Smooth Muscle Contraction Gene Set

Dataset Reactome Pathways
Category structural or functional annotations
Type pathway
Description A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. (Gene Ontology, GO_0006939)
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-445355
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Genes

22 proteins participating in the Smooth Muscle Contraction pathway from the Reactome Pathways dataset.

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
ITGA1 integrin, alpha 1
ITGB5 integrin, beta 5
LMOD1 leiomodin 1 (smooth muscle)
MYH11 myosin, heavy chain 11, smooth muscle
MYL12B myosin, light chain 12B, regulatory
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
PXN paxillin
SORBS1 sorbin and SH3 domain containing 1
SORBS3 sorbin and SH3 domain containing 3
TLN1 talin 1
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPM3 tropomyosin 3
TPM4 tropomyosin 4
VCL vinculin