreatic islet_GSE2254 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Diseases
Category transcriptomics
Type disease perturbation
Description disease perturbation identified as [disease]_[tissue]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2254
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Genes

600 genes differentially expressed during Type 1 diabetes mellitus_pancreatic islet_GSE2254 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

increased expression

Symbol Name Standardized Value
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 3.23283
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 3.20909
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 3.19275
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 3.14914
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 3.14603
ORC1 origin recognition complex, subunit 1 3.08485
FOXB1 forkhead box B1 3.00843
IGFBP4 insulin-like growth factor binding protein 4 2.91686
PEX19 peroxisomal biogenesis factor 19 2.78149
PRDM5 PR domain containing 5 2.77418
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 2.69378
BRIX1 BRX1, biogenesis of ribosomes 2.61571
STC1 stanniocalcin 1 2.6018
ULK2 unc-51 like autophagy activating kinase 2 2.58297
HPCAL1 hippocalcin-like 1 2.5594
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 2.46614
TSPAN4 tetraspanin 4 2.46575
SEPT6 septin 6 2.42959
TRPC1 transient receptor potential cation channel, subfamily C, member 1 2.40408
GRIK2 glutamate receptor, ionotropic, kainate 2 2.35241
CLEC16A C-type lectin domain family 16, member A 2.33274
ACSL1 acyl-CoA synthetase long-chain family member 1 2.30629
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 2.28656
MMP15 matrix metallopeptidase 15 (membrane-inserted) 2.28164
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) 2.26972
CCL11 chemokine (C-C motif) ligand 11 2.24549
DAD1 defender against cell death 1 2.24263
SOX6 SRY (sex determining region Y)-box 6 2.23508
DUSP2 dual specificity phosphatase 2 2.22817
TSG101 tumor susceptibility 101 2.22515
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 2.22348
GNA14 guanine nucleotide binding protein (G protein), alpha 14 2.22294
CD82 CD82 molecule 2.22284
NEK6 NIMA-related kinase 6 2.20542
ADGRA3 adhesion G protein-coupled receptor A3 2.19775
OMD osteomodulin 2.18055
NPR3 natriuretic peptide receptor 3 2.16334
IL7 interleukin 7 2.15453
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.14593
SIRPA signal-regulatory protein alpha 2.12659
FER fer (fps/fes related) tyrosine kinase 2.12379
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.12134
NR2C1 nuclear receptor subfamily 2, group C, member 1 2.09441
VIP vasoactive intestinal peptide 2.09199
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.08944
FICD FIC domain containing 2.08855
ASTN1 astrotactin 1 2.0876
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 2.0756
GLA galactosidase, alpha 2.07208
ATE1 arginyltransferase 1 2.07115
GPR137B G protein-coupled receptor 137B 2.06199
NGF nerve growth factor (beta polypeptide) 2.05826
SMYD2 SET and MYND domain containing 2 2.05293
C2CD2 C2 calcium-dependent domain containing 2 2.04935
MKRN3 makorin ring finger protein 3 2.04733
PHOSPHO2 phosphatase, orphan 2 2.03724
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 2.02892
DHRS7B dehydrogenase/reductase (SDR family) member 7B 2.01939
RAB23 RAB23, member RAS oncogene family 2.01314
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 2.01195
LIMD2 LIM domain containing 2 2.01083
CSTB cystatin B (stefin B) 1.99731
NPAS2 neuronal PAS domain protein 2 1.99618
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 1.9955
CLCN5 chloride channel, voltage-sensitive 5 1.99495
INSIG1 insulin induced gene 1 1.97767
DNM3 dynamin 3 1.962
MMP3 matrix metallopeptidase 3 1.96057
TUBB6 tubulin, beta 6 class V 1.96048
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.95838
SULT1C3 sulfotransferase family, cytosolic, 1C, member 3 1.95737
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 1.93475
MRPL11 mitochondrial ribosomal protein L11 1.92954
KRT25 keratin 25, type I 1.92446
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 1.92084
NTPCR nucleoside-triphosphatase, cancer-related 1.91329
C2 complement component 2 1.89462
CLVS1 clavesin 1 1.88008
FBN1 fibrillin 1 1.87121
TAL1 T-cell acute lymphocytic leukemia 1 1.85992
IDE insulin-degrading enzyme 1.85918
CTSC cathepsin C 1.859
CLN3 ceroid-lipofuscinosis, neuronal 3 1.85687
CSNK1D casein kinase 1, delta 1.85633
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 1.85607
POMT1 protein-O-mannosyltransferase 1 1.85394
PACRGL PARK2 co-regulated-like 1.84866
C1R complement component 1, r subcomponent 1.84767
SORBS1 sorbin and SH3 domain containing 1 1.84354
NDFIP2 Nedd4 family interacting protein 2 1.83435
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 1.83193
RAB31 RAB31, member RAS oncogene family 1.8251
UBAP2 ubiquitin associated protein 2 1.82501
LHX9 LIM homeobox 9 1.82446
LARP7 La ribonucleoprotein domain family, member 7 1.8237
MARCKSL1 MARCKS-like 1 1.82362
DARS aspartyl-tRNA synthetase 1.82238
COX18 COX18 cytochrome c oxidase assembly factor 1.82225
MRPL42 mitochondrial ribosomal protein L42 1.82178
SC5D sterol-C5-desaturase 1.81698
EPHA3 EPH receptor A3 1.81154
ZNF398 zinc finger protein 398 1.81096
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 1.80706
MPG N-methylpurine-DNA glycosylase 1.80598
GRK5 G protein-coupled receptor kinase 5 1.80198
CNIH4 cornichon family AMPA receptor auxiliary protein 4 1.79982
KIAA1161 KIAA1161 1.78862
EIF4E2 eukaryotic translation initiation factor 4E family member 2 1.78832
NDRG4 NDRG family member 4 1.78438
SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 1.77637
PHLDA1 pleckstrin homology-like domain, family A, member 1 1.77283
MYCBP MYC binding protein 1.7492
CSF1 colony stimulating factor 1 (macrophage) 1.73882
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 1.73758
DBN1 drebrin 1 1.73196
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 1.71648
PARM1 prostate androgen-regulated mucin-like protein 1 1.71484
SLCO3A1 solute carrier organic anion transporter family, member 3A1 1.71383
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 1.70824
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 1.70002
UFD1L ubiquitin fusion degradation 1 like (yeast) 1.69837
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 1.69039
LDHB lactate dehydrogenase B 1.68742
ZNF436 zinc finger protein 436 1.68273
NR5A2 nuclear receptor subfamily 5, group A, member 2 1.68076
FBXO6 F-box protein 6 1.68073
NEURL4 neuralized E3 ubiquitin protein ligase 4 1.64942
BAX BCL2-associated X protein 1.64891
CD320 CD320 molecule 1.64723
STAB1 stabilin 1 1.64276
DGCR14 DiGeorge syndrome critical region gene 14 1.64093
BCAS2 breast carcinoma amplified sequence 2 1.63993
MRPL49 mitochondrial ribosomal protein L49 1.63178
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 1.63175
HESX1 HESX homeobox 1 1.62619
CRABP1 cellular retinoic acid binding protein 1 1.62484
RIT1 Ras-like without CAAX 1 1.62405
FRK fyn-related Src family tyrosine kinase 1.62281
BMP10 bone morphogenetic protein 10 1.62102
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 1.6167
KHK ketohexokinase (fructokinase) 1.61428
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 1.61145
LAMA3 laminin, alpha 3 1.60986
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 1.60951
