TERT Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description telomerase reverse transcriptase|Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7015)
External Link http://www.ncbi.nlm.nih.gov/gene/7015
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Genes

82 interacting proteins for TERT from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACAA2 acetyl-CoA acyltransferase 2
ACD adrenocortical dysplasia homolog (mouse)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANXA2 annexin A2
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
C19ORF40 chromosome 19 open reading frame 40
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CIB1 calcium and integrin binding 1 (calmyrin)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DDB1 damage-specific DNA binding protein 1, 127kDa
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DKC1 dyskeratosis congenita 1, dyskerin
DYNLL1 dynein, light chain, LC8-type 1
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ENO1 enolase 1, (alpha)
GLA galactosidase, alpha
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1B heat shock 70kDa protein 1B
HSPA4 heat shock 70kDa protein 4
IFNG interferon, gamma
IL2 interleukin 2
IREB2 iron-responsive element binding protein 2
IRF1 interferon regulatory factor 1
MCRS1 microspherule protein 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MKRN1 makorin ring finger protein 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NAF1 nuclear assembly factor 1 ribonucleoprotein
NAT10 N-acetyltransferase 10 (GCN5-related)
NCL nucleolin
NHP2 NHP2 ribonucleoprotein
NOP10 NOP10 ribonucleoprotein
PABPC1 poly(A) binding protein, cytoplasmic 1
PBK PDZ binding kinase
PFDN1 prefoldin subunit 1
PHF20L1 PHD finger protein 20-like 1
PIF1 PIF1 5'-to-3' DNA helicase
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PML promyelocytic leukemia
POT1 protection of telomeres 1
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRKCA protein kinase C, alpha
PTGES3 prostaglandin E synthase 3 (cytosolic)
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
SERBP1 SERPINE1 mRNA binding protein 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SMG5 SMG5 nonsense mediated mRNA decay factor
SMG6 SMG6 nonsense mediated mRNA decay factor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STEAP4 STEAP family member 4
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TEP1 telomerase-associated protein 1
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM21 translocase of inner mitochondrial membrane 21 homolog (yeast)
TPP1 tripeptidyl peptidase I
TUBA1B tubulin, alpha 1b
U2SURP U2 snRNP-associated SURP domain containing
UBC ubiquitin C
UBD ubiquitin D
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE3A ubiquitin protein ligase E3A
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
VPRBP Vpr (HIV-1) binding protein
WRAP53 WD repeat containing, antisense to TP53
XPO1 exportin 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta