Substance-Related Disorders Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

199 genes associated with the Substance-Related Disorders phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ADCY7 adenylate cyclase 7
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADH6 alcohol dehydrogenase 6 (class V)
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ADORA2A adenosine A2a receptor
ADRA1A adrenoceptor alpha 1A
ADRA2A adrenoceptor alpha 2A
ADRA2B adrenoceptor alpha 2B
ADRA2C adrenoceptor alpha 2C
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANKK1 ankyrin repeat and kinase domain containing 1
AR androgen receptor
ARRB2 arrestin, beta 2
AVP arginine vasopressin
AVPR1A arginine vasopressin receptor 1A
AVPR1B arginine vasopressin receptor 1B
BAIAP3 BAI1-associated protein 3
BDNF brain-derived neurotrophic factor
CARTPT CART prepropeptide
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CCK cholecystokinin
CCKAR cholecystokinin A receptor
CCKBR cholecystokinin B receptor
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CCL5 chemokine (C-C motif) ligand 5
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CDH13 cadherin 13
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CHRM1 cholinergic receptor, muscarinic 1
CHRM2 cholinergic receptor, muscarinic 2
CHRM3 cholinergic receptor, muscarinic 3
CHRM4 cholinergic receptor, muscarinic 4
CHRM5 cholinergic receptor, muscarinic 5
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CLOCK clock circadian regulator
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
CNTNAP2 contactin associated protein-like 2
COL25A1 collagen, type XXV, alpha 1
COMT catechol-O-methyltransferase
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CRH corticotropin releasing hormone
CRHBP corticotropin releasing hormone binding protein
CRHR1 corticotropin releasing hormone receptor 1
CRHR2 corticotropin releasing hormone receptor 2
CSNK1E casein kinase 1, epsilon
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DRD5 dopamine receptor D5
DTNBP1 dystrobrevin binding protein 1
ESR1 estrogen receptor 1
FAAH fatty acid amide hydrolase
FASLG Fas ligand (TNF superfamily, member 6)
FEV FEV (ETS oncogene family)
FKBP5 FK506 binding protein 5
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GAL galanin/GMAP prepropeptide
GALR1 galanin receptor 1
GHRL ghrelin/obestatin prepropeptide
GLRA1 glycine receptor, alpha 1
GLRA2 glycine receptor, alpha 2
GLRB glycine receptor, beta
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GPHN gephyrin
GPX1 glutathione peroxidase 1
GRIK1 glutamate receptor, ionotropic, kainate 1
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRM1 glutamate receptor, metabotropic 1
GSK3B glycogen synthase kinase 3 beta
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
HCRT hypocretin (orexin) neuropeptide precursor
HFE hemochromatosis
HLA-C major histocompatibility complex, class I, C
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HYKK hydroxylysine kinase
IL10 interleukin 10
JUN jun proto-oncogene
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
LEP leptin
LTA lymphotoxin alpha
MANEA mannosidase, endo-alpha
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MIR182 microRNA 182
MIR183 microRNA 183
MIR96 microRNA 96
MPDZ multiple PDZ domain protein
MPO myeloperoxidase
NCAM1 neural cell adhesion molecule 1
NGF nerve growth factor (beta polypeptide)
NOD2 nucleotide-binding oligomerization domain containing 2
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NPY2R neuropeptide Y receptor Y2
NPY5R neuropeptide Y receptor Y5
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C2 nuclear receptor subfamily 3, group C, member 2
NRXN3 neurexin 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTSR1 neurotensin receptor 1 (high affinity)
NTSR2 neurotensin receptor 2
OPRD1 opioid receptor, delta 1
OPRK1 opioid receptor, kappa 1
OPRL1 opiate receptor-like 1
OPRM1 opioid receptor, mu 1
OXT oxytocin/neurophysin I prepropeptide
OXTR oxytocin receptor
PDYN prodynorphin
PENK proenkephalin
PKNOX2 PBX/knotted 1 homeobox 2
PNOC prepronociceptin
POMC proopiomelanocortin
PON1 paraoxonase 1
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PTPRB protein tyrosine phosphatase, receptor type, B
RGS17 regulator of G-protein signaling 17
RGS20 regulator of G-protein signaling 20
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD2 superoxide dismutase 2, mitochondrial
TAC1 tachykinin, precursor 1
TNF tumor necrosis factor
TP53 tumor protein p53
TPH1 tryptophan hydroxylase 1
TPH2 tryptophan hydroxylase 2
TTC12 tetratricopeptide repeat domain 12
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VKORC1 vitamin K epoxide reductase complex, subunit 1
WWC1 WW and C2 domain containing 1