Testicular Neoplasms Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D013736
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Genes

298 genes/proteins associated with the disease Testicular Neoplasms from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
KITLG KIT ligand 2.88009
DMRT1 doublesex and mab-3 related transcription factor 1 2.88009
ATF7IP activating transcription factor 7 interacting protein 2.88009
ERCC1 excision repair cross-complementation group 1 2.88009
ERCC4 excision repair cross-complementation group 4 2.88009
FASLG Fas ligand (TNF superfamily, member 6) 1.91435
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.80924
CDK2 cyclin-dependent kinase 2 1.78052
TOP2A topoisomerase (DNA) II alpha 170kDa 1.74501
BAK1 BCL2-antagonist/killer 1 1.728
GADD45A growth arrest and DNA-damage-inducible, alpha 1.7255
VEGFA vascular endothelial growth factor A 1.69513
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.6934
BCL2 B-cell CLL/lymphoma 2 1.68549
GSTP1 glutathione S-transferase pi 1 1.68422
TP53 tumor protein p53 1.66382
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.65424
BAX BCL2-associated X protein 1.65
FOS FBJ murine osteosarcoma viral oncogene homolog 1.63765
GJA1 gap junction protein, alpha 1, 43kDa 1.63676
CCNB1 cyclin B1 1.61389
SOD2 superoxide dismutase 2, mitochondrial 1.59614
PARP1 poly (ADP-ribose) polymerase 1 1.59172
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.58654
FAS Fas cell surface death receptor 1.58421
AURKA aurora kinase A 1.57618
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.54378
NGF nerve growth factor (beta polypeptide) 1.54208
JUN jun proto-oncogene 1.51004
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.50524
IGFBP4 insulin-like growth factor binding protein 4 1.50298
GPX3 glutathione peroxidase 3 1.50172
BCL2L1 BCL2-like 1 1.49941
F3 coagulation factor III (thromboplastin, tissue factor) 1.48761
CAT catalase 1.48068
MGMT O-6-methylguanine-DNA methyltransferase 1.47991
BTG2 BTG family, member 2 1.47991
CCNA2 cyclin A2 1.47889
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.47711
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 1.47452
FOSL1 FOS-like antigen 1 1.46409
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.46146
BTG1 B-cell translocation gene 1, anti-proliferative 1.4612
IL6 interleukin 6 1.45989
CP ceruloplasmin (ferroxidase) 1.45697
DDIT3 DNA-damage-inducible transcript 3 1.45352
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.45063
GPX1 glutathione peroxidase 1 1.44653
CDK1 cyclin-dependent kinase 1 1.44463
EGFR epidermal growth factor receptor 1.43946
CXCL8 chemokine (C-X-C motif) ligand 8 1.43919
TGFB1 transforming growth factor, beta 1 1.43864
BIRC3 baculoviral IAP repeat containing 3 1.43618
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 1.42859
TIMP1 TIMP metallopeptidase inhibitor 1 1.42401
BAD BCL2-associated agonist of cell death 1.40953
CCND1 cyclin D1 1.40429
VIM vimentin 1.40232
IL1B interleukin 1, beta 1.40092
BBC3 BCL2 binding component 3 1.39702
MCL1 myeloid cell leukemia 1 1.39619
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.39507
VCAM1 vascular cell adhesion molecule 1 1.39226
PRC1 protein regulator of cytokinesis 1 1.38724
TYMP thymidine phosphorylase 1.38696
ODC1 ornithine decarboxylase 1 1.38696
BIRC2 baculoviral IAP repeat containing 2 1.38669
IER3 immediate early response 3 1.38327
CFLAR CASP8 and FADD-like apoptosis regulator 1.38327
RRM2 ribonucleotide reductase M2 1.38156
GSTM1 glutathione S-transferase mu 1 1.38156
CYCS cytochrome c, somatic 1.38071
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.37958
MAPK3 mitogen-activated protein kinase 3 1.3793
HMMR hyaluronan-mediated motility receptor (RHAMM) 1.37902
CDK4 cyclin-dependent kinase 4 1.37902
CCND3 cyclin D3 1.37817
PCNA proliferating cell nuclear antigen 1.37504
TNF tumor necrosis factor 1.37332
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.37275
GCLC glutamate-cysteine ligase, catalytic subunit 1.37246
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.3716
MAPK1 mitogen-activated protein kinase 1 1.37018
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.35531
ERBB2 erb-b2 receptor tyrosine kinase 2 1.35444
CD274 CD274 molecule 1.35299
LCN2 lipocalin 2 1.35127
SP1 Sp1 transcription factor 1.34983
CCL2 chemokine (C-C motif) ligand 2 1.34256
CD44 CD44 molecule (Indian blood group) 1.34082
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 1.33701
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.33228
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.32964
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.32935
PRKCD protein kinase C, delta 1.32667
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.32577
IL4 interleukin 4 1.32488
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.32132
RFC5 replication factor C (activator 1) 5, 36.5kDa 1.32044
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 1.30177
RBBP4 retinoblastoma binding protein 4 1.28765
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.2861
HMOX1 heme oxygenase 1 1.28549
EGR2 early growth response 2 1.28241
GDF15 growth differentiation factor 15 1.28027
H2AFX H2A histone family, member X 1.28027
CLU clusterin 1.27162
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.27009
HRAS Harvey rat sarcoma viral oncogene homolog 1.267
MFGE8 milk fat globule-EGF factor 8 protein 1.26514
IFNG interferon, gamma 1.26359
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.26205
CDC20 cell division cycle 20 1.25682
BCAT1 branched chain amino-acid transaminase 1, cytosolic 1.25588
THBS1 thrombospondin 1 1.25525
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.24655
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.24655
HSPA1A heat shock 70kDa protein 1A 1.24655
EGR1 early growth response 1 1.24591
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.24496
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.24181
DNMT1 DNA (cytosine-5-)-methyltransferase 1 1.23993
IRS1 insulin receptor substrate 1 1.23993
IL2 interleukin 2 1.23806
CCNE1 cyclin E1 1.2368
ANXA1 annexin A1 1.2368
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.23616
MMP9 matrix metallopeptidase 9 1.23584
CHEK2 checkpoint kinase 2 1.23042
KLF2 Kruppel-like factor 2 1.23042
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.22566
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 1.22534
WIF1 WNT inhibitory factor 1 1.22469
NQO1 NAD(P)H dehydrogenase, quinone 1 1.22436
SGK1 serum/glucocorticoid regulated kinase 1 1.21919
IL12B interleukin 12B 1.21468
CCND2 cyclin D2 1.21468
E2F1 E2F transcription factor 1 1.21304
MAPK14 mitogen-activated protein kinase 14 1.21271
EMP1 epithelial membrane protein 1 1.21239
AKT2 v-akt murine thymoma viral oncogene homolog 2 1.20751
CAV1 caveolin 1, caveolae protein, 22kDa 1.20262
IGF1R insulin-like growth factor 1 receptor 1.19835
GUSB glucuronidase, beta 1.19047
XAF1 XIAP associated factor 1 1.19047
MAPK8 mitogen-activated protein kinase 8 1.18915
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.18391
GSK3B glycogen synthase kinase 3 beta 1.18159
PLAU plasminogen activator, urokinase 1.18126
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 1.17761
CCNG2 cyclin G2 1.17464
CXCL5 chemokine (C-X-C motif) ligand 5 1.17464
SPP1 secreted phosphoprotein 1 1.17431
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.17333
DIABLO diablo, IAP-binding mitochondrial protein 1.17034
MT2A metallothionein 2A 1.16933
BIRC5 baculoviral IAP repeat containing 5 1.16799
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.16799
HDAC4 histone deacetylase 4 1.165
NOS2 nitric oxide synthase 2, inducible 1.165
HMGB2 high mobility group box 2 1.16401
G0S2 G0/G1 switch 2 1.1617
BIN1 bridging integrator 1 1.16104
RUNX3 runt-related transcription factor 3 1.16104
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.15899
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.15729
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 1.1556
UBE2C ubiquitin-conjugating enzyme E2C 1.15357
ERBB4 erb-b2 receptor tyrosine kinase 4 1.15324
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 1.15324
FSHR follicle stimulating hormone receptor 1.15324
MAP2K1 mitogen-activated protein kinase kinase 1 1.15122
MKI67 marker of proliferation Ki-67 1.15022
CDKN2A cyclin-dependent kinase inhibitor 2A 1.14781
MMP1 matrix metallopeptidase 1 1.14644
CTGF connective tissue growth factor 1.14644
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 1.14473
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 1.14438
INHBA inhibin, beta A 1.1437
COL1A1 collagen, type I, alpha 1 1.1437
PTTG1 pituitary tumor-transforming 1 1.1437
TRIM2 tripartite motif containing 2 1.142
SRGN serglycin 1.142
RPS27L ribosomal protein S27-like 1.14166
PTEN phosphatase and tensin homolog 1.1403
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.13963
SPON1 spondin 1, extracellular matrix protein 1.13827
RB1 retinoblastoma 1 1.13793
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.13793
CTSL cathepsin L 1.13586
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.13449
STAT1 signal transducer and activator of transcription 1, 91kDa 1.13415
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.13211
FGF2 fibroblast growth factor 2 (basic) 1.13075
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.12973
GADD45G growth arrest and DNA-damage-inducible, gamma 1.12634
AK1 adenylate kinase 1 1.12461
