Trachoma Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A commensal bacterial infectious disease that results_in infection located_in eye, has_material_basis_in Chlamydia trachomatis (A, B, Ba and C serovars), which is transmitted_by contact with eye discharge from the infected person and transmitted_by congenital method. The infection causes eyelid to turn inward which makes eyelashes to scratch the cornea. (Human Disease Ontology, DOID_11265)
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Genes

43 genes associated with the Trachoma phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ADRB2 adrenoceptor beta 2, surface
C3 complement component 3
C5 complement component 5
CCL11 chemokine (C-C motif) ligand 11
CCR3 chemokine (C-C motif) receptor 3
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
HBB hemoglobin, beta
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HP haptoglobin
ICAM1 intercellular adhesion molecule 1
IL10 interleukin 10
IL13 interleukin 13
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL9 interleukin 9
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
LTA lymphotoxin alpha
LTC4S leukotriene C4 synthase
MBL2 mannose-binding lectin (protein C) 2, soluble
MMP9 matrix metallopeptidase 9
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
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