Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51J-06A-11R-A266-07 Gene Set

Dataset TCGA Signatures of Differentially Expressed Genes for Tumors
Category transcriptomics
Type tissue sample
Description tissue sample derived from Skin Cutaneous Melanoma_SKCM (The Cancer Genome Atlas)
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Genes

434 genes with high or low expression in Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51J-06A-11R-A266-07 relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.

high expression

Symbol Name
AARS2 alanyl-tRNA synthetase 2, mitochondrial
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)
ACCSL 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like
ACSL6 acyl-CoA synthetase long-chain family member 6
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
ADAMTSL3 ADAMTS-like 3
ADARB1 adenosine deaminase, RNA-specific, B1
ADGRG2 adhesion G protein-coupled receptor G2
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADI1 acireductone dioxygenase 1
ADRA2B adrenoceptor alpha 2B
AFAP1 actin filament associated protein 1
AHSA2 AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANGPTL5 angiopoietin-like 5
ANGPTL7 angiopoietin-like 7
ANKRD12 ankyrin repeat domain 12
ANKRD19P ankyrin repeat domain 19, pseudogene
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ANKRD20A4 ankyrin repeat domain 20 family, member A4
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ANXA4 annexin A4
APMAP adipocyte plasma membrane associated protein
AQP1 aquaporin 1 (Colton blood group)
ARHGAP26 Rho GTPase activating protein 26
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARIH2OS ariadne homolog 2 opposite strand
ARMC1 armadillo repeat containing 1
ARMS2 age-related maculopathy susceptibility 2
ARSB arylsulfatase B
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASB14 ankyrin repeat and SOCS box containing 14
ASPDH aspartate dehydrogenase domain containing
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP4B ATPase, H+/K+ exchanging, beta polypeptide
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
ATP7B ATPase, Cu++ transporting, beta polypeptide
BAALC brain and acute leukemia, cytoplasmic
BAALC-AS2 BAALC antisense RNA 2
BBS12 Bardet-Biedl syndrome 12
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BFSP1 beaded filament structural protein 1, filensin
BMP7 bone morphogenetic protein 7
BOC BOC cell adhesion associated, oncogene regulated
BOD1L1 biorientation of chromosomes in cell division 1-like 1
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BST2 bone marrow stromal cell antigen 2
C10ORF62 chromosome 10 open reading frame 62
C11ORF65 chromosome 11 open reading frame 65
C15ORF53 chromosome 15 open reading frame 53
C16ORF89 chromosome 16 open reading frame 89
C16ORF93 chromosome 16 open reading frame 93
C1ORF64 chromosome 1 open reading frame 64
C4ORF32 chromosome 4 open reading frame 32
C8ORF33 chromosome 8 open reading frame 33
C8ORF44 chromosome 8 open reading frame 44
C9ORF173 chromosome 9 open reading frame 173
C9ORF57 chromosome 9 open reading frame 57
CA13 carbonic anhydrase XIII
CA5B carbonic anhydrase VB, mitochondrial
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CACNG3 calcium channel, voltage-dependent, gamma subunit 3
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CC2D2A coiled-coil and C2 domain containing 2A
CCDC110 coiled-coil domain containing 110
CCDC129 coiled-coil domain containing 129
CCDC146 coiled-coil domain containing 146
CCDC64 coiled-coil domain containing 64
CCPG1 cell cycle progression 1
CCR8 chemokine (C-C motif) receptor 8
CCR9 chemokine (C-C motif) receptor 9
CDC14B cell division cycle 14B
CEP295 centrosomal protein 295kDa
CETN4P centrin EF-hand protein 4, pseudogene
CHRAC1 chromatin accessibility complex 1
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)
CLEC10A C-type lectin domain family 10, member A
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CMTM7 CKLF-like MARVEL transmembrane domain containing 7
COBL cordon-bleu WH2 repeat protein
COL27A1 collagen, type XXVII, alpha 1
COL8A2 collagen, type VIII, alpha 2
COL9A1 collagen, type IX, alpha 1
COQ10B coenzyme Q10 homolog B (S. cerevisiae)
CPM carboxypeptidase M
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)
