Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MK-06A-11R-A18S-07 Gene Set

Dataset TCGA Signatures of Differentially Expressed Genes for Tumors
Category transcriptomics
Type tissue sample
Description tissue sample derived from Skin Cutaneous Melanoma_SKCM (The Cancer Genome Atlas)
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Genes

447 genes with high or low expression in Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MK-06A-11R-A18S-07 relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.

high expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD16A abhydrolase domain containing 16A
ABLIM3 actin binding LIM protein family, member 3
ACOT13 acyl-CoA thioesterase 13
ACSL4 acyl-CoA synthetase long-chain family member 4
ACY3 aminoacylase 3
AEBP1 AE binding protein 1
AFAP1L1 actin filament associated protein 1-like 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALG1L2 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like 2
AMACR alpha-methylacyl-CoA racemase
AMD1 adenosylmethionine decarboxylase 1
AMIGO1 adhesion molecule with Ig-like domain 1
ANKRD42 ankyrin repeat domain 42
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
AP4M1 adaptor-related protein complex 4, mu 1 subunit
APOL3 apolipoprotein L, 3
ARFIP1 ADP-ribosylation factor interacting protein 1
ARGFX arginine-fifty homeobox
ARHGAP31 Rho GTPase activating protein 31
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARIH2OS ariadne homolog 2 opposite strand
ARL14EP ADP-ribosylation factor-like 14 effector protein
ARMC10 armadillo repeat containing 10
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX3 armadillo repeat containing, X-linked 3
ARMCX5 armadillo repeat containing, X-linked 5
ARMCX6 armadillo repeat containing, X-linked 6
ARSK arylsulfatase family, member K
ATAD1 ATPase family, AAA domain containing 1
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
ATRX alpha thalassemia/mental retardation syndrome X-linked
ATXN1 ataxin 1
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BACE1 beta-site APP-cleaving enzyme 1
BBS9 Bardet-Biedl syndrome 9
BBX bobby sox homolog (Drosophila)
BET1 Bet1 golgi vesicular membrane trafficking protein
BPGM 2,3-bisphosphoglycerate mutase
BPIFA1 BPI fold containing family A, member 1
BTN2A1 butyrophilin, subfamily 2, member A1
BTN3A1 butyrophilin, subfamily 3, member A1
BTN3A2 butyrophilin, subfamily 3, member A2
BTN3A3 butyrophilin, subfamily 3, member A3
C19ORF57 chromosome 19 open reading frame 57
C1GALT1C1 C1GALT1-specific chaperone 1
C2 complement component 2
C4A complement component 4A (Rodgers blood group)
C4ORF3 chromosome 4 open reading frame 3
C4ORF36 chromosome 4 open reading frame 36
C4ORF45 chromosome 4 open reading frame 45
C5ORF45 chromosome 5 open reading frame 45
C6ORF47 chromosome 6 open reading frame 47
C6ORF89 chromosome 6 open reading frame 89
C7ORF25 chromosome 7 open reading frame 25
C7ORF60 chromosome 7 open reading frame 60
CADPS2 Ca++-dependent secretion activator 2
CALD1 caldesmon 1
CAMLG calcium modulating ligand
CAPN5 calpain 5
CARD6 caspase recruitment domain family, member 6
CASC3 cancer susceptibility candidate 3
CAV1 caveolin 1, caveolae protein, 22kDa
CBX7 chromobox homolog 7
CCDC110 coiled-coil domain containing 110
CCDC126 coiled-coil domain containing 126
CCDC129 coiled-coil domain containing 129
CCDC132 coiled-coil domain containing 132
CCDC160 coiled-coil domain containing 160
CCDC87 coiled-coil domain containing 87
CCDC89 coiled-coil domain containing 89
CD200 CD200 molecule
CD59 CD59 molecule, complement regulatory protein
CDADC1 cytidine and dCMP deaminase domain containing 1
CDK14 cyclin-dependent kinase 14
CEP120 centrosomal protein 120kDa
CEP41 centrosomal protein 41kDa
CGGBP1 CGG triplet repeat binding protein 1
CHL1 cell adhesion molecule L1-like
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CNGA1 cyclic nucleotide gated channel alpha 1
CNOT4 CCR4-NOT transcription complex, subunit 4
CPNE5 copine V
CREB5 cAMP responsive element binding protein 5
CSRP1 cysteine and glycine-rich protein 1
CTF1 cardiotrophin 1
CTSO cathepsin O
CWF19L2 CWF19-like 2, cell cycle control (S. pombe)
CXXC5 CXXC finger protein 5
CYB5D1 cytochrome b5 domain containing 1
DDR1 discoidin domain receptor tyrosine kinase 1
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DHFRL1 dihydrofolate reductase-like 1
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29
DIXDC1 DIX domain containing 1
DLC1 DLC1 Rho GTPase activating protein
DTNBP1 dystrobrevin binding protein 1
DUSP22 dual specificity phosphatase 22
ECI2 enoyl-CoA delta isomerase 2
EFHC1 EF-hand domain (C-terminal) containing 1
ERAP2 endoplasmic reticulum aminopeptidase 2
ETV1 ets variant 1
EXOC4 exocyst complex component 4
EYA1 EYA transcriptional coactivator and phosphatase 1
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FAM104B family with sequence similarity 104, member B
FAM120C family with sequence similarity 120C
FAM122B family with sequence similarity 122B
FAM13B family with sequence similarity 13, member B
FAM149A family with sequence similarity 149, member A
FAM151B family with sequence similarity 151, member B
FAM173B family with sequence similarity 173, member B
FAM185A family with sequence similarity 185, member A
FAM196B family with sequence similarity 196, member B
FAM200A family with sequence similarity 200, member A
FAM215A family with sequence similarity 215, member A (non-protein coding)
FAM220A family with sequence similarity 220, member A
FAM8A1 family with sequence similarity 8, member A1
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial
FAXDC2 fatty acid hydroxylase domain containing 2
FBXL20 F-box and leucine-rich repeat protein 20
FBXL5 F-box and leucine-rich repeat protein 5
FBXO3 F-box protein 3
FBXO9 F-box protein 9
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FLJ36777 uncharacterized LOC730971
FOXO4 forkhead box O4
FOXP4 forkhead box P4
FRMD3 FERM domain containing 3
FUNDC2 FUN14 domain containing 2
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GLCE glucuronic acid epimerase
GNPDA2 glucosamine-6-phosphate deaminase 2
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPRASP1 G protein-coupled receptor associated sorting protein 1
GPRASP2 G protein-coupled receptor associated sorting protein 2
GRAMD3 GRAM domain containing 3
GSAP gamma-secretase activating protein
HBP1 HMG-box transcription factor 1
HCG26 HLA complex group 26 (non-protein coding)
HCP5 HLA complex P5 (non-protein coding)
HDX highly divergent homeobox
HFE hemochromatosis
HIBADH 3-hydroxyisobutyrate dehydrogenase
HIP1 huntingtin interacting protein 1
HIST1H2AG histone cluster 1, H2ag
HIST1H3E histone cluster 1, H3e
HIST1H4I histone cluster 1, H4i
HKDC1 hexokinase domain containing 1
HMGN4 high mobility group nucleosomal binding domain 4
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H')
HOXA7 homeobox A7
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSPA12A heat shock 70kDa protein 12A
HSPA7 heat shock 70kDa protein 7 (HSP70B)
ICAM1 intercellular adhesion molecule 1
IDUA iduronidase, alpha-L-
IFT22 intraflagellar transport 22
IFT46 intraflagellar transport 46
IFT88 intraflagellar transport 88
IGIP IgA-inducing protein
IL27RA interleukin 27 receptor, alpha
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JPX JPX transcript, XIST activator (non-protein coding)
KALRN kalirin, RhoGEF kinase
KBTBD3 kelch repeat and BTB (POZ) domain containing 3
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD14 potassium channel tetramerization domain containing 14
KCTD2 potassium channel tetramerization domain containing 2
KCTD20 potassium channel tetramerization domain containing 20
KCTD6 potassium channel tetramerization domain containing 6
KDELC2 KDEL (Lys-Asp-Glu-Leu) containing 2
KDM6A lysine (K)-specific demethylase 6A
KIAA1755 KIAA1755
KIF13A kinesin family member 13A
KIF9 kinesin family member 9
KLHDC9 kelch domain containing 9
KLHL10 kelch-like family member 10
KLHL13 kelch-like family member 13
KLHL7 kelch-like family member 7
KMT2E lysine (K)-specific methyltransferase 2E
LGI4 leucine-rich repeat LGI family, member 4
LINC00324 long intergenic non-protein coding RNA 324
LOC100129550 uncharacterized LOC100129550
LOC100131496 uncharacterized LOC100131496
LOC113230 uncharacterized protein LOC113230
LOC441204 uncharacterized LOC441204
LOC653653 adaptor-related protein complex 1, sigma 2 subunit pseudogene
LOC728024 chromosome X open reading frame 56 pseudogene
LRCH2 leucine-rich repeats and calponin homology (CH) domain containing 2
LRRC37BP1 leucine rich repeat containing 37B pseudogene 1
LRRN3 leucine rich repeat neuronal 3
LRTOMT leucine rich transmembrane and O-methyltransferase domain containing
LSAMP limbic system-associated membrane protein
LYZL1 lysozyme-like 1
MAGEE1 melanoma antigen family E1
MAGEH1 melanoma antigen family H1
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MANBA mannosidase, beta A, lysosomal
MAOB monoamine oxidase B
MAP9 microtubule-associated protein 9
MARC2 mitochondrial amidoxime reducing component 2
MCHR1 melanin-concentrating hormone receptor 1
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1
MED29 mediator complex subunit 29
METTL14 methyltransferase like 14
MFAP3L microfibrillar-associated protein 3-like
MFSD6 major facilitator superfamily domain containing 6
MICALL2 MICAL-like 2
MILR1 mast cell immunoglobulin-like receptor 1
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MMAA methylmalonic aciduria (cobalamin deficiency) cblA type
MPHOSPH8 M-phase phosphoprotein 8
MRAP2 melanocortin 2 receptor accessory protein 2
MRAS muscle RAS oncogene homolog
MRC1 mannose receptor, C type 1
MRFAP1L1 Morf4 family associated protein 1-like 1
MSANTD4 Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
MSN moesin
MUT methylmalonyl CoA mutase
MYO5B myosin VB
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2
NCAM1 neural cell adhesion molecule 1
NDUFA4 NDUFA4, mitochondrial complex associated
NES nestin
NFE2L3 nuclear factor, erythroid 2-like 3
NKAPP1 NFKB activating protein pseudogene 1
NKIRAS1 NFKB inhibitor interacting Ras-like 1
NMNAT3 nicotinamide nucleotide adenylyltransferase 3
NNMT nicotinamide N-methyltransferase
NR3C2 nuclear receptor subfamily 3, group C, member 2
NRCAM neuronal cell adhesion molecule
NTN4 netrin 4
NUB1 negative regulator of ubiquitin-like proteins 1
NUDCD3 NudC domain containing 3
OR10H4 olfactory receptor, family 10, subfamily H, member 4
OR2L13 olfactory receptor, family 2, subfamily L, member 13
OR2L3 olfactory receptor, family 2, subfamily L, member 3
OR2L8 olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)
OR4X2 olfactory receptor, family 4, subfamily X, member 2 (gene/pseudogene)
OR6N2 olfactory receptor, family 6, subfamily N, member 2
OSBPL10 oxysterol binding protein-like 10
PABPC5 poly(A) binding protein, cytoplasmic 5
PAQR8 progestin and adipoQ receptor family member VIII
PATE1 prostate and testis expressed 1
PATE2 prostate and testis expressed 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH7 protocadherin 7
PCDH9 protocadherin 9
PCDHB10 protocadherin beta 10
PCDHB11 protocadherin beta 11
PCDHB15 protocadherin beta 15
PCDHB16 protocadherin beta 16
PCDHB7 protocadherin beta 7
