Sjogren's Syndrome Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A hypersensitivity reaction type II disease that involves attack of immune cells which destroy the exocrine glands that produce tears and saliva. (Human Disease Ontology, DOID_12894)
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Genes

99 genes associated with the Sjogren's Syndrome phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
AICDA activation-induced cytidine deaminase
APOE apolipoprotein E
BAK1 BCL2-antagonist/killer 1
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL2 B-cell CLL/lymphoma 2
BLK BLK proto-oncogene, Src family tyrosine kinase
BTLA B and T lymphocyte associated
CARD8 caspase recruitment domain family, member 8
CCL11 chemokine (C-C motif) ligand 11
CCL3L1 chemokine (C-C motif) ligand 3-like 1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR7 chemokine (C-C motif) receptor 7
CHRM3 cholinergic receptor, muscarinic 3
CHUK conserved helix-loop-helix ubiquitous kinase
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CXCR5 chemokine (C-X-C motif) receptor 5
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DGKQ diacylglycerol kinase, theta 110kDa
DNASE1 deoxyribonuclease I
EBF1 early B-cell factor 1
FAM167A family with sequence similarity 167, member A
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FLNB filamin B, beta
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
GTF2I general transcription factor IIi
GTF2IRD1 GTF2I repeat domain containing 1
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
HMHA1 histocompatibility (minor) HA-1
ICA1 islet cell autoantigen 1, 69kDa
IFNG interferon, gamma
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGK immunoglobulin kappa locus
IGKC immunoglobulin kappa constant
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL10 interleukin 10
IL12A interleukin 12A
IL13 interleukin 13
IL17A interleukin 17A
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL2 interleukin 2
IL21 interleukin 21
IL23R interleukin 23 receptor
IL4 interleukin 4
IL6 interleukin 6
IRAK1BP1 interleukin-1 receptor-associated kinase 1 binding protein 1
IRF5 interferon regulatory factor 5
ITSN2 intersectin 2
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR2DS3 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KIR2DS5 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
LOC100506023 uncharacterized LOC100506023
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
MBL2 mannose-binding lectin (protein C) 2, soluble
MMP9 matrix metallopeptidase 9
MYD88 myeloid differentiation primary response 88
NCR3 natural cytotoxicity triggering receptor 3
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
PHIP pleckstrin homology domain interacting protein
PKN1 protein kinase N1
PRDM1 PR domain containing 1, with ZNF domain
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTTG1 pituitary tumor-transforming 1
SLC25A40 solute carrier family 25, member 40
STAT4 signal transducer and activator of transcription 4
TANK TRAF family member-associated NFKB activator
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNIP1 TNFAIP3 interacting protein 1
TNPO3 transportin 3
TRB T cell receptor beta locus
TRBV16 T cell receptor beta variable 16 (gene/pseudogene)
TREX1 three prime repair exonuclease 1
TRIM21 tripartite motif containing 21