CSPP1 centrosome and spindle pole associated protein 1
CSRNP3 cysteine-serine-rich nuclear protein 3
CST7 cystatin F (leukocystatin)
CTBP1 C-terminal binding protein 1
CTGF connective tissue growth factor
CTNNBIP1 catenin, beta interacting protein 1
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2
CYP4X1 cytochrome P450, family 4, subfamily X, polypeptide 1
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DAPL1 death associated protein-like 1
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEPTOR DEP domain containing MTOR-interacting protein
DERL1 derlin 1
DGKH diacylglycerol kinase, eta
DGKQ diacylglycerol kinase, theta 110kDa
DNAH9 dynein, axonemal, heavy chain 9
DNASE2B deoxyribonuclease II beta
DNM1P35 dynamin 1 pseudogene 35
DOCK10 dedicator of cytokinesis 10
DPYSL3 dihydropyrimidinase-like 3
DUSP7 dual specificity phosphatase 7
EBAG9 estrogen receptor binding site associated, antigen, 9
EFR3B EFR3 homolog B (S. cerevisiae)
EMC2 ER membrane protein complex subunit 2
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
ETNPPL ethanolamine-phosphate phospho-lyase
ETV1 ets variant 1
EVA1A eva-1 homolog A (C. elegans)
EVC Ellis van Creveld protein
EVC2 Ellis van Creveld syndrome 2
EXT1 exostosin glycosyltransferase 1
FAM149A family with sequence similarity 149, member A
FAM169A family with sequence similarity 169, member A
FAM180B family with sequence similarity 180, member B
FAM66C family with sequence similarity 66, member C
FANCD2OS FANCD2 opposite strand
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCHSD1 FCH and double SH3 domains 1
FGF2 fibroblast growth factor 2 (basic)
FGFBP2 fibroblast growth factor binding protein 2
FMOD fibromodulin
FOXB1 forkhead box B1
FOXD2 forkhead box D2
FOXD4L3 forkhead box D4-like 3
FOXN2 forkhead box N2
FOXP3 forkhead box P3
FRMD4B FERM domain containing 4B
FSD2 fibronectin type III and SPRY domain containing 2
FST follistatin
FZD6 frizzled class receptor 6
FZD7 frizzled class receptor 7
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
GBP4 guanylate binding protein 4
GEMIN8P4 gem (nuclear organelle) associated protein 8 pseudogene 4
GINS4 GINS complex subunit 4 (Sld5 homolog)
GJA5 gap junction protein, alpha 5, 40kDa
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GOLGA4 golgin A4
GOLGB1 golgin B1
GPRC5C G protein-coupled receptor, class C, group 5, member C
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GRIP2 glutamate receptor interacting protein 2
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
GSAP gamma-secretase activating protein
GSDMD gasdermin D
GSS glutathione synthetase
GTSF1L gametocyte specific factor 1-like
HABP2 hyaluronan binding protein 2
HHATL hedgehog acyltransferase-like
HOXA13 homeobox A13
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HRSP12 heat-responsive protein 12
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic
IAPP islet amyloid polypeptide
IDUA iduronidase, alpha-L-
IL18RAP interleukin 18 receptor accessory protein
IL3 interleukin 3
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6
ITM2B integral membrane protein 2B
KAZN kazrin, periplakin interacting protein
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4
KIAA0232 KIAA0232
KIAA1551 KIAA1551
KIAA1644 KIAA1644
KIAA2018 KIAA2018
KIF16B kinesin family member 16B
KIF1A kinesin family member 1A
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
KLHL34 kelch-like family member 34
KRCC1 lysine-rich coiled-coil 1
KRT222 keratin 222, type II
LAP3 leucine aminopeptidase 3
LDLRAD3 low density lipoprotein receptor class A domain containing 3
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LEFTY1 left-right determination factor 1
LEFTY2 left-right determination factor 2
LEPROTL1 leptin receptor overlapping transcript-like 1
LGI3 leucine-rich repeat LGI family, member 3
LHX1 LIM homeobox 1
LIMD2 LIM domain containing 2
LOC100130872 uncharacterized LOC100130872
LOC100133669 uncharacterized LOC100133669
LOC391322 D-dopachrome tautomerase-like
LOC641367 cyclin Y-like 1 pseudogene
LOC93622 Morf4 family associated protein 1-like 1 pseudogene
LPAR1 lysophosphatidic acid receptor 1
LPPR1 lipid phosphate phosphatase-related protein type 1
LRP2 low density lipoprotein receptor-related protein 2
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LRRC16A leucine rich repeat containing 16A
LY6E lymphocyte antigen 6 complex, locus E
LYNX1 Ly6/neurotoxin 1
M1AP meiosis 1 associated protein
MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
MAN2C1 mannosidase, alpha, class 2C, member 1
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MAPKBP1 mitogen-activated protein kinase binding protein 1
MARC2 mitochondrial amidoxime reducing component 2
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MCOLN2 mucolipin 2
MED28 mediator complex subunit 28
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MKRN2 makorin ring finger protein 2
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MOCS2 molybdenum cofactor synthesis 2
MRFAP1 Morf4 family associated protein 1
MRPL13 mitochondrial ribosomal protein L13
MRPS6 mitochondrial ribosomal protein S6
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1M metallothionein 1M
MTBP MDM2 binding protein
MTERF3 mitochondrial transcription termination factor 3
MTSS1 metastasis suppressor 1
MUC7 mucin 7, secreted
NAAA N-acylethanolamine acid amidase
NAPRT nicotinate phosphoribosyltransferase
NBN nibrin
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NELL1 NEL-like 1 (chicken)
NPSR1 neuropeptide S receptor 1
NRBP2 nuclear receptor binding protein 2
NRIP2 nuclear receptor interacting protein 2
NRK Nik related kinase
NRROS negative regulator of reactive oxygen species
NSG1 neuron specific gene family member 1
NSUN5P1 NOP2/Sun domain family, member 5 pseudogene 1
OR14C36 olfactory receptor, family 14, subfamily C, member 36
OR2A5 olfactory receptor, family 2, subfamily A, member 5
OR2AE1 olfactory receptor, family 2, subfamily AE, member 1
OR2G3 olfactory receptor, family 2, subfamily G, member 3
OR4C16 olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)
OR52B2 olfactory receptor, family 52, subfamily B, member 2
OR52I1 olfactory receptor, family 52, subfamily I, member 1
OR8D2 olfactory receptor, family 8, subfamily D, member 2 (gene/pseudogene)
OSBPL3 oxysterol binding protein-like 3
OXCT1 3-oxoacid CoA transferase 1
P3H2 prolyl 3-hydroxylase 2
PABPC5 poly(A) binding protein, cytoplasmic 5
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PALD1 phosphatase domain containing, paladin 1
PARP10 poly (ADP-ribose) polymerase family, member 10
PAX2 paired box 2
PAX9 paired box 9
PCSK5 proprotein convertase subtilisin/kexin type 5
PGM5 phosphoglucomutase 5
PIFO primary cilia formation
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
POU3F3 POU class 3 homeobox 3
PPP4R1L protein phosphatase 4, regulatory subunit 1-like (pseudogene)
PRMT7 protein arginine methyltransferase 7
PRX periaxin
PTPRG protein tyrosine phosphatase, receptor type, G
PYCR2 pyrroline-5-carboxylate reductase family, member 2
PYGO1 pygopus family PHD finger 1
PYROXD2 pyridine nucleotide-disulphide oxidoreductase domain 2
QDPR quinoid dihydropteridine reductase
RAB28 RAB28, member RAS oncogene family
RAB39B RAB39B, member RAS oncogene family
RAD21 RAD21 homolog (S. pombe)
RAD54B RAD54 homolog B (S. cerevisiae)
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBBP6 retinoblastoma binding protein 6
RBM20 RNA binding motif protein 20
RELL2 RELT-like 2
RGS12 regulator of G-protein signaling 12
RGS2 regulator of G-protein signaling 2
RGS3 regulator of G-protein signaling 3
RHBDL1 rhomboid, veinlet-like 1 (Drosophila)
RHBDL3 rhomboid, veinlet-like 3 (Drosophila)
RHPN1 rhophilin, Rho GTPase binding protein 1
RIF1 replication timing regulatory factor 1
RMDN1 regulator of microtubule dynamics 1
RNASEH2C ribonuclease H2, subunit C
RNF207 ring finger protein 207
RNF4 ring finger protein 4
RNF43 ring finger protein 43
RPH3AL rabphilin 3A-like (without C2 domains)
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RRN3P2 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 2
S1PR5 sphingosine-1-phosphate receptor 5
SAA3P serum amyloid A3 pseudogene
SAMD4A sterile alpha motif domain containing 4A
SAMHD1 SAM domain and HD domain 1
SDC2 syndecan 2
SDCBP syndecan binding protein (syntenin)
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SEPT11 septin 11
SEPW1 selenoprotein W, 1
SETD2 SET domain containing 2
SGK3 serum/glucocorticoid regulated kinase family, member 3
SGSM2 small G protein signaling modulator 2
SHD Src homology 2 domain containing transforming protein D
SIGLEC11 sialic acid binding Ig-like lectin 11
SLBP stem-loop binding protein
SLC16A4 solute carrier family 16, member 4
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC25A30 solute carrier family 25, member 30
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC26A1 solute carrier family 26 (anion exchanger), member 1
SLC30A2 solute carrier family 30 (zinc transporter), member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SNORA34 small nucleolar RNA, H/ACA box 34
SNORA45B small nucleolar RNA, H/ACA box 45B
SNORA5C small nucleolar RNA, H/ACA box 5C
SNX10 sorting nexin 10
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX8 SRY (sex determining region Y)-box 8
SPAG1 sperm associated antigen 1
SPARCL1 SPARC-like 1 (hevin)
SPATA22 spermatogenesis associated 22
SPATS1 spermatogenesis associated, serine-rich 1
SPDYE8P speedy/RINGO cell cycle regulator family member E8, pseudogene
SPN sialophorin
SPON2 spondin 2, extracellular matrix protein
SPPL3 signal peptide peptidase like 3
SSBP2 single-stranded DNA binding protein 2
STAG3L2 stromal antigen 3-like 2 (pseudogene)
STAMBPL1 STAM binding protein-like 1
STK10 serine/threonine kinase 10
STPG2 sperm-tail PG-rich repeat containing 2
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1
SUMO1P1 SUMO1 pseudogene 1
SYNM synemin, intermediate filament protein
SYNPO2 synaptopodin 2
TAAR6 trace amine associated receptor 6
TAAR8 trace amine associated receptor 8
TAAR9 trace amine associated receptor 9 (gene/pseudogene)
TAC4 tachykinin 4 (hemokinin)
TADA2B transcriptional adaptor 2B
TAPT1 transmembrane anterior posterior transformation 1
TBC1D29 TBC1 domain family, member 29
TBC1D4 TBC1 domain family, member 4
TBL1Y transducin (beta)-like 1, Y-linked
TCEA1 transcription elongation factor A (SII), 1
TCTE1 t-complex-associated-testis-expressed 1
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
THEM6 thioesterase superfamily member 6
TIAM2 T-cell lymphoma invasion and metastasis 2
TIFAB TRAF-interacting protein with forkhead-associated domain, family member B
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKFC triokinase/FMN cyclase
TLDC2 TBC/LysM-associated domain containing 2
TLE6 transducin-like enhancer of split 6
TMBIM4 transmembrane BAX inhibitor motif containing 4
TMEM106A transmembrane protein 106A
TMEM128 transmembrane protein 128
TMEM129 transmembrane protein 129, E3 ubiquitin protein ligase
TMEM175 transmembrane protein 175
TMEM220 transmembrane protein 220
TMEM230 transmembrane protein 230
TMEM27 transmembrane protein 27
TMEM47 transmembrane protein 47
TMEM50B transmembrane protein 50B
TMEM54 transmembrane protein 54
TMEM55A transmembrane protein 55A
TMEM68 transmembrane protein 68
TMEM80 transmembrane protein 80
TMEM82 transmembrane protein 82
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TPD52 tumor protein D52
TRAPPC9 trafficking protein particle complex 9
TRIP11 thyroid hormone receptor interactor 11
TSPAN32 tetraspanin 32
TSPAN5 tetraspanin 5
TSPAN7 tetraspanin 7
TSSK6 testis-specific serine kinase 6
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UBE2W ubiquitin-conjugating enzyme E2W (putative)
UBTFL1 upstream binding transcription factor, RNA polymerase I-like 1
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
UTP23 UTP23, small subunit (SSU) processome component, homolog (yeast)
UVSSA UV-stimulated scaffold protein A
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAMP5 vesicle-associated membrane protein 5
VAMP8 vesicle-associated membrane protein 8
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VN1R2 vomeronasal 1 receptor 2
WDR1 WD repeat domain 1
WFS1 Wolfram syndrome 1 (wolframin)
WIPF1 WAS/WASL interacting protein family, member 1
XCL1 chemokine (C motif) ligand 1
XCL2 chemokine (C motif) ligand 2
XKR5 XK, Kell blood group complex subunit-related family, member 5
ZBTB49 zinc finger and BTB domain containing 49
ZHX1 zinc fingers and homeoboxes 1
ZMAT4 zinc finger, matrin-type 4
ZNF106 zinc finger protein 106
ZNF107 zinc finger protein 107
ZNF252P-AS1 ZNF252P antisense RNA 1
ZNF385B zinc finger protein 385B
ZNF441 zinc finger protein 441
ZNF721 zinc finger protein 721
ZNF845 zinc finger protein 845
ZNF91 zinc finger protein 91
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase