Tumor Necrosis Factor-alpha Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description Tumor necrosis factor (TNF, cachexin or cachectin formerly known as tumor necrosis factor-alpha or TNF-α) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by other cell types as well. (Experimental Factor Ontology, EFO_0003271)
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Genes

13 genes associated with the trait Tumor Necrosis Factor-alpha in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 1.80938
TMEM117 transmembrane protein 117 0.922279
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma 0.781395
PPA1 pyrophosphatase (inorganic) 1 0.769132
WDR70 WD repeat domain 70 0.727392
GLRB glycine receptor, beta 0.660854
MED12L mediator complex subunit 12-like 0.609623
IKZF2 IKAROS family zinc finger 2 (Helios) 0.594434
SPON1 spondin 1, extracellular matrix protein 0.50084
AHCYL2 adenosylhomocysteinase-like 2 0.443956
EMC7 ER membrane protein complex subunit 7 0.141518
AVEN apoptosis, caspase activation inhibitor 0.109886
CHRM5 cholinergic receptor, muscarinic 5 0.109886