Torsades de Pointes Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A type of ventricular tachycardia characterized by polymorphioc QRS complexes that change in amplitue and cycle length, and thus have the appearance of oscillating around the baseline in the EKG. (Human Phenotype Ontology, HP_0001664)
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Genes

14 genes associated with the Torsades de Pointes phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
AKAP9 A kinase (PRKA) anchor protein 9
ANK2 ankyrin 2, neuronal
C18ORF21 chromosome 18 open reading frame 21
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
LOXL2 lysyl oxidase-like 2
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
SCN5A sodium channel, voltage gated, type V alpha subunit
SDHAF3 succinate dehydrogenase complex assembly factor 3
STK11 serine/threonine kinase 11