Silicosis Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles. (Human Disease Ontology, DOID_10325)
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Genes

27 genes associated with the Silicosis phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ATM ATM serine/threonine kinase
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR2 chemokine (C-X-C motif) receptor 2
EGF epidermal growth factor
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
GSTP1 glutathione S-transferase pi 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IL10 interleukin 10
IL11RA interleukin 11 receptor, alpha
IL12B interleukin 12B
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS2 nitric oxide synthase 2, inducible
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B