Substance-Related Disorders Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D019966
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Genes

347 genes/proteins associated with the disease Substance-Related Disorders from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
FAM184B family with sequence similarity 184, member B 2.88009
CHD1L chromodomain helicase DNA binding protein 1-like 2.88009
ZNF385D zinc finger protein 385D 2.88009
PBX1 pre-B-cell leukemia homeobox 1 2.88009
SYNE1 spectrin repeat containing, nuclear envelope 1 2.88009
PLA2R1 phospholipase A2 receptor 1, 180kDa 2.88009
CTNNA3 catenin (cadherin-associated protein), alpha 3 2.88009
CERS6 ceramide synthase 6 2.88009
FRMD4A FERM domain containing 4A 2.88009
HSPA12A heat shock 70kDa protein 12A 2.88009
NRXN3 neurexin 3 2.88009
THSD4 thrombospondin, type I, domain containing 4 2.88009
CXCL14 chemokine (C-X-C motif) ligand 14 2.88009
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 2.88009
INSR insulin receptor 2.88009
XKR4 XK, Kell blood group complex subunit-related family, member 4 2.88009
CSMD1 CUB and Sushi multiple domains 1 2.88009
TSSC1 tumor suppressing subtransferable candidate 1 2.88009
PCDH15 protocadherin-related 15 2.88009
FAM184A family with sequence similarity 184, member A 2.88009
INADL InaD-like (Drosophila) 2.88009
ANO4 anoctamin 4 2.88009
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 2.88009
BPIFA2 BPI fold containing family A, member 2 2.88009
TMPRSS7 transmembrane protease, serine 7 2.88009
CSRNP3 cysteine-serine-rich nuclear protein 3 2.88009
PRKCE protein kinase C, epsilon 2.88009
LIMCH1 LIM and calponin homology domains 1 2.88009
FAM126A family with sequence similarity 126, member A 2.88009
DRD2 dopamine receptor D2 2.88009
CDH13 cadherin 13 2.88009
ZNF606 zinc finger protein 606 2.88009
ZNF366 zinc finger protein 366 2.88009
LDOC1L leucine zipper, down-regulated in cancer 1-like 2.88009
XYLT1 xylosyltransferase I 2.88009
MYO6 myosin VI 2.88009
FHIT fragile histidine triad 2.88009
AGBL4 ATP/GTP binding protein-like 4 2.88009
CCDC91 coiled-coil domain containing 91 2.88009
GRM7 glutamate receptor, metabotropic 7 2.88009
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 2.88009
GRM5 glutamate receptor, metabotropic 5 2.88009
POLR1D polymerase (RNA) I polypeptide D, 16kDa 2.88009
GRIK2 glutamate receptor, ionotropic, kainate 2 2.88009
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 2.88009
SLC45A2 solute carrier family 45, member 2 2.88009
DNAH8 dynein, axonemal, heavy chain 8 2.88009
CDCP1 CUB domain containing protein 1 2.88009
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.88009
NPY neuropeptide Y 2.88009
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 2.88009
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 2.88009
ETV6 ets variant 6 2.88009
XPO6 exportin 6 2.88009
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.88009
PRKCH protein kinase C, eta 2.88009
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 2.88009
PRPF4 pre-mRNA processing factor 4 2.88009
QSOX1 quiescin Q6 sulfhydryl oxidase 1 2.88009
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 2.88009
DSCAM Down syndrome cell adhesion molecule 2.88009
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 2.88009
CHRM2 cholinergic receptor, muscarinic 2 2.88009
TENM2 teneurin transmembrane protein 2 2.88009
ZNF804A zinc finger protein 804A 2.88009
C10ORF11 chromosome 10 open reading frame 11 2.88009
MPC1 mitochondrial pyruvate carrier 1 2.88009
NRCAM neuronal cell adhesion molecule 2.88009
RHBDD3 rhomboid domain containing 3 2.88009
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2.88009
PACS1 phosphofurin acidic cluster sorting protein 1 2.88009
FAAH fatty acid amide hydrolase 2.88009
C5ORF63 chromosome 5 open reading frame 63 2.88009
CNR1 cannabinoid receptor 1 (brain) 2.88009
DOCK1 dedicator of cytokinesis 1 2.88009
MYO5C myosin VC 2.88009
GRIA4 glutamate receptor, ionotropic, AMPA 4 2.88009
OPRD1 opioid receptor, delta 1 2.88009
AFF3 AF4/FMR2 family, member 3 2.88009
SAMD4A sterile alpha motif domain containing 4A 2.88009
COLEC12 collectin sub-family member 12 2.88009
SLK STE20-like kinase 2.88009
WDR11 WD repeat domain 11 2.88009
LDLRAD3 low density lipoprotein receptor class A domain containing 3 2.88009
ABLIM1 actin binding LIM protein 1 2.88009
AKAP7 A kinase (PRKA) anchor protein 7 2.88009
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.88009
PARVA parvin, alpha 2.88009
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 2.88009
C10ORF82 chromosome 10 open reading frame 82 2.88009
OR51E1 olfactory receptor, family 51, subfamily E, member 1 2.88009
C19ORF18 chromosome 19 open reading frame 18 2.88009
FKBP15 FK506 binding protein 15, 133kDa 2.88009
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 2.88009
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 2.88009
FHOD3 formin homology 2 domain containing 3 2.88009
RAD51B RAD51 paralog B 2.88009
MSRA methionine sulfoxide reductase A 2.88009
MACROD2 MACRO domain containing 2 2.88009
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 2.88009
CSMD3 CUB and Sushi multiple domains 3 2.88009
CD274 CD274 molecule 2.88009
CADPS2 Ca++-dependent secretion activator 2 2.88009
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 2.88009
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.88009
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.88009
KLF12 Kruppel-like factor 12 2.88009
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 2.88009
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.88009
TIAM2 T-cell lymphoma invasion and metastasis 2 2.88009
BCAR3 breast cancer anti-estrogen resistance 3 2.88009
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.88009
NME7 NME/NM23 family member 7 2.88009
TTC21B tetratricopeptide repeat domain 21B 2.88009
FOS FBJ murine osteosarcoma viral oncogene homolog 2.28676
BDNF brain-derived neurotrophic factor 2.24464
DRD1 dopamine receptor D1 2.13676
OPRM1 opioid receptor, mu 1 2.09369
CREB1 cAMP responsive element binding protein 1 2.05991
PRL prolactin 2.008
DRD3 dopamine receptor D3 1.99552
TH tyrosine hydroxylase 1.98697
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.96566
GFAP glial fibrillary acidic protein 1.9296
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.92721
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.92218
PENK proenkephalin 1.92218
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.89471
OPRK1 opioid receptor, kappa 1 1.88458
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 1.85764
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.84587
JUNB jun B proto-oncogene 1.81629
MAPK1 mitogen-activated protein kinase 1 1.81299
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.80605
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.76559
CRH corticotropin releasing hormone 1.76309
EGR1 early growth response 1 1.74159
MAPK3 mitogen-activated protein kinase 3 1.74139
POMC proopiomelanocortin 1.73999
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.70719
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 1.70368
JUN jun proto-oncogene 1.68106
ADORA2A adenosine A2a receptor 1.6482
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.63832
TNF tumor necrosis factor 1.63116
TAC1 tachykinin, precursor 1 1.62468
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.60314
PDYN prodynorphin 1.59943
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.57829
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.57498
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.56141
IL2 interleukin 2 1.53941
HOMER1 homer scaffolding protein 1 1.52464
CAT catalase 1.51936
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.51105
MAOA monoamine oxidase A 1.50248
BAX BCL2-associated X protein 1.50248
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.49533
CAMK4 calcium/calmodulin-dependent protein kinase IV 1.48119
NTNG1 netrin G1 1.48042
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.47582
GRM1 glutamate receptor, metabotropic 1 1.47582
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.47504
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 1.4727
DRD4 dopamine receptor D4 1.47064
MAOB monoamine oxidase B 1.47038
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.46754
ELK1 ELK1, member of ETS oncogene family 1.45962
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 1.45564
