Thyroid Neoplasms Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

352 genes associated with the Thyroid Neoplasms phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACHE acetylcholinesterase (Yt blood group)
ACR acrosin
ADGRV1 adhesion G protein-coupled receptor V1
AIP aryl hydrocarbon receptor interacting protein
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AKR1C4 aldo-keto reductase family 1, member C4
AKR1D1 aldo-keto reductase family 1, member D1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALKBH3 alkB, alkylation repair homolog 3 (E. coli)
ALOX12 arachidonate 12-lipoxygenase
AMH anti-Mullerian hormone
ANXA7 annexin A7
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AR androgen receptor
ARNT aryl hydrocarbon receptor nuclear translocator
ARRB2 arrestin, beta 2
ARSB arylsulfatase B
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATG5 autophagy related 5
ATM ATM serine/threonine kinase
AURKA aurora kinase A
BAD BCL2-associated agonist of cell death
BAK1 BCL2-antagonist/killer 1
BCL2 B-cell CLL/lymphoma 2
BIRC5 baculoviral IAP repeat containing 5
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
CARD9 caspase recruitment domain family, member 9
CASC8 cancer susceptibility candidate 8 (non-protein coding)
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCDC6 coiled-coil domain containing 6
CCL5 chemokine (C-C motif) ligand 5
CCNH cyclin H
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDYL chromodomain protein, Y-like
CGA glycoprotein hormones, alpha polypeptide
CHEK2 checkpoint kinase 2
COMT catechol-O-methyltransferase
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTHRC1 collagen triple helix repeat containing 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DACT3 dishevelled-binding antagonist of beta-catenin 3
DAZL deleted in azoospermia-like
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DIO1 deiodinase, iodothyronine, type I
DIO2 deiodinase, iodothyronine, type II
DIRC3 disrupted in renal carcinoma 3
DMRT1 doublesex and mab-3 related transcription factor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DUOX1 dual oxidase 1
EGFR epidermal growth factor receptor
EP300 E1A binding protein p300
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
ERCC6 excision repair cross-complementation group 6
ERO1LB ERO1-like beta (S. cerevisiae)
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FAF1 Fas (TNFRSF6) associated factor 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FGFR1 fibroblast growth factor receptor 1
FGFR4 fibroblast growth factor receptor 4
FHIT fragile histidine triad
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FN1 fibronectin 1
FOXE1 forkhead box E1
FSHB follicle stimulating hormone, beta polypeptide
FTO fat mass and obesity associated
FZD6 frizzled class receptor 6
GFRA1 GDNF family receptor alpha 1
GFRA2 GDNF family receptor alpha 2
GFRA3 GDNF family receptor alpha 3
GH1 growth hormone 1
GHR growth hormone receptor
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GNRH2 gonadotropin-releasing hormone 2
GNRHR gonadotropin-releasing hormone receptor
GPX3 glutathione peroxidase 3
GREB1 growth regulation by estrogen in breast cancer 1
GSK3B glycogen synthase kinase 3 beta
GSTM1 glutathione S-transferase mu 1
GSTO1 glutathione S-transferase omega 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HAO2 hydroxyacid oxidase 2 (long chain)
HDAC4 histone deacetylase 4
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-G major histocompatibility complex, class I, G
HRAS Harvey rat sarcoma viral oncogene homolog
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
HUS1 HUS1 checkpoint homolog (S. pombe)
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL10 interleukin 10
IL11RA interleukin 11 receptor, alpha
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL21 interleukin 21
IL22 interleukin 22
IL22RA1 interleukin 22 receptor, alpha 1
IL3 interleukin 3
IL31RA interleukin 31 receptor A
IL32 interleukin 32
IL3RA interleukin 3 receptor, alpha (low affinity)
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
INHA inhibin, alpha
INHBB inhibin, beta B
INSL3 insulin-like 3 (Leydig cell)
INSR insulin receptor
IRAK1 interleukin-1 receptor-associated kinase 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGA1 integrin, alpha 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KCNIP3 Kv channel interacting protein 3, calsenilin
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLLN killin, p53-regulated DNA replication inhibitor
KRAS Kirsten rat sarcoma viral oncogene homolog