MAP2K6 mitogen-activated protein kinase kinase 6 1.60897
CANT1 calcium activated nucleotidase 1 1.59618
HSPB8 heat shock 22kDa protein 8 1.58309
TET1 tet methylcytosine dioxygenase 1 1.57754
IL18BP interleukin 18 binding protein 1.57735
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 1.57668
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 1.57668
DMP1 dentin matrix acidic phosphoprotein 1 1.56595
MMP17 matrix metallopeptidase 17 (membrane-inserted) 1.56582
PTPN12 protein tyrosine phosphatase, non-receptor type 12 1.56573
REEP1 receptor accessory protein 1 1.56049
MEOX1 mesenchyme homeobox 1 1.55643
FABP6 fatty acid binding protein 6, ileal 1.55567
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 1.55398
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 1.55395
MAB21L2 mab-21-like 2 (C. elegans) 1.55322
THOP1 thimet oligopeptidase 1 1.55042
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) 1.54569
AEBP1 AE binding protein 1 1.54379
RBM6 RNA binding motif protein 6 1.5398
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.53971
BABAM1 BRISC and BRCA1 A complex member 1 1.52431
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.52414
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 1.52308
BCL7C B-cell CLL/lymphoma 7C 1.51924
WARS tryptophanyl-tRNA synthetase 1.51921
RIMKLB ribosomal modification protein rimK-like family member B 1.51884
IDUA iduronidase, alpha-L- 1.51787
DMC1 DNA meiotic recombinase 1 1.51747
CYB5R1 cytochrome b5 reductase 1 1.51656
TEN1 TEN1 CST complex subunit 1.50456
BET1 Bet1 golgi vesicular membrane trafficking protein 1.50333
APIP APAF1 interacting protein 1.49666
LAP3 leucine aminopeptidase 3 1.48535
PLP1 proteolipid protein 1 1.48435
NUP93 nucleoporin 93kDa 1.48077
SNCG synuclein, gamma (breast cancer-specific protein 1) 1.47993
TSEN15 TSEN15 tRNA splicing endonuclease subunit 1.4786
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 1.47854
IL12B interleukin 12B 1.47836
ZFAND2A zinc finger, AN1-type domain 2A 1.47778
CIDEA cell death-inducing DFFA-like effector a 1.4755
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 1.46372
NIPSNAP1 nipsnap homolog 1 (C. elegans) 1.46368
TRAFD1 TRAF-type zinc finger domain containing 1 1.46181
FAM50B family with sequence similarity 50, member B 1.46127
MPV17 MpV17 mitochondrial inner membrane protein 1.45678
CD4 CD4 molecule 1.45572
IFRD2 interferon-related developmental regulator 2 1.45104
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 1.45038
CMTM3 CKLF-like MARVEL transmembrane domain containing 3 1.44825
SPA17 sperm autoantigenic protein 17 1.44229
RRAGD Ras-related GTP binding D 1.44213
CER1 cerberus 1, DAN family BMP antagonist 1.44158
CR2 complement component (3d/Epstein Barr virus) receptor 2 1.43907
MYOM1 myomesin 1 1.43777
SHMT1 serine hydroxymethyltransferase 1 (soluble) 1.43719
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 1.43566
PDCD6IP programmed cell death 6 interacting protein 1.43506
GRPR gastrin-releasing peptide receptor 1.43478
TCF19 transcription factor 19 1.43419
PTPRG protein tyrosine phosphatase, receptor type, G 1.43149
C9ORF91 chromosome 9 open reading frame 91 1.43132
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 1.42912
TMEM5 transmembrane protein 5 1.42744
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 1.42658
IFITM3 interferon induced transmembrane protein 3 1.42406
IL2RG interleukin 2 receptor, gamma 1.41417
SCN8A sodium channel, voltage gated, type VIII alpha subunit 1.41342
ANKRD40 ankyrin repeat domain 40 1.41295
GSC goosecoid homeobox 1.40908
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.40887
LOC100129361 1.40412
MYH11 myosin, heavy chain 11, smooth muscle 1.40225
MCM10 minichromosome maintenance complex component 10 1.40055
ZDHHC6 zinc finger, DHHC-type containing 6 1.40027
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) 1.39974
MRPS5 mitochondrial ribosomal protein S5 1.3973
CLIP1 CAP-GLY domain containing linker protein 1 1.39174
PPP5C protein phosphatase 5, catalytic subunit 1.38806
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa 1.38432
FAM71D family with sequence similarity 71, member D 1.38348
GALC galactosylceramidase 1.38041
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q 1.38032
LONP1 lon peptidase 1, mitochondrial 1.37946
VEGFC vascular endothelial growth factor C 1.37888
TM2D1 TM2 domain containing 1 1.37862
TPRA1 transmembrane protein, adipocyte asscociated 1 1.37823
MMP10 matrix metallopeptidase 10 1.3757
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.37363
ZNF316 zinc finger protein 316 1.37146
PTH1R parathyroid hormone 1 receptor 1.36976
PTPRJ protein tyrosine phosphatase, receptor type, J 1.36909
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) 1.36862
PEX13 peroxisomal biogenesis factor 13 1.36808
ZFR2 zinc finger RNA binding protein 2 1.36663
STARD3 StAR-related lipid transfer (START) domain containing 3 1.36634
NBN nibrin 1.36584
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 1.36173
METTL3 methyltransferase like 3 1.35992
GRIK1 glutamate receptor, ionotropic, kainate 1 1.35886
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 1.35707
YAP1 Yes-associated protein 1 1.35248
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) 1.35026
GAS6 growth arrest-specific 6 1.34961
FOXD1 forkhead box D1 1.3467
LAMA4 laminin, alpha 4 1.34625
LRRC8C leucine rich repeat containing 8 family, member C 1.34381
STMN2 stathmin 2 1.34336
SRPK1 SRSF protein kinase 1 1.33574
PAWR PRKC, apoptosis, WT1, regulator 1.33402
SLC41A1 solute carrier family 41 (magnesium transporter), member 1 1.33273
MLF1 myeloid leukemia factor 1 1.33226
ZNF260 zinc finger protein 260 1.33124
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 1.32793
BLVRA biliverdin reductase A 1.32658
VAC14 Vac14 homolog (S. cerevisiae) 1.32527
LDB1 LIM domain binding 1 1.32452
ABHD5 abhydrolase domain containing 5 1.32449
FAM46A family with sequence similarity 46, member A 1.32353
GNRHR gonadotropin-releasing hormone receptor 1.31979
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 1.31691
ANGPT2 angiopoietin 2 1.31498
AGTRAP angiotensin II receptor-associated protein 1.31408
TGM2 transglutaminase 2 1.31055
NCK1 NCK adaptor protein 1 1.31021
NFU1 NFU1 iron-sulfur cluster scaffold 1.30913
RRM2 ribonucleotide reductase M2 1.3078
ARL2 ADP-ribosylation factor-like 2 1.30706
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.30454
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 1.299
FKBPL FK506 binding protein like 1.2979
ZMAT3 zinc finger, matrin-type 3 1.29784
DPH5 diphthamide biosynthesis 5 1.29659
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.29531
EXT1 exostosin glycosyltransferase 1 1.29486
A2M alpha-2-macroglobulin 1.29152
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 1.29056
TRAPPC5 trafficking protein particle complex 5 1.28998
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 1.28421
SCN9A sodium channel, voltage gated, type IX alpha subunit 1.28206
EREG epiregulin 1.27925
NDNL2 necdin-like 2 1.27791
KLF9 Kruppel-like factor 9 1.27541
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4 1.27539
LIG3 ligase III, DNA, ATP-dependent 1.27489
PEG10 paternally expressed 10 1.27361
CAMSAP1 calmodulin regulated spectrin-associated protein 1 1.27276
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.26917
MRPL41 mitochondrial ribosomal protein L41 1.26565
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 1.26537
