Speech Disorders Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D013064
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Genes

146 genes/proteins associated with the disease Speech Disorders from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.88009
TTPA tocopherol (alpha) transfer protein 2.88009
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.11009
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.9495
DRD2 dopamine receptor D2 1.93338
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.81921
BAX BCL2-associated X protein 1.81186
PRL prolactin 1.7811
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.77374
CAT catalase 1.75142
FOS FBJ murine osteosarcoma viral oncogene homolog 1.74681
DRD1 dopamine receptor D1 1.7426
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.72696
IL6 interleukin 6 1.70615
TNF tumor necrosis factor 1.6621
JUN jun proto-oncogene 1.65204
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.64865
MAPK1 mitogen-activated protein kinase 1 1.63721
BCL2 B-cell CLL/lymphoma 2 1.61598
HMOX1 heme oxygenase 1 1.6036
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.60035
CXCL8 chemokine (C-X-C motif) ligand 8 1.57641
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.57042
BDNF brain-derived neurotrophic factor 1.56828
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.55304
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.54596
GSK3B glycogen synthase kinase 3 beta 1.54548
NPY neuropeptide Y 1.53382
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.52338
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.52262
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.51657
NOS2 nitric oxide synthase 2, inducible 1.50675
GRIA3 glutamate receptor, ionotropic, AMPA 3 1.48761
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 1.45962
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.4098
MAPK3 mitogen-activated protein kinase 3 1.40623
TH tyrosine hydroxylase 1.40092
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.39591
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.39086
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.38213
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.38071
SOD2 superoxide dismutase 2, mitochondrial 1.37189
EGR1 early growth response 1 1.37047
FAS Fas cell surface death receptor 1.36876
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.34869
CREB1 cAMP responsive element binding protein 1 1.34664
RELN reelin 1.34606
POMC proopiomelanocortin 1.3414
TRH thyrotropin-releasing hormone 1.33022
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.32816
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.32162
JUNB jun B proto-oncogene 1.32044
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 1.31626
MAPK8 mitogen-activated protein kinase 8 1.30881
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.29502
DUSP1 dual specificity phosphatase 1 1.28919
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 1.27875
CNR1 cannabinoid receptor 1 (brain) 1.27471
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 1.26825
APP amyloid beta (A4) precursor protein 1.26763
PARP1 poly (ADP-ribose) polymerase 1 1.26638
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 1.24213
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 1.22664
DRD4 dopamine receptor D4 1.22501
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.21791
MBP myelin basic protein 1.21791
TAGLN transgelin 1.2137
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.21076
SREBF2 sterol regulatory element binding transcription factor 2 1.18456
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 1.16633
FABP1 fatty acid binding protein 1, liver 1.16335
GRIK2 glutamate receptor, ionotropic, kainate 2 1.16269
IL1B interleukin 1, beta 1.15425
GSTP1 glutathione S-transferase pi 1 1.15391
RGS4 regulator of G-protein signaling 4 1.15189
TAC1 tachykinin, precursor 1 1.15156
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.14919
TKT transketolase 1.14919
TP53 tumor protein p53 1.14781
POR P450 (cytochrome) oxidoreductase 1.14678
LHB luteinizing hormone beta polypeptide 1.14575
ICAM1 intercellular adhesion molecule 1 1.14507
OPRM1 opioid receptor, mu 1 1.14404
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.13724
IFNG interferon, gamma 1.13518
NUPR1 nuclear protein, transcriptional regulator, 1 1.13415
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.13041
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.12973
INHBE inhibin, beta E 1.12048
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.11571
CX3CL1 chemokine (C-X3-C motif) ligand 1 1.1129
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.11151
EFNB1 ephrin-B1 1.10872
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.10803
CCL2 chemokine (C-C motif) ligand 2 1.10424
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 1.10033
INS insulin 1.09963
GFAP glial fibrillary acidic protein 1.09401
NCAN neurocan 1.09083
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.09011
PDE4B phosphodiesterase 4B, cAMP-specific 1.08975
CKB creatine kinase, brain 1.08975
ADORA2A adenosine A2a receptor 1.08762
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 1.08726
CALM2 calmodulin 2 (phosphorylase kinase, delta) 1.08407
CDK5 cyclin-dependent kinase 5 1.08019
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.07983
HRH1 histamine receptor H1 1.07911
COMT catechol-O-methyltransferase 1.07696
VEGFA vascular endothelial growth factor A 1.06625
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 1.06588
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.06552
CCND1 cyclin D1 1.06044
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.06008
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 1.05972
NR4A2 nuclear receptor subfamily 4, group A, member 2 1.05972
FMO2 flavin containing monooxygenase 2 (non-functional) 1.05793
GRM1 glutamate receptor, metabotropic 1 1.05793
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.05685
EGR2 early growth response 2 1.04978
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.04794
TLR4 toll-like receptor 4 1.04647
C10ORF10 chromosome 10 open reading frame 10 1.04427
GUCY1B3 guanylate cyclase 1, soluble, beta 3 1.04352
CES2 carboxylesterase 2 1.04201
TEX261 testis expressed 261 1.04126
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.04088
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.03901
GRM5 glutamate receptor, metabotropic 5 1.03715
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1.03715
MAL mal, T-cell differentiation protein 1.03715
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 1.03456
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.03382
SREBF1 sterol regulatory element binding transcription factor 1 1.03382
RGS2 regulator of G-protein signaling 2 1.03046
PRKCE protein kinase C, epsilon 1.02858
PENK proenkephalin 1.02671
MAOB monoamine oxidase B 1.02671
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.02522
HOMER1 homer scaffolding protein 1 1.02114
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.01928
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 1.01776
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.01437
HSPB1 heat shock 27kDa protein 1 1.01361
ADCY8 adenylate cyclase 8 (brain) 1.01361
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.01062