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LHB luteinizing hormone beta polypeptide
LHCGR luteinizing hormone/choriogonadotropin receptor
LIG4 ligase IV, DNA, ATP-dependent
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAPK1 mitogen-activated protein kinase 1
MATN2 matrilin 2
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED13 mediator complex subunit 13
MIR1468 microRNA 1468
MIR146A microRNA 146a
MIR149 microRNA 149
MIR196A2 microRNA 196a-2
MIR27A microRNA 27a
MIR499A microRNA 499a
MLH1 mutL homolog 1
MMP7 matrix metallopeptidase 7
MSH3 mutS homolog 3
MSS51 MSS51 mitochondrial translational activator
MTF1 metal-regulatory transcription factor 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUTYH mutY homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NBN nibrin
NCOA3 nuclear receptor coactivator 3
NCOA4 nuclear receptor coactivator 4
NCOR2 nuclear receptor corepressor 2
NKX2-1 NK2 homeobox 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR1I2 nuclear receptor subfamily 1, group I, member 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRG1 neuregulin 1
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OGG1 8-oxoguanine DNA glycosylase
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PARP1 poly (ADP-ribose) polymerase 1
PAX8 paired box 8
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDPK1 3-phosphoinositide dependent protein kinase 1
PGR progesterone receptor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLM polymerase (DNA directed), mu
POT1 protection of telomeres 1
PPARG peroxisome proliferator-activated receptor gamma
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRL prolactin
PRLH prolactin releasing hormone
PRLHR prolactin releasing hormone receptor
PRLR prolactin receptor
PTCH1 patched 1
PTCSC3 papillary thyroid carcinoma susceptibility candidate 3 (non-protein coding)
PTEN phosphatase and tensin homolog
PTH1R parathyroid hormone 1 receptor
PTHLH parathyroid hormone-like hormone
PTPRJ protein tyrosine phosphatase, receptor type, J
RAD23B RAD23 homolog B (S. cerevisiae)
RAD51 RAD51 recombinase
RAD52 RAD52 homolog (S. cerevisiae)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RASAL1 RAS protein activator like 1 (GAP1 like)
RET ret proto-oncogene
RHOG ras homolog family member G
RTN3 reticulon 3
RXFP2 relaxin/insulin-like family peptide receptor 2
S100A10 S100 calcium binding protein A10
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SHBG sex hormone-binding globulin
SHH sonic hedgehog
SIAH2 siah E3 ubiquitin protein ligase 2
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
SMAD4 SMAD family member 4
SMAD7 SMAD family member 7
SMO smoothened, frizzled class receptor
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SNX19 sorting nexin 19
SPAG17 sperm associated antigen 17
SPATA13 spermatogenesis associated 13
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1
STAR steroidogenic acute regulatory protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK11 serine/threonine kinase 11
STK17A serine/threonine kinase 17a
STK17B serine/threonine kinase 17b
SULF1 sulfatase 1
SULF2 sulfatase 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
TCF12 transcription factor 12
TERC telomerase RNA component
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TERF2 telomeric repeat binding factor 2
TERT telomerase reverse transcriptase
TG thyroglobulin
THADA thyroid adenoma associated
THRA thyroid hormone receptor, alpha
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TLR1 toll-like receptor 1
TLR10 toll-like receptor 10
TLR6 toll-like receptor 6
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TP53 tumor protein p53
TPO thyroid peroxidase
TPP1 tripeptidyl peptidase I
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRHR thyrotropin-releasing hormone receptor
TRIP11 thyroid hormone receptor interactor 11
TRIP12 thyroid hormone receptor interactor 12
TSHB thyroid stimulating hormone, beta
TSHR thyroid stimulating hormone receptor
TSPAN31 tetraspanin 31
TXNRD2 thioredoxin reductase 2
TYK2 tyrosine kinase 2
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4
UGT1A5 UDP glucuronosyltransferase 1 family, polypeptide A5
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
UGT2B11 UDP glucuronosyltransferase 2 family, polypeptide B11
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VTN vitronectin
VWF von Willebrand factor
WDR3 WD repeat domain 3
WT1 Wilms tumor 1
WWOX WW domain containing oxidoreductase
XAF1 XIAP associated factor 1
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)