Splenic Diseases Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D013158
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Genes

265 genes/proteins associated with the disease Splenic Diseases from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
TLX1 T-cell leukemia homeobox 1 2.88009
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 2.88009
AHR aryl hydrocarbon receptor 2.88009
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.60407
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 1.59521
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.59218
IGFBP3 insulin-like growth factor binding protein 3 1.4591
KDR kinase insert domain receptor 1.45803
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 1.45537
CCNB1 cyclin B1 1.44626
RHOB ras homolog family member B 1.43048
IL2RB interleukin 2 receptor, beta 1.42589
MAPK3 mitogen-activated protein kinase 3 1.42428
MAPK1 mitogen-activated protein kinase 1 1.41667
IL6 interleukin 6 1.41368
ADIPOQ adiponectin, C1Q and collagen domain containing 1.41285
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 1.39422
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.39338
BAX BCL2-associated X protein 1.39086
FN1 fibronectin 1 1.3736
LEF1 lymphoid enhancer-binding factor 1 1.36648
CISH cytokine inducible SH2-containing protein 1.3639
CDK1 cyclin-dependent kinase 1 1.35589
PGC progastricsin (pepsinogen C) 1.34752
RRM1 ribonucleotide reductase M1 1.34372
CA8 carbonic anhydrase VIII 1.34227
CCL2 chemokine (C-C motif) ligand 2 1.33316
CXCL12 chemokine (C-X-C motif) ligand 12 1.33169
RASSF4 Ras association (RalGDS/AF-6) domain family member 4 1.3085
HMGB2 high mobility group box 2 1.29011
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.29011
AR androgen receptor 1.28919
TOP2A topoisomerase (DNA) II alpha 170kDa 1.28827
ORM1 orosomucoid 1 1.28796
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 1.28303
MCM2 minichromosome maintenance complex component 2 1.28058
EEF2 eukaryotic translation elongation factor 2 1.27502
INHBA inhibin, beta A 1.27162
PLCB4 phospholipase C, beta 4 1.27162
PRIM2 primase, DNA, polypeptide 2 (58kDa) 1.27162
AQP3 aquaporin 3 (Gill blood group) 1.26607
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.26514
SGMS1 sphingomyelin synthase 1 1.25369
CCNE1 cyclin E1 1.24966
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 1.2475
SPON1 spondin 1, extracellular matrix protein 1.24718
EGF epidermal growth factor 1.2437
CCNA2 cyclin A2 1.24181
LRRC26 leucine rich repeat containing 26 1.2415
NR1I3 nuclear receptor subfamily 1, group I, member 3 1.23837
CDC20 cell division cycle 20 1.23488
CLEC5A C-type lectin domain family 5, member A 1.23296
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 1.22534
SCGB3A2 secretoglobin, family 3A, member 2 1.22501
FOXP1 forkhead box P1 1.22501
TXNIP thioredoxin interacting protein 1.21823
CD6 CD6 molecule 1.21695
CES3 carboxylesterase 3 1.21663
MYLK2 myosin light chain kinase 2 1.20946
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 1.20558
TRIP13 thyroid hormone receptor interactor 13 1.20493
TTR transthyretin 1.19868
CCND2 cyclin D2 1.19737
S100A11 S100 calcium binding protein A11 1.19672
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.19574
NFIB nuclear factor I/B 1.19412
DOCK7 dedicator of cytokinesis 7 1.18882
TEX30 testis expressed 30 1.18882
HLA-DMB major histocompatibility complex, class II, DM beta 1.18849
C3 complement component 3 1.18652
GADD45A growth arrest and DNA-damage-inducible, alpha 1.18193
FABP4 fatty acid binding protein 4, adipocyte 1.18159
MGST3 microsomal glutathione S-transferase 3 1.17893
CCNA1 cyclin A1 1.17893
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.17728
GPR88 G protein-coupled receptor 88 1.17662
CD1D CD1d molecule 1.17596
ALB albumin 1.17101
SCN4B sodium channel, voltage gated, type IV beta subunit 1.17034
CIB2 calcium and integrin binding family member 2 1.17
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 1.167
VCAM1 vascular cell adhesion molecule 1 1.16633
DGAT2 diacylglycerol O-acyltransferase 2 1.16467
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 1.16236
CDON cell adhesion associated, oncogene regulated 1.15899
RAG1 recombination activating gene 1 1.15899
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 1.15865
TGFB1 transforming growth factor, beta 1 1.15831
KLF5 Kruppel-like factor 5 (intestinal) 1.15593
DTNB dystrobrevin, beta 1.15324
LDB3 LIM domain binding 3 1.15324
CPA2 carboxypeptidase A2 (pancreatic) 1.15324
PCNA proliferating cell nuclear antigen 1.15122
PAPL iron/zinc purple acid phosphatase-like protein 1.1485
PDE7B phosphodiesterase 7B 1.14816
CRLF1 cytokine receptor-like factor 1 1.14816
PTK2B protein tyrosine kinase 2 beta 1.14678
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 1.14507
SOCS2 suppressor of cytokine signaling 2 1.14473
YPEL1 yippee-like 1 (Drosophila) 1.14302
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 1.14268
AGTR1 angiotensin II receptor, type 1 1.14064
MKI67 marker of proliferation Ki-67 1.13997
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 1.13793
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.13758
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 1.13449
ENO2 enolase 2 (gamma, neuronal) 1.13279
RGS8 regulator of G-protein signaling 8 1.13279
MCM5 minichromosome maintenance complex component 5 1.13245
KRTAP19-4 keratin associated protein 19-4 1.1294
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 1.12906
RPS16 ribosomal protein S16 1.12838
SIRPB1 signal-regulatory protein beta 1 1.12838
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 1.12805
IGF1 insulin-like growth factor 1 (somatomedin C) 1.12703
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 1.12357
NPTX1 neuronal pentraxin I 1.12357
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 1.12185
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 1.11945
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial 1.11466
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 1.11431
SEPP1 selenoprotein P, plasma, 1 1.11325
PDZD9 PDZ domain containing 9 1.1122
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.11186
ZCCHC13 zinc finger, CCHC domain containing 13 1.11116
CCDC74A coiled-coil domain containing 74A 1.11116
CCDC129 coiled-coil domain containing 129 1.11116
MLIP muscular LMNA-interacting protein 1.11116
KIFC1 kinesin family member C1 1.11116
CHN2 chimerin 2 1.11046
ANK1 ankyrin 1, erythrocytic 1.10977
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.10942
DHCR7 7-dehydrocholesterol reductase 1.10631
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 1.10631
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 1.10596
DACT2 dishevelled-binding antagonist of beta-catenin 2 1.10596
CKAP4 cytoskeleton-associated protein 4 1.10562
BCL2 B-cell CLL/lymphoma 2 1.10527
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.10246
LPL lipoprotein lipase 1.10211
CTNND1 catenin (cadherin-associated protein), delta 1 1.10175
A2M alpha-2-macroglobulin 1.1014
MCF2L MCF.2 cell line derived transforming sequence-like 1.1014
POR P450 (cytochrome) oxidoreductase 1.09857
TSC22D1 TSC22 domain family, member 1 1.09751
STIL SCL/TAL1 interrupting locus 1.09751
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.09716
PTTG1 pituitary tumor-transforming 1 1.09716
FMO1 flavin containing monooxygenase 1 1.09716
MRGPRX2 MAS-related GPR, member X2 1.09681
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.09646
DEFB114 defensin, beta 114 1.09576
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 1.09576
F2R coagulation factor II (thrombin) receptor 1.09541
RBMS1 RNA binding motif, single stranded interacting protein 1 1.09401
AQP1 aquaporin 1 (Colton blood group) 1.09366
KNTC1 kinetochore associated 1 1.09366
MOGAT1 monoacylglycerol O-acyltransferase 1 1.09332
NR4A2 nuclear receptor subfamily 4, group A, member 2 1.0919
ITSN1 intersectin 1 (SH3 domain protein) 1.08975
TPM1 tropomyosin 1 (alpha) 1.08868
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) 1.08619
SQLE squalene epoxidase 1.08549
IRF1 interferon regulatory factor 1 1.08372
GADL1 glutamate decarboxylase-like 1 1.08196
ITGAD integrin, alpha D 1.08196
SAA2 serum amyloid A2 1.08196
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.08091
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 1.07911
C8B complement component 8, beta polypeptide 1.07804
AZGP1 alpha-2-glycoprotein 1, zinc-binding 1.07804
CDK2 cyclin-dependent kinase 2 1.07732
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 1.07553
IL17RB interleukin 17 receptor B 1.07518
LIN7A lin-7 homolog A (C. elegans) 1.07163
SGOL1 shugoshin-like 1 (S. pombe) 1.07093
FGF1 fibroblast growth factor 1 (acidic) 1.06952
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 1.06808
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 1.06808
SOD1 superoxide dismutase 1, soluble 1.06771
FIGNL1 fidgetin-like 1 1.06771
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 1.06734
GLUL glutamate-ammonia ligase 1.06625
RAD51 RAD51 recombinase 1.06479
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 1.06442
SOX11 SRY (sex determining region Y)-box 11 1.06406
IL10 interleukin 10 1.06225
FIGF c-fos induced growth factor (vascular endothelial growth factor D) 1.0608
SLCO4A1 solute carrier organic anion transporter family, member 4A1 1.06044
WASF3 WAS protein family, member 3 1.05828
GGACT gamma-glutamylamine cyclotransferase 1.05828
FAM43B family with sequence similarity 43, member B 1.05828
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.05793
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 1.05757
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 1.05721
GNG13 guanine nucleotide binding protein (G protein), gamma 13 1.05721
MBL2 mannose-binding lectin (protein C) 2, soluble 1.05423
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) 1.05423
CCNG1 cyclin G1 1.05349
ANKRD12 ankyrin repeat domain 12 1.05089
ACSL1 acyl-CoA synthetase long-chain family member 1 1.05015
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.04831
RRM2 ribonucleotide reductase M2 1.04684
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.04611
DEPDC1 DEP domain containing 1 1.04611
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.04465
FANCD2 Fanconi anemia, complementation group D2 1.04427
CCNB2 cyclin B2 1.04389
TP53 tumor protein p53 1.04051
COL3A1 collagen, type III, alpha 1 1.04014
SPP1 secreted phosphoprotein 1 1.03976
IL1RN interleukin 1 receptor antagonist 1.03827
CDCA5 cell division cycle associated 5 1.03789
MANBAL mannosidase, beta A, lysosomal-like 1.03678
ASB16 ankyrin repeat and SOCS box containing 16 1.03641
EFCAB11 EF-hand calcium binding domain 11 1.03641
ZIC4 Zic family member 4 1.03604
RMRP RNA component of mitochondrial RNA processing endoribonuclease 1.03567
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 1.03567
CSRP2 cysteine and glycine-rich protein 2 1.0353
ASPH aspartate beta-hydroxylase 1.03493
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) 1.03493
PDE4DIP phosphodiesterase 4D interacting protein 1.03235
TNF tumor necrosis factor 1.03159
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 1.02933
CRYAB crystallin, alpha B 1.02896
PCDH11X protocadherin 11 X-linked 1.02708
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 1.02708
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 1.02634
FAT2 FAT atypical cadherin 2 1.02634
LMBRD2 LMBR1 domain containing 2 1.02634
MYO1B myosin IB 1.02596
ZMYND15 zinc finger, MYND-type containing 15 1.02596
USP44 ubiquitin specific peptidase 44 1.02596
SFRP1 secreted frizzled-related protein 1 1.02596
AGBL2 ATP/GTP binding protein-like 2 1.02596
TCHP trichoplein, keratin filament binding 1.02596
SCARF1 scavenger receptor class F, member 1 1.02596
TFF3 trefoil factor 3 (intestinal) 1.02447
IL7 interleukin 7 1.0241
BARD1 BRCA1 associated RING domain 1 1.02373
FKBP1A FK506 binding protein 1A, 12kDa 1.02373
CDCA2 cell division cycle associated 2 1.02336
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 1.02336
PRIM1 primase, DNA, polypeptide 1 (49kDa) 1.0204
NUF2 NUF2, NDC80 kinetochore complex component 1.0204
MSR1 macrophage scavenger receptor 1 1.0204
CSRP1 cysteine and glycine-rich protein 1 1.0204
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 1.01776
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 1.01776
HNF1A HNF1 homeobox A 1.01776
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.01739
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X 1.01739
TTLL5 tubulin tyrosine ligase-like family member 5 1.01701
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma 1.01663
EBF2 early B-cell factor 2 1.01663
SNTG1 syntrophin, gamma 1 1.01663
TMEM255A transmembrane protein 255A 1.01663
SYT10 synaptotagmin X 1.01663
KNDC1 kinase non-catalytic C-lobe domain (KIND) containing 1 1.01663
PVR poliovirus receptor 1.01512
CIDEA cell death-inducing DFFA-like effector a 1.01512
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 1.01249
HAS2 hyaluronan synthase 2 1.01212
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 1.01025