TTC7B tetratricopeptide repeat domain 7B 1.26411
ZWINT ZW10 interacting kinetochore protein 1.26134
ELOVL2 ELOVL fatty acid elongase 2 1.25978
PCID2 PCI domain containing 2 1.2597
CHL1 cell adhesion molecule L1-like 1.25874

decreased expression

Symbol Name Standardized Value
RABEPK Rab9 effector protein with kelch motifs -3.91468
TMEM129 transmembrane protein 129, E3 ubiquitin protein ligase -3.37775
ZNF746 zinc finger protein 746 -3.33436
NRG3 neuregulin 3 -3.31965
EPHA7 EPH receptor A7 -3.26165
FHDC1 FH2 domain containing 1 -3.25507
DFNA5 deafness, autosomal dominant 5 -3.25165
CENPE centromere protein E, 312kDa -3.2007
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta -3.15351
DPEP1 dipeptidase 1 (renal) -3.11238
NUMA1 nuclear mitotic apparatus protein 1 -3.06259
C1QTNF3 C1q and tumor necrosis factor related protein 3 -2.96067
TLE4 transducin-like enhancer of split 4 -2.92714
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 -2.90047
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog -2.89521
GUCY2C guanylate cyclase 2C -2.88576
UBE2T ubiquitin-conjugating enzyme E2T -2.84463
PARD3 par-3 family cell polarity regulator -2.82739
DNASE1L2 deoxyribonuclease I-like 2 -2.82335
RSPO2 R-spondin 2 -2.7815
SCAF8 SR-related CTD-associated factor 8 -2.73962
ZNF503 zinc finger protein 503 -2.72642
VSNL1 visinin-like 1 -2.72147
GLP2R glucagon-like peptide 2 receptor -2.71633
AKR1E2 aldo-keto reductase family 1, member E2 -2.71045
CCDC28B coiled-coil domain containing 28B -2.70948
AREG amphiregulin -2.68637
FGF18 fibroblast growth factor 18 -2.68513
UBE2O ubiquitin-conjugating enzyme E2O -2.67697
MYH6 myosin, heavy chain 6, cardiac muscle, alpha -2.67276
HEMGN hemogen -2.67179
CNTN3 contactin 3 (plasmacytoma associated) -2.66934
KPNA6 karyopherin alpha 6 (importin alpha 7) -2.6658
HIPK2 homeodomain interacting protein kinase 2 -2.66325
FOXC1 forkhead box C1 -2.63679
ATRX alpha thalassemia/mental retardation syndrome X-linked -2.62247
ELAVL2 ELAV like neuron-specific RNA binding protein 2 -2.61753
AMBRA1 autophagy/beclin-1 regulator 1 -2.60877
GSTK1 glutathione S-transferase kappa 1 -2.59803
ZNF282 zinc finger protein 282 -2.5804
DHFR dihydrofolate reductase -2.57937
CORIN corin, serine peptidase -2.56021
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.54016
GUF1 GUF1 GTPase homolog (S. cerevisiae) -2.52853
MEF2C myocyte enhancer factor 2C -2.52848
MKNK2 MAP kinase interacting serine/threonine kinase 2 -2.51799
GCSAM germinal center-associated, signaling and motility -2.51248
MTMR14 myotubularin related protein 14 -2.47093
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 -2.47062
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) -2.46137
COL4A5 collagen, type IV, alpha 5 -2.44949
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 -2.44656
WNT10B wingless-type MMTV integration site family, member 10B -2.4335
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 -2.42452
TCF20 transcription factor 20 (AR1) -2.41541
NMT2 N-myristoyltransferase 2 -2.39871
RBKS ribokinase -2.39253
KIF22 kinesin family member 22 -2.38782
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -2.3765
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -2.37139
VCP valosin containing protein -2.36518
CMKLR1 chemerin chemokine-like receptor 1 -2.36362
CCDC94 coiled-coil domain containing 94 -2.3401
PLA2R1 phospholipase A2 receptor 1, 180kDa -2.33708
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase -2.33665
ENDOU endonuclease, polyU-specific -2.3049
RUSC1 RUN and SH3 domain containing 1 -2.30486
DHCR24 24-dehydrocholesterol reductase -2.30394
KLF17 Kruppel-like factor 17 -2.3015
FABP9 fatty acid binding protein 9, testis -2.3005
TRAF5 TNF receptor-associated factor 5 -2.2912
