Senescence-Associated Secretory Phenotype (SASP) Gene Set

Dataset Reactome Pathways
Category structural or functional annotations
Type pathway
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-2559582
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Genes

75 proteins participating in the Senescence-Associated Secretory Phenotype (SASP) pathway from the Reactome Pathways dataset.

Symbol Name
ANAPC1 anaphase promoting complex subunit 1
ANAPC10 anaphase promoting complex subunit 10
ANAPC11 anaphase promoting complex subunit 11
ANAPC2 anaphase promoting complex subunit 2
ANAPC4 anaphase promoting complex subunit 4
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
CCNA1 cyclin A1
CCNA2 cyclin A2
CDC16 cell division cycle 16
CDC23 cell division cycle 23
CDC26 cell division cycle 26
CDC27 cell division cycle 27
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CXCL8 chemokine (C-X-C motif) ligand 8
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
H2AFB1 H2A histone family, member B1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
H2BFS H2B histone family, member S (pseudogene)
H3F3A H3 histone, family 3A
HIST1H2AB histone cluster 1, H2ab
HIST1H2AC histone cluster 1, H2ac
HIST1H2AD histone cluster 1, H2ad
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BA histone cluster 1, H2ba
HIST1H2BB histone cluster 1, H2bb
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BH histone cluster 1, H2bh
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BK histone cluster 1, H2bk
HIST1H2BL histone cluster