PCDHGA12 protocadherin gamma subfamily A, 12
PCDHGA2 protocadherin gamma subfamily A, 2
PCDHGB5 protocadherin gamma subfamily B, 5
PCDHGB6 protocadherin gamma subfamily B, 6
PCDHGB7 protocadherin gamma subfamily B, 7
PCDHGC3 protocadherin gamma subfamily C, 3
PEX12 peroxisomal biogenesis factor 12
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGAM2 phosphoglycerate mutase 2 (muscle)
PGBD1 piggyBac transposable element derived 1
PGRMC1 progesterone receptor membrane component 1
PHF1 PHD finger protein 1
PHF8 PHD finger protein 8
PHLDB1 pleckstrin homology-like domain, family B, member 1
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
PLA2G5 phospholipase A2, group V
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLS3 plastin 3
PNPLA8 patatin-like phospholipase domain containing 8
PODNL1 podocan-like 1
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2
POU3F3 POU class 3 homeobox 3
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PPP1R18 protein phosphatase 1, regulatory subunit 18
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1
PRELP proline/arginine-rich end leucine-rich repeat protein
PRICKLE2 prickle homolog 2 (Drosophila)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRM1 protamine 1
PROS1 protein S (alpha)
PROX1 prospero homeobox 1
PSD2 pleckstrin and Sec7 domain containing 2
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAB41 RAB41, member RAS oncogene family
RAB43 RAB43, member RAS oncogene family
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
RABL3 RAB, member of RAS oncogene family-like 3
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBP2 retinol binding protein 2, cellular
REEP5 receptor accessory protein 5
RGS4 regulator of G-protein signaling 4
RIBC1 RIB43A domain with coiled-coils 1
RNASE4 ribonuclease, RNase A family, 4
RNF180 ring finger protein 180
RNF186 ring finger protein 186
RNF216 ring finger protein 216
RNF5P1 ring finger protein 5, E3 ubiquitin protein ligase pseudogene 1
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
ROM1 retinal outer segment membrane protein 1
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RRAGB Ras-related GTP binding B
RSPH9 radial spoke head 9 homolog (Chlamydomonas)
SAMD9L sterile alpha motif domain containing 9-like
SAP30L SAP30-like
SBDS Shwachman-Bodian-Diamond syndrome
SCN1B sodium channel, voltage gated, type I beta subunit
SCN2B sodium channel, voltage gated, type II beta subunit
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
SERF1A small EDRK-rich factor 1A (telomeric)
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SIAE sialic acid acetylesterase
SKAP2 src kinase associated phosphoprotein 2
SKP1 S-phase kinase-associated protein 1
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC25A30 solute carrier family 25, member 30
SLC35A5 solute carrier family 35, member A5
SMAD7 SMAD family member 7
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMG9 SMG9 nonsense mediated mRNA decay factor
SMO smoothened, frizzled class receptor
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNED1 sushi, nidogen and EGF-like domains 1
SOBP sine oculis binding protein homolog (Drosophila)
SORCS1 sortilin-related VPS10 domain containing receptor 1
SPAG8 sperm associated antigen 8
SPATA9 spermatogenesis associated 9
SPEF2 sperm flagellar 2
SPIN2B spindlin family, member 2B
SPRY4 sprouty homolog 4 (Drosophila)
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1
SSMEM1 serine-rich single-pass membrane protein 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STAT5B signal transducer and activator of transcription 5B
STEAP2 STEAP family member 2, metalloreductase
SYNM synemin, intermediate filament protein
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBC1D19 TBC1 domain family, member 19
TBCK TBC1 domain containing kinase
TBX3 T-box 3
TCAF1 TRPM8 channel-associated factor 1
TCEAL1 transcription elongation factor A (SII)-like 1
TCEAL3 transcription elongation factor A (SII)-like 3
TCEAL4 transcription elongation factor A (SII)-like 4
TCEAL5 transcription elongation factor A (SII)-like 5
TCEAL6 transcription elongation factor A (SII)-like 6
TCTEX1D1 Tctex1 domain containing 1
TCTEX1D2 Tctex1 domain containing 2
TDP2 tyrosyl-DNA phosphodiesterase 2
TES testin LIM domain protein
TIGD4 tigger transposable element derived 4
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TLR1 toll-like receptor 1
TLR3 toll-like receptor 3
TM2D2 TM2 domain containing 2
TMED4 transmembrane emp24 protein transport domain containing 4
TMEM14C transmembrane protein 14C
TMEM218 transmembrane protein 218
TMEM248 transmembrane protein 248
TMEM27 transmembrane protein 27
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TPMT thiopurine S-methyltransferase
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
TRAPPC2 trafficking protein particle complex 2
TRIM3 tripartite motif containing 3
TRIM31 tripartite motif containing 31
TRIM36 tripartite motif containing 36
TRIM38 tripartite motif containing 38
TRIM39 tripartite motif containing 39
TRIM4 tripartite motif containing 4
TRIM56 tripartite motif containing 56
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TSC22D1 TSC22 domain family, member 1
TSPAN14 tetraspanin 14
TSPAN33 tetraspanin 33
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
TTC12 tetratricopeptide repeat domain 12
TTC30A tetratricopeptide repeat domain 30A
TTC33 tetratricopeptide repeat domain 33
TXNDC15 thioredoxin domain containing 15
TYW1B tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)
UBE2A ubiquitin-conjugating enzyme E2A
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative)
UBE2H ubiquitin-conjugating enzyme E2H
UBQLN2 ubiquilin 2
UFSP2 UFM1-specific peptidase 2
UPP2 uridine phosphorylase 2
UPRT uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
URGCP upregulator of cell proliferation
USP27X ubiquitin specific peptidase 27, X-linked
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VIL1 villin 1
VPS37D vacuolar protein sorting 37 homolog D (S. cerevisiae)
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae)
VWC2L von Willebrand factor C domain containing protein 2-like
WDR19 WD repeat domain 19
WDR44 WD repeat domain 44
WNK4 WNK lysine deficient protein kinase 4
XCL2 chemokine (C motif) ligand 2
YIPF3 Yip1 domain family, member 3
YPEL4 yippee-like 4 (Drosophila)
YY2 YY2 transcription factor
ZBTB4 zinc finger and BTB domain containing 4
ZCWPW2 zinc finger, CW type with PWWP domain 2
ZFP14 ZFP14 zinc finger protein
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF154 zinc finger protein 154
ZNF181 zinc finger protein 181
ZNF214 zinc finger protein 214
ZNF3 zinc finger protein 3
ZNF322P1 zinc finger protein 322 pseudogene 1
ZNF420 zinc finger protein 420
ZNF441 zinc finger protein 441
ZNF471 zinc finger protein 471
ZNF501 zinc finger protein 501
ZNF502 zinc finger protein 502
ZNF560 zinc finger protein 560
ZNF569 zinc finger protein 569
ZNF582 zinc finger protein 582
ZNF583 zinc finger protein 583
ZNF614 zinc finger protein 614
ZNF615 zinc finger protein 615
ZNF630 zinc finger protein 630
ZNF671 zinc finger protein 671
ZNF763 zinc finger protein 763
ZNF788 zinc finger family member 788
ZNF790 zinc finger protein 790
ZNF836 zinc finger protein 836
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2
ZSCAN16 zinc finger and SCAN domain containing 16
ZSCAN26 zinc finger and SCAN domain containing 26

low expression

Symbol Name
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein