Sphingolipid metabolism Gene Set

Dataset Reactome Pathways
Category structural or functional annotations
Type pathway
Description The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). (Gene Ontology, GO_0006665)
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-428157
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Genes

70 proteins participating in the Sphingolipid metabolism pathway from the Reactome Pathways dataset.

Symbol Name
ACER1 alkaline ceramidase 1
ACER2 alkaline ceramidase 2
ACER3 alkaline ceramidase 3
ARSA arylsulfatase A
ARSB arylsulfatase B
ARSD arylsulfatase D
ARSE arylsulfatase E (chondrodysplasia punctata 1)
ARSF arylsulfatase F
ARSG arylsulfatase G
ARSH arylsulfatase family, member H
ARSI arylsulfatase family, member I
ARSJ arylsulfatase family, member J
ARSK arylsulfatase family, member K
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
CERK ceramide kinase
CERS1 ceramide synthase 1
CERS2 ceramide synthase 2
CERS3 ceramide synthase 3
CERS4 ceramide synthase 4
CERS5 ceramide synthase 5
CERS6 ceramide synthase 6
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CSNK1G2 casein kinase 1, gamma 2
CTSA cathepsin A
DEGS1 delta(4)-desaturase, sphingolipid 1
DEGS2 delta(4)-desaturase, sphingolipid 2
ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7
GALC galactosylceramidase
GBA glucosidase, beta, acid
GBA2 glucosidase, beta (bile acid) 2
GBA3 glucosidase, beta, acid 3 (gene/pseudogene)
GLA galactosidase, alpha
GLB1 galactosidase, beta 1
GLB1L galactosidase, beta 1-like
GM2A GM2 ganglioside activator
HEXA hexosaminidase A (alpha polypeptide)
HEXB hexosaminidase B (beta polypeptide)
KDSR 3-ketodihydrosphingosine reductase
NEU1 sialidase 1 (lysosomal sialidase)
NEU2 sialidase 2 (cytosolic sialidase)
NEU3 sialidase 3 (membrane sialidase)
NEU4 sialidase 4
OSBP oxysterol binding protein
PPAP2A phosphatidic acid phosphatase type 2A
PPAP2B phosphatidic acid phosphatase type 2B
PPAP2C phosphatidic acid phosphatase type 2C
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L
PRKD1 protein kinase D1
PSAP prosaposin
SGMS1 sphingomyelin synthase 1
SGMS2 sphingomyelin synthase 2
SGPL1 sphingosine-1-phosphate lyase 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SGPP2 sphingosine-1-phosphate phosphatase 2
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
SPHK1 sphingosine kinase 1
SPHK2 sphingosine kinase 2
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STS steroid sulfatase (microsomal), isozyme S
SUMF1 sulfatase modifying factor 1
SUMF2 sulfatase modifying factor 2
UGCG UDP-glucose ceramide glucosyltransferase
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C