PRNP prion protein 1.12461
MELK maternal embryonic leucine zipper kinase 1.12117
TUBA4A tubulin, alpha 4a 1.12117
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.11809
ACKR3 atypical chemokine receptor 3 1.11775
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.11741
DUSP1 dual specificity phosphatase 1 1.11606
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.11396
IL1A interleukin 1, alpha 1.11255
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.11186
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.11046
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 1.11046
CDC25C cell division cycle 25C 1.10872
RAD51 RAD51 recombinase 1.10699
HSPB1 heat shock 27kDa protein 1 1.10596
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.10493
PPARG peroxisome proliferator-activated receptor gamma 1.10388
EPO erythropoietin 1.10353
APAF1 apoptotic peptidase activating factor 1 1.10353
CXCL10 chemokine (C-X-C motif) ligand 10 1.10175
HMGA2 high mobility group AT-hook 2 1.10175
C1QA complement component 1, q subcomponent, A chain 1.09857
DONSON downstream neighbor of SON 1.09786
ACTA2 actin, alpha 2, smooth muscle, aorta 1.09646
ZMAT3 zinc finger, matrin-type 3 1.09541
TERT telomerase reverse transcriptase 1.09506
CCNG1 cyclin G1 1.09366
GADD45B growth arrest and DNA-damage-inducible, beta 1.09366
NPPB natriuretic peptide B 1.09366
AXL AXL receptor tyrosine kinase 1.09297
HIPK2 homeodomain interacting protein kinase 2 1.09262
MAPK9 mitogen-activated protein kinase 9 1.09226
EXOC4 exocyst complex component 4 1.09047
RUNX1 runt-related transcription factor 1 1.08975
TNNI3 troponin I type 3 (cardiac) 1.08975
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.08797
ATP7A ATPase, Cu++ transporting, alpha polypeptide 1.08442
SOCS1 suppressor of cytokine signaling 1 1.08407
RPL6 ribosomal protein L6 1.08407
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 1.08407
CCNB2 cyclin B2 1.08372
MGST1 microsomal glutathione S-transferase 1 1.08231
CENPA centromere protein A 1.0784
BIK BCL2-interacting killer (apoptosis-inducing) 1.0784
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 1.07804
EDNRB endothelin receptor type B 1.07732
TTK TTK protein kinase 1.07589
ATF3 activating transcription factor 3 1.07482
VCAN versican 1.07269
WNT4 wingless-type MMTV integration site family, member 4 1.07022
AKAP12 A kinase (PRKA) anchor protein 12 1.06734
SDC1 syndecan 1 1.06734
CRYAB crystallin, alpha B 1.06661
CD40LG CD40 ligand 1.06479
BDNF brain-derived neurotrophic factor 1.06406
CXCR4 chemokine (C-X-C motif) receptor 4 1.0637
PLAUR plasminogen activator, urokinase receptor 1.0608
KIF23 kinesin family member 23 1.05972
TRIB3 tribbles pseudokinase 3 1.05936
BUB3 BUB3 mitotic checkpoint protein 1.05936
ISG15 ISG15 ubiquitin-like modifier 1.05936
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.05793
SFN stratifin 1.05685
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 1.05423
SESN1 sestrin 1 1.05386
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.05274
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 1.05163
CST3 cystatin C 1.05163
C3 complement component 3 1.05052
CD14 CD14 molecule 1.04904
TUBB tubulin, beta class I 1.04904
KANK1 KN motif and ankyrin repeat domains 1 1.04794
DDIT4 DNA-damage-inducible transcript 4 1.04611
LMNB1 lamin B1 1.04427
BCL6 B-cell CLL/lymphoma 6 1.04389
ESR1 estrogen receptor 1 1.04276
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.04051
FYN FYN proto-oncogene, Src family tyrosine kinase 1.03939
CAPN2 calpain 2, (m/II) large subunit 1.03678
JCHAIN joining chain of multimeric IgA and IgM 1.03678
RNF19B ring finger protein 19B 1.03641
TMPO thymopoietin 1.03456
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 1.03419
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1.03419
STK17A serine/threonine kinase 17a 1.03197
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 1.03197
SOD1 superoxide dismutase 1, soluble 1.02933
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 1.02708
CCAR1 cell division cycle and apoptosis regulator 1 1.02634
SAT1 spermidine/spermine N1-acetyltransferase 1 1.02485
TYMS thymidylate synthetase 1.0241
NUSAP1 nucleolar and spindle associated protein 1 1.02299
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 1.02188
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 1.02151
MARCKS myristoylated alanine-rich protein kinase C substrate 1.02077
PDK1 pyruvate dehydrogenase kinase, isozyme 1 1.01814
PTP4A1 protein tyrosine phosphatase type IVA, member 1 1.01776
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) 1.01701
DCN decorin 1.01587
ICAM1 intercellular adhesion molecule 1 1.01437
MCM5 minichromosome maintenance complex component 5 1.01361