Skin Ulcer Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A discontinuity of the skin exhibiting complete loss of the epidermis and often portions of the dermis and even subcutaneous fat. (Human Phenotype Ontology, HP_0200042)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D012883
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Genes

131 genes/proteins associated with the disease Skin Ulcer from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
LAMA3 laminin, alpha 3 2.88009
NGF nerve growth factor (beta polypeptide) 2.88009
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.88009
PEPD peptidase D 2.88009
S100A9 S100 calcium binding protein A9 1.48916
EGR1 early growth response 1 1.45643
CCL2 chemokine (C-C motif) ligand 2 1.45247
MPO myeloperoxidase 1.43892
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.43618
MAP4 microtubule-associated protein 4 1.40401
IL6 interleukin 6 1.39479
BAX BCL2-associated X protein 1.38752
GRPEL1 GrpE-like 1, mitochondrial (E. coli) 1.36961
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.35589
MMP9 matrix metallopeptidase 9 1.33434
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.33257
S100A8 S100 calcium binding protein A8 1.32905
CCNG1 cyclin G1 1.31596
FGF9 fibroblast growth factor 9 1.31566
MMP2 matrix metallopeptidase 2 1.2944
E2F1 E2F transcription factor 1 1.28364
BTG2 BTG family, member 2 1.27936
NOS2 nitric oxide synthase 2, inducible 1.27813
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.27162
ACO1 aconitase 1, soluble 1.25929
SCN1A sodium channel, voltage gated, type I alpha subunit 1.25682
CD38 CD38 molecule 1.25059
GADD45A growth arrest and DNA-damage-inducible, alpha 1.24338
MYL1 myosin, light chain 1, alkali; skeletal, fast 1.24307
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.24087
KIF20A kinesin family member 20A 1.23993
FOS FBJ murine osteosarcoma viral oncogene homolog 1.23424
HSPA8 heat shock 70kDa protein 8 1.22177
H2AFX H2A histone family, member X 1.21468
XDH xanthine dehydrogenase 1.20654
TGFB1 transforming growth factor, beta 1 1.19509
PGRMC1 progesterone receptor membrane component 1 1.19279
PHYH phytanoyl-CoA 2-hydroxylase 1.18587
IGF1 insulin-like growth factor 1 (somatomedin C) 1.18391
CALD1 caldesmon 1 1.17926
TP53 tumor protein p53 1.17596
KRT1 keratin 1, type II 1.17596
HMOX1 heme oxygenase 1 1.1753
CD59 CD59 molecule, complement regulatory protein 1.173
TMEM97 transmembrane protein 97 1.16666
CCNA2 cyclin A2 1.16567
EPHA2 EPH receptor A2 1.16368
SRXN1 sulfiredoxin 1 1.15223
ATF3 activating transcription factor 3 1.15223
SGK1 serum/glucocorticoid regulated kinase 1 1.13415
ECI1 enoyl-CoA delta isomerase 1 1.13211
CCND2 cyclin D2 1.13007
TNF tumor necrosis factor 1.12599
MGMT O-6-methylguanine-DNA methyltransferase 1.12461
PRC1 protein regulator of cytokinesis 1 1.11707
TIMP1 TIMP metallopeptidase inhibitor 1 1.11501
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 1.11466
COL18A1 collagen, type XVIII, alpha 1 1.11431
BIRC5 baculoviral IAP repeat containing 5 1.11011
CPT2 carnitine palmitoyltransferase 2 1.10734
TRIAP1 TP53 regulated inhibitor of apoptosis 1 1.10104
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.09786
IL1B interleukin 1, beta 1.09751
VEGFC vascular endothelial growth factor C 1.09541
CCNB1 cyclin B1 1.08904
IGFBP3 insulin-like growth factor binding protein 3 1.08797
CKS2 CDC28 protein kinase regulatory subunit 2 1.08655
NUSAP1 nucleolar and spindle associated protein 1 1.08196
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 1.08196
LTBP2 latent transforming growth factor beta binding protein 2 1.08019
MT3 metallothionein 3 1.07768
MAPK3 mitogen-activated protein kinase 3 1.07768
JAK1 Janus kinase 1 1.07589
TRA2B transformer 2 beta homolog (Drosophila) 1.07553
FABP5 fatty acid binding protein 5 (psoriasis-associated) 1.07163
APP amyloid beta (A4) precursor protein 1.07093
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 1.07057
PCNA proliferating cell nuclear antigen 1.07022
CRYAA crystallin, alpha A 1.06987
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 1.06771
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.06734
CTGF connective tissue growth factor 1.06698
PELO pelota homolog (Drosophila) 1.06661
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.06625
CXCL5 chemokine (C-X-C motif) ligand 5 1.06552
TNC tenascin C 1.06515
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 1.06333
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 1.06261
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.06225
FAS Fas cell surface death receptor 1.06152
TOP2A topoisomerase (DNA) II alpha 170kDa 1.06116
GDF15 growth differentiation factor 15 1.06116
G6PD glucose-6-phosphate dehydrogenase 1.06008
S100A4 S100 calcium binding protein A4 1.05936
IL1A interleukin 1, alpha 1.05864
PARD6G par-6 family cell polarity regulator gamma 1.05793
HMGB2 high mobility group box 2 1.05498
TSC22D3 TSC22 domain family, member 3 1.05312
NEUROD1 neuronal differentiation 1 1.052
ALDOA aldolase A, fructose-bisphosphate 1.05163
CAT catalase 1.05052
LYPLA1 lysophospholipase I 1.04794
IFRD1 interferon-related developmental regulator 1 1.04757
UBE2C ubiquitin-conjugating enzyme E2C 1.04574
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 1.04389
LMNA lamin A/C 1.04389
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.04389
CUX1 cut-like homeobox 1 1.04352
AURKA aurora kinase A 1.04201
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.04051
DDIT3 DNA-damage-inducible transcript 3 1.03827
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 1.03827
JUN jun proto-oncogene 1.03827
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 1.03641
CTH cystathionine gamma-lyase 1.02896
DKK3 dickkopf WNT signaling pathway inhibitor 3 1.02783
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 1.02783
TCF3 transcription factor 3 1.02746
POR P450 (cytochrome) oxidoreductase 1.02596
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.02596
LTBP1 latent transforming growth factor beta binding protein 1 1.02373
PRDX2 peroxiredoxin 2 1.02188
RUNX3 runt-related transcription factor 3 1.01701
GPSM2 G-protein signaling modulator 2 1.01701
COL8A1 collagen, type VIII, alpha 1 1.01663
GDF10 growth differentiation factor 10 1.01625
MPG N-methylpurine-DNA glycosylase 1.01361
COL6A2 collagen, type VI, alpha 2 1.01361
DSC2 desmocollin 2 1.01324
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.01212
MAPK8 mitogen-activated protein kinase 8 1.01062