Skin Neoplasms Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

294 genes associated with the Skin Neoplasms phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
ACO1 aconitase 1, soluble
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANKK1 ankyrin repeat and kinase domain containing 1
AP3B1 adaptor-related protein complex 3, beta 1 subunit
APC adenomatous polyposis coli
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
AS3MT arsenite methyltransferase
ASIP agouti signaling protein
ATRN attractin
AURKA aurora kinase A
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BAX BCL2-associated X protein
BCCIP BRCA2 and CDKN1A interacting protein
BCL2 B-cell CLL/lymphoma 2
BMP4 bone morphogenetic protein 4
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAT catalase
CCND1 cyclin D1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD28 CD28 molecule
CD3EAP CD3e molecule, epsilon associated protein
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2B-AS1 CDKN2B antisense RNA 1
CHEK2 checkpoint kinase 2
CLPTM1 cleft lip and palate associated transmembrane protein 1
CLPTM1L CLPTM1-like
COL18A1 collagen, type XVIII, alpha 1
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDB1 damage-specific DNA binding protein 1, 127kDa
DDIT3 DNA-damage-inducible transcript 3
DRD2 dopamine receptor D2
DUSP14 dual specificity phosphatase 14
EDN1 endothelin 1
EDNRB endothelin receptor type B
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
ERCC6 excision repair cross-complementation group 6
ESR1 estrogen receptor 1
EXOC2 exocyst complex component 2
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBRSL1 fibrosin-like 1
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FLG filaggrin
FLT1 fms-related tyrosine kinase 1
FOXE1 forkhead box E1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GC group-specific component (vitamin D binding protein)
GDNF glial cell derived neurotrophic factor
GLI1 GLI family zinc finger 1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNAS GNAS complex locus
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GPX1 glutathione peroxidase 1
GSTA4 glutathione S-transferase alpha 4
GSTM1 glutathione S-transferase mu 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTO2 glutathione S-transferase omega 2
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HAL histidine ammonia-lyase
HDAC9 histone deacetylase 9
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HFE hemochromatosis
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HPS1 Hermansky-Pudlak syndrome 1
HRAS Harvey rat sarcoma viral oncogene homolog
HRH2 histamine receptor H2
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
ICAM1 intercellular adhesion molecule 1
ICOS inducible T-cell co-stimulator
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFNA1 interferon, alpha 1
IFNA10 interferon, alpha 10
IFNA14 interferon, alpha 14
IFNA16 interferon, alpha 16
IFNA17 interferon, alpha 17
IFNA2 interferon, alpha 2
IFNA21 interferon, alpha 21
IFNA5 interferon, alpha 5
IFNA6 interferon, alpha 6
IFNA8 interferon, alpha 8
IFNB1 interferon, beta 1, fibroblast
IFNE interferon, epsilon
IFNG interferon, gamma
IFNK interferon, kappa
IFNW1 interferon, omega 1
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IHH indian hedgehog
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IL6R interleukin 6 receptor
IRF4 interferon regulatory factor 4
ITGA10 integrin, alpha 10
ITGA11 integrin, alpha 11
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA6 integrin, alpha 6
ITGA7 integrin, alpha 7
ITGA9 integrin, alpha 9
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
ITGB4 integrin, beta 4
ITGB5 integrin, beta 5
KEAP1 kelch-like ECH-associated protein 1
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KLC1 kinesin light chain 1
KLF14 Kruppel-like factor 14
KLHL9 kelch-like family member 9
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT5 keratin 5, type II
LIG3 ligase III, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
LTA lymphotoxin alpha
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K2 mitogen-activated protein kinase kinase 2
MBS1 Moebius syndrome 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase
MIR146A microRNA 146a
MIR34A microRNA 34a
MITF microphthalmia-associated transcription factor
MLANA melan-A
MLH1 mutL homolog 1
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MTAP methylthioadenosine phosphorylase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUTYH mutY homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYD88 myeloid differentiation primary response 88
MYH7B myosin, heavy chain 7B, cardiac muscle, beta
MYO5A myosin VA (heavy chain 12, myoxin)
MYO7A myosin VIIA
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NBN nibrin
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID1 nidogen 1
NLRP1 NLR family, pyrin domain containing 1
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
OA1 Osteoarthritis QTL 1
OCA2 oculocutaneous albinism II
OGG1 8-oxoguanine DNA glycosylase
PADI4 peptidyl arginine deiminase, type IV
PADI6 peptidyl arginine deiminase, type VI
PARP1 poly (ADP-ribose) polymerase 1
PAX3 paired box 3
PDGFD platelet derived growth factor D
PHB prohibitin
PIGU phosphatidylinositol glycan anchor biosynthesis, class U
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLAA phospholipase A2-activating protein
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLH polymerase (DNA directed), eta
POMC proopiomelanocortin
POT1 protection of telomeres 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PTCH1 patched 1
PTCH2 patched 2
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2B protein tyrosine kinase 2 beta
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RCC2 regulator of chromosome condensation 2
RECQL4 RecQ protein-like 4
RET ret proto-oncogene
RFC1 replication factor C (activator 1) 1, 145kDa
RGS22 regulator of G-protein signaling 22
RHOU ras homolog family member U
RMI1 RecQ mediated genome instability 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNH1 ribonuclease/angiogenin inhibitor 1
RTEL1 regulator of telomere elongation helicase 1
SHFM1 split hand/foot malformation (ectrodactyly) type 1
SHH sonic hedgehog
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5
SLC45A2 solute carrier family 45, member 2
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMO smoothened, frizzled class receptor
SOD2 superoxide dismutase 2, mitochondrial
SOX10 SRY (sex determining region Y)-box 10
STX17 syntaxin 17
SUFU suppressor of fused homolog (Drosophila)
TDG thymine-DNA glycosylase
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TERF2 telomeric repeat binding factor 2
TERF2IP telomeric repeat binding factor 2, interacting protein
TERT telomerase reverse transcriptase
TET2 tet methylcytosine dioxygenase 2
TGFB1 transforming growth factor, beta 1
TGM3 transglutaminase 3
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TNF tumor necrosis factor
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TUSC1 tumor suppressor candidate 1
TYR tyrosinase
TYRP1 tyrosinase-related protein 1
UBAC2 UBA domain containing 2
VASH2 vasohibin 2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VPS13B vacuolar protein sorting 13 homolog B (yeast)
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZFYVE21 zinc finger, FYVE domain containing 21