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -2.28883
WWP2 WW domain containing E3 ubiquitin protein ligase 2 -2.28314
SH3GLB1 SH3-domain GRB2-like endophilin B1 -2.2702
FGF7 fibroblast growth factor 7 -2.26947
KPNA4 karyopherin alpha 4 (importin alpha 3) -2.26625
ASL argininosuccinate lyase -2.26447
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -2.26307
HNF4G hepatocyte nuclear factor 4, gamma -2.25421
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -2.25011
BTC betacellulin -2.2464
GPR143 G protein-coupled receptor 143 -2.24139
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 -2.21543
CHERP calcium homeostasis endoplasmic reticulum protein -2.20507
TGFA transforming growth factor, alpha -2.19899
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) -2.19617
ZFP30 ZFP30 zinc finger protein -2.19255
RIC8A RIC8 guanine nucleotide exchange factor A -2.19188
RNASEH1 ribonuclease H1 -2.1917
GLDC glycine dehydrogenase (decarboxylating) -2.19071
KDM5D lysine (K)-specific demethylase 5D -2.18777
AADAT aminoadipate aminotransferase -2.18619
DBNL drebrin-like -2.18043
ADAM12 ADAM metallopeptidase domain 12 -2.17365
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 -2.16975
QRICH1 glutamine-rich 1 -2.16958
ZNF638 zinc finger protein 638 -2.16218
WDFY2 WD repeat and FYVE domain containing 2 -2.15923
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) -2.15512
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 -2.15053
PMPCA peptidase (mitochondrial processing) alpha -2.14529
GJB6 gap junction protein, beta 6, 30kDa -2.14463
GATA6 GATA binding protein 6 -2.11456
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -2.11138
SNW1 SNW domain containing 1 -2.0905
HAO2 hydroxyacid oxidase 2 (long chain) -2.0807
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 -2.06851
FMO5 flavin containing monooxygenase 5 -2.06103
CLDN6 claudin 6 -2.06013
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 -2.05676
TERF2IP telomeric repeat binding factor 2, interacting protein -2.05294
MELK maternal embryonic leucine zipper kinase -2.03978
GOLGA2 golgin A2 -2.02553
EMC10 ER membrane protein complex subunit 10 -2.02072
LPIN2 lipin 2 -2.01928
MMP8 matrix metallopeptidase 8 -2.00982
APOF apolipoprotein F -2.00952
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -2.00793
WISP1 WNT1 inducible signaling pathway protein 1 -2.00482
PTDSS2 phosphatidylserine synthase 2 -1.99487
OCA2 oculocutaneous albinism II -1.98202
SYCP1 synaptonemal complex protein 1 -1.96788
RBM26 RNA binding motif protein 26 -1.96787
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) -1.96623
HIST1H2BA histone cluster 1, H2ba -1.94211
MRC1 mannose receptor, C type 1 -1.93831
IL13RA2 interleukin 13 receptor, alpha 2 -1.93264
NACA nascent polypeptide-associated complex alpha subunit -1.92809
RPS15 ribosomal protein S15 -1.92467
IVD isovaleryl-CoA dehydrogenase -1.91558
NEO1 neogenin 1 -1.90602
SEPT10 septin 10 -1.90108
SLC25A44 solute carrier family 25, member 44 -1.89901
ELL elongation factor RNA polymerase II -1.89573
TRDMT1 tRNA aspartic acid methyltransferase 1 -1.89465
TRIM47 tripartite motif containing 47 -1.88955
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -1.888
ADGRE1 adhesion G protein-coupled receptor E1 -1.88608
NCOR2 nuclear receptor corepressor 2 -1.87688
LRRC6 leucine rich repeat containing 6 -1.87589
RFC3 replication factor C (activator 1) 3, 38kDa -1.87049
APLP1 amyloid beta (A4) precursor-like protein 1 -1.86521
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -1.86463
RYR1 ryanodine receptor 1 (skeletal) -1.86278
MCOLN1 mucolipin 1 -1.84157
TUFM Tu translation elongation factor, mitochondrial -1.83564
TIPIN TIMELESS interacting protein -1.83182
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 -1.8293
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -1.82885
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 -1.82819
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 -1.82688
TBX3 T-box 3 -1.82321
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 -1.82299
GALM galactose mutarotase (aldose 1-epimerase) -1.82239
ADA adenosine deaminase -1.81784
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) -1.81669
SAP30 Sin3A-associated protein, 30kDa -1.81282
MNAT1 MNAT CDK-activating kinase assembly factor 1 -1.8067
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -1.79806
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like -1.79736
EDIL3 EGF-like repeats and discoidin I-like domains 3 -1.79379
TENM2 teneurin transmembrane protein 2 -1.79359
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -1.79356
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 -1.79036
NFYC nuclear transcription factor Y, gamma -1.7895
NCOA3 nuclear receptor coactivator 3 -1.78819
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -1.78198
CDX4 caudal type homeobox 4 -1.77293
SMAD7 SMAD family member 7 -1.77098
ORMDL1 ORMDL sphingolipid biosynthesis regulator 1 -1.76857
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -1.76851
PREP prolyl endopeptidase -1.7681
SNAI2 snail family zinc finger 2 -1.7643
USP12 ubiquitin specific peptidase 12 -1.75239
NCF2 neutrophil cytosolic factor 2 -1.75116
CDK14 cyclin-dependent kinase 14 -1.74684
C1ORF105 chromosome 1 open reading frame 105 -1.74682
RGS11 regulator of G-protein signaling 11 -1.74645
KPNB1 karyopherin (importin) beta 1 -1.74575
CD7 CD7 molecule -1.74329
TADA3 transcriptional adaptor 3 -1.73982
RPTN repetin -1.73744
AOC3 amine oxidase, copper containing 3 -1.73413
TMEM222 transmembrane protein 222 -1.73396
ODF2L outer dense fiber of sperm tails 2-like -1.73248
RAG2 recombination activating gene 2 -1.72474
PYGB phosphorylase, glycogen; brain -1.72088
HSF2 heat shock transcription factor 2 -1.71481
TXNRD2 thioredoxin reductase 2 -1.71414
MTOR mechanistic target of rapamycin (serine/threonine kinase) -1.70928
DPP4 dipeptidyl-peptidase 4 -1.70661
MOGAT2 monoacylglycerol O-acyltransferase 2 -1.69979
EPHA5 EPH receptor A5 -1.69674
COL19A1 collagen, type XIX, alpha 1 -1.693
OSBP oxysterol binding protein -1.69076
AP1G2 adaptor-related protein complex 1, gamma 2 subunit -1.68935
TSC1 tuberous sclerosis 1 -1.68919
HIST1H1T histone cluster 1, H1t -1.68412
IKZF1 IKAROS family zinc finger 1 (Ikaros) -1.67615
NFIL3 nuclear factor, interleukin 3 regulated -1.67579
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit -1.67434
CAMK2D calcium/calmodulin-dependent protein kinase II delta -1.67154
SWAP70 SWAP switching B-cell complex 70kDa subunit -1.66501
PON1 paraoxonase 1 -1.66038
ACP1 acid phosphatase 1, soluble -1.65975
RAB3IP RAB3A interacting protein -1.65834
AP2A2 adaptor-related protein complex 2, alpha 2 subunit -1.6557
KRT77 keratin 77, type II -1.65486
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 -1.6533
ACYP2 acylphosphatase 2, muscle type -1.64461
TMEM70 transmembrane protein 70 -1.64378
CXCR3 chemokine (C-X-C motif) receptor 3 -1.64355
SDF2 stromal cell-derived factor 2 -1.64033
SH3RF1 SH3 domain containing ring finger 1 -1.63874
CYTH1 cytohesin 1 -1.63725
KIAA0101 KIAA0101 -1.63607
ACVR2A activin A receptor, type IIA -1.63495
FLT3 fms-related tyrosine kinase 3 -1.63389
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 -1.63257
STK38 serine/threonine kinase 38 -1.63007
TMEM98 transmembrane protein 98 -1.62844
MYL4 myosin, light chain 4, alkali; atrial, embryonic -1.62765
TRMT10A tRNA methyltransferase 10 homolog A (S. cerevisiae) -1.62739