ARC activity-regulated cytoskeleton-associated protein 1.44763
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 1.44735
GSK3B glycogen synthase kinase 3 beta 1.44544
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 1.44219
FOSL2 FOS-like antigen 2 1.43184
GSK3A glycogen synthase kinase 3 alpha 1.40953
DLG4 discs, large homolog 4 (Drosophila) 1.39952
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 1.39952
CDK5 cyclin-dependent kinase 5 1.39785
MAPK8 mitogen-activated protein kinase 8 1.38807
MAP2K1 mitogen-activated protein kinase kinase 1 1.3827
IFNG interferon, gamma 1.381
PVALB parvalbumin 1.37504
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.3716
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.36076
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.35934
MAP2K2 mitogen-activated protein kinase kinase 2 1.35299
APP amyloid beta (A4) precursor protein 1.35155
GAL galanin/GMAP prepropeptide 1.35127
HPCA hippocalcin 1.33909
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.3385
CCK cholecystokinin 1.33553
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 1.33523
FAS Fas cell surface death receptor 1.33405
PLCD4 phospholipase C, delta 4 1.32964
TMEM125 transmembrane protein 125 1.32428
DUSP1 dual specificity phosphatase 1 1.32428
GDNF glial cell derived neurotrophic factor 1.32399
COMT catechol-O-methyltransferase 1.31746
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.31686
NUPR1 nuclear protein, transcriptional regulator, 1 1.31178
GRIA3 glutamate receptor, ionotropic, AMPA 3 1.30941
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 1.30788
CX3CL1 chemokine (C-X3-C motif) ligand 1 1.30543
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 1.30482
CES2 carboxylesterase 2 1.30238
SREBF2 sterol regulatory element binding transcription factor 2 1.29996
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.29688
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.29256
TRH thyrotropin-releasing hormone 1.28641
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 1.27689
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.27378
SHOX2 short stature homeobox 2 1.27101
IL4 interleukin 4 1.26514
DUSP6 dual specificity phosphatase 6 1.26021
VEGFA vascular endothelial growth factor A 1.24905
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.23962
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 1.23899
BCL2 B-cell CLL/lymphoma 2 1.23868
MAP2 microtubule-associated protein 2 1.23648
NTS neurotensin 1.23648
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.23074
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 1.22501
PLP1 proteolipid protein 1 1.22501
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.22112
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.2208
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 1.21791
GPR88 G protein-coupled receptor 88 1.21631
AVP arginine vasopressin 1.21337
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.21173
ADORA1 adenosine A1 receptor 1.21043
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.20946
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 1.20493
NOS2 nitric oxide synthase 2, inducible 1.20427
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1.20229
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.20031
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.19999
JUND jun D proto-oncogene 1.19868
IL6 interleukin 6 1.19639
ADCY5 adenylate cyclase 5 1.19179
EFHD1 EF-hand domain family, member D1 1.19179
LMO7 LIM domain 7 1.19179
RELN reelin 1.1908
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.18521
SOD1 superoxide dismutase 1, soluble 1.18424
RGS2 regulator of G-protein signaling 2 1.18159
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 1.17893
ARPP21 cAMP-regulated phosphoprotein, 21kDa 1.17827
PRKCB protein kinase C, beta 1.17596
CTSD cathepsin D 1.17333
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 1.17268
GSTP1 glutathione S-transferase pi 1 1.17235
FGF2 fibroblast growth factor 2 (basic) 1.16766
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.16666
MAPK14 mitogen-activated protein kinase 14 1.16533
SYT9 synaptotagmin IX 1.165
EGR3 early growth response 3 1.16401
PRKCD protein kinase C, delta 1.16001
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 1.15729
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 1.15122
GRIK5 glutamate receptor, ionotropic, kainate 5 1.14473
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 1.14473
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 1.14473
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.14404
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.13997
FXYD7 FXYD domain containing ion transport regulator 7 1.13895
CBLN1 cerebellin 1 precursor 1.13895
IL1B interleukin 1, beta 1.13758
PDE10A phosphodiesterase 10A 1.13655
UBC ubiquitin C 1.13075
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.12838
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 1.12838
CCT2 chaperonin containing TCP1, subunit 2 (beta) 1.12805
MBP myelin basic protein 1.1253
OXT oxytocin/neurophysin I prepropeptide 1.12219
RGS9 regulator of G-protein signaling 9 1.12151
PRKCZ protein kinase C, zeta 1.11911
FYN FYN proto-oncogene, Src family tyrosine kinase 1.11151
BCL2L1 BCL2-like 1 1.10977
LEP leptin 1.10942
MMP13 matrix metallopeptidase 13 1.10872
MAP1B microtubule-associated protein 1B 1.10769
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.10734
ARPP19 cAMP-regulated phosphoprotein, 19kDa 1.10699
NGF nerve growth factor (beta polypeptide) 1.10493
CRTAC1 cartilage acidic protein 1 1.10493
CCKBR cholecystokinin B receptor 1.10282
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.09857
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.09786
CTSB cathepsin B 1.09681
IL10 interleukin 10 1.09576
STXBP1 syntaxin binding protein 1 1.09297
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1.08797
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 1.08797
PLAT plasminogen activator, tissue 1.0869
REM2 RAS (RAD and GEM)-like GTP binding 2 1.08231
G6PC3 glucose 6 phosphatase, catalytic, 3 1.08231
PARP1 poly (ADP-ribose) polymerase 1 1.08055
GAP43 growth associated protein 43 1.07518
XDH xanthine dehydrogenase 1.0734
LIN7C lin-7 homolog C (C. elegans) 1.07199
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 1.07199
FOSL1 FOS-like antigen 1 1.06917
PRR18 proline rich 18 1.06734
NSF N-ethylmaleimide-sensitive factor 1.06661
TPI1 triosephosphate isomerase 1 1.06479
EYA2 EYA transcriptional coactivator and phosphatase 2 1.06225
SERTAD4 SERTA domain containing 4 1.06225
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.06225
PRRC2A proline-rich coiled-coil 2A 1.06225
SREBF1 sterol regulatory element binding transcription factor 1 1.06188
PHB prohibitin 1.06152
CCL2 chemokine (C-C motif) ligand 2 1.06008
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.05423
RYR3 ryanodine receptor 3 1.05312
SYT4 synaptotagmin IV 1.05274
ANO3 anoctamin 3 1.05274
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.05089
INS insulin 1.04941
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 1.04794
NEFH neurofilament, heavy polypeptide 1.04465
GRM3 glutamate receptor, metabotropic 3 1.04352
ADCY8 adenylate cyclase 8 (brain) 1.04352
HDAC3 histone deacetylase 3 1.04201
CARTPT CART prepropeptide 1.04201
GH1 growth hormone 1 1.04088
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.04088
NOS1 nitric oxide synthase 1 (neuronal) 1.04051
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 1.03604
MAP2K5 mitogen-activated protein kinase kinase 5 1.03604
PRKCG protein kinase C, gamma 1.03009
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 1.03009
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.02971
AP2B1 adaptor-related protein complex 2, beta 1 subunit 1.02596
MAP1A microtubule-associated protein 1A 1.02559
LHB luteinizing hormone beta polypeptide 1.02336
CCND1 cyclin D1 1.02188
LDLR low density lipoprotein receptor 1.02151
KCNIP3 Kv channel interacting protein 3, calsenilin 1.02003
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 1.01739
PRKCA protein kinase C, alpha 1.01512
CALCA calcitonin-related polypeptide alpha 1.01512
CTSK cathepsin K 1.01399
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.01399
INHA inhibin, alpha 1.01324
HIGD1A HIG1 hypoxia inducible domain family, member 1A 1.01324
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.01286
TP53 tumor protein p53 1.01174