Spondylitis, Ankylosing Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

185 genes associated with the Spondylitis, Ankylosing phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1
ACE angiotensin I converting enzyme
ADA adenosine deaminase
ADRB1 adrenoceptor beta 1
ALPL alkaline phosphatase, liver/bone/kidney
ANKH ANKH inorganic pyrophosphate transport regulator
ANO6 anoctamin 6
ANTXR2 anthrax toxin receptor 2
AR androgen receptor
ASPN asporin
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BMP8A bone morphogenetic protein 8a
BTNL2 butyrophilin-like 2
C11ORF30 chromosome 11 open reading frame 30
C1ORF106 chromosome 1 open reading frame 106
C4A complement component 4A (Rodgers blood group)
C4B complement component 4B (Chido blood group)
CARD8 caspase recruitment domain family, member 8
CARD9 caspase recruitment domain family, member 9
CCL2 chemokine (C-C motif) ligand 2
CCL7 chemokine (C-C motif) ligand 7
CCR6 chemokine (C-C motif) receptor 6
CD14 CD14 molecule
CD274 CD274 molecule
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CNOT3 CCR4-NOT transcription complex, subunit 3
CNTN5 contactin 5
COL6A1 collagen, type VI, alpha 1
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DBP D site of albumin promoter (albumin D-box) binding protein
EDIL3 EGF-like repeats and discoidin I-like domains 3
EEF1DP3 eukaryotic translation elongation factor 1 delta pseudogene 3
ERAP1 endoplasmic reticulum aminopeptidase 1
ERAP2 endoplasmic reticulum aminopeptidase 2
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCRL3 Fc receptor-like 3
FCRL4 Fc receptor-like 4
FCRL5 Fc receptor-like 5
FOXO1 forkhead box O1
GC group-specific component (vitamin D binding protein)
GCKR glucokinase (hexokinase 4) regulator
GNL1 guanine nucleotide binding protein-like 1
GSDMB gasdermin B
HAPLN1 hyaluronan and proteoglycan link protein 1
HAVCR2 hepatitis A virus cellular receptor 2
HHAT hedgehog acyltransferase
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HLA-E major histocompatibility complex, class I, E
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
ICOSLG inducible T-cell co-stimulator ligand
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10 interleukin 10
IL12B interleukin 12B
IL17RA interleukin 17 receptor A
IL18RAP interleukin 18 receptor accessory protein
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1F10 interleukin 1 family, member 10 (theta)
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
IL23R interleukin 23 receptor
IL2RA interleukin 2 receptor, alpha
IL33 interleukin 33
IL36A interleukin 36, alpha
IL36B interleukin 36, beta
IL36G interleukin 36, gamma
IL36RN interleukin 36 receptor antagonist
IL37 interleukin 37
IL4 interleukin 4
IL6 interleukin 6
IRGM immunity-related GTPase family, M
ITLN1 intelectin 1 (galactofuranose binding)
JAK2 Janus kinase 2
JMY junction mediating and regulatory protein, p53 cofactor
KDM5A lysine (K)-specific demethylase 5A
KIF21B kinesin family member 21B
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KIR2DL5B killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5B
KIR2DP1 killer cell immunoglobulin-like receptor, two domains, pseudogene 1
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
KIR2DS3 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KIR2DS5 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
KIR3DP1 killer cell immunoglobulin-like receptor, three domains, pseudogene 1
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LRP5 low density lipoprotein receptor-related protein 5
LRRK2 leucine-rich repeat kinase 2
LTA lymphotoxin alpha
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LYRM4 LYR motif containing 4
MBL2 mannose-binding lectin (protein C) 2, soluble
MEFV Mediterranean fever
MICA MHC class I polypeptide-related sequence A
MIR182 microRNA 182
MIR196A2 microRNA 196a-2
MIR27A microRNA 27a
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MROH3P maestro heat-like repeat family member 3, pseudogene
MST1 macrophage stimulating 1
MSX2 msh homeobox 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC19 mucin 19, oligomeric
NELL1 NEL-like 1 (chicken)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX2-3 NK2 homeobox 3
NLRP1 NLR family, pyrin domain containing 1
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
NOS3 nitric oxide synthase 3 (endothelial cell)
ORAI1 ORAI calcium release-activated calcium modulator 1
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3
PADI4 peptidyl arginine deiminase, type IV
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
PRR3 proline rich 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PUS10 pseudouridylate synthase 10
RGS6 regulator of G-protein signaling 6
RUNX3 runt-related transcription factor 3
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC22A23 solute carrier family 22, member 23
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SOD2 superoxide dismutase 2, mitochondrial
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBKBP1 TBK1 binding protein 1
TGFB1 transforming growth factor, beta 1
TIMP1 TIMP metallopeptidase inhibitor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TNAP TRAFs and NIK-associated protein
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRADD TNFRSF1A-associated via death domain
TRAF5 TNF receptor-associated factor 5
TSHR thyroid stimulating hormone receptor
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum)
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VIPR1 vasoactive intestinal peptide receptor 1
ZNF365 zinc finger protein 365
ZPBP2 zona pellucida binding protein 2