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -1.62645
S100A10 S100 calcium binding protein A10 -1.62459
ADCK1 aarF domain containing kinase 1 -1.61803
CCNJ cyclin J -1.61733
RPL37A ribosomal protein L37a -1.61629
NEFL neurofilament, light polypeptide -1.61008
SKA2 spindle and kinetochore associated complex subunit 2 -1.60867
CD22 CD22 molecule -1.60854
AQR aquarius intron-binding spliceosomal factor -1.60684
HDAC7 histone deacetylase 7 -1.60406
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 -1.60289
CSK c-src tyrosine kinase -1.60073
LRP6 low density lipoprotein receptor-related protein 6 -1.59185
GABPB1 GA binding protein transcription factor, beta subunit 1 -1.59008
IFNGR1 interferon gamma receptor 1 -1.58956
SCAF11 SR-related CTD-associated factor 11 -1.58831
HAPLN1 hyaluronan and proteoglycan link protein 1 -1.58638
PHF7 PHD finger protein 7 -1.58574
FGFR2 fibroblast growth factor receptor 2 -1.58527
SNX17 sorting nexin 17 -1.58445
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 -1.58434
FNTB farnesyltransferase, CAAX box, beta -1.58263
PDPN podoplanin -1.57995
ST7-AS2 ST7 antisense RNA 2 -1.57931
FAF1 Fas (TNFRSF6) associated factor 1 -1.57815
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa -1.57782
PTPRA protein tyrosine phosphatase, receptor type, A -1.5778
KIFC3 kinesin family member C3 -1.57288
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -1.56991
CD72 CD72 molecule -1.56709
NAV1 neuron navigator 1 -1.56449
SLPI secretory leukocyte peptidase inhibitor -1.564
ZPBP zona pellucida binding protein -1.56365
BMP8A bone morphogenetic protein 8a -1.5636
MEIG1 meiosis/spermiogenesis associated 1 -1.56298
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene) -1.56221
IRX3 iroquois homeobox 3 -1.56026
TTK TTK protein kinase -1.55959
TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) -1.55741
GRWD1 glutamate-rich WD repeat containing 1 -1.55419
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -1.55254
CMC4 C-x(9)-C motif containing 4 -1.55202
UMOD uromodulin -1.54944
MAP3K3 mitogen-activated protein kinase kinase kinase 3 -1.54733
CAMLG calcium modulating ligand -1.54329
FANCM Fanconi anemia, complementation group M -1.54016
NET1 neuroepithelial cell transforming 1 -1.53821
SH2B3 SH2B adaptor protein 3 -1.53371
NRL neural retina leucine zipper -1.5332
SRPK3 SRSF protein kinase 3 -1.52753
SYNJ2 synaptojanin 2 -1.52631
STYX serine/threonine/tyrosine interacting protein -1.52591
ADCY9 adenylate cyclase 9 -1.52569
ALOX15B arachidonate 15-lipoxygenase, type B -1.5246
RBM15 RNA binding motif protein 15 -1.52394
SNRNP27 small nuclear ribonucleoprotein 27kDa (U4/U6.U5) -1.52136
COIL coilin -1.52062
HIST1H3C histone cluster 1, H3c -1.51919
BPIFB1 BPI fold containing family B, member 1 -1.51347
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 -1.51323
FAM189B family with sequence similarity 189, member B -1.51232
NDP Norrie disease (pseudoglioma) -1.50916
C14ORF2 chromosome 14 open reading frame 2 -1.50855
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 -1.50611
KCTD9 potassium channel tetramerization domain containing 9 -1.50601
H2AFX H2A histone family, member X -1.50545
ZNF277 zinc finger protein 277 -1.50344
CD36 CD36 molecule (thrombospondin receptor) -1.49974
PADI2 peptidyl arginine deiminase, type II -1.49935
ZFP2 ZFP2 zinc finger protein -1.49777
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) -1.49765
TSPAN6 tetraspanin 6 -1.49663
USP22 ubiquitin specific peptidase 22 -1.49618
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -1.49544
USP29 ubiquitin specific peptidase 29 -1.49262
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 -1.49245
ESYT1 extended synaptotagmin-like protein 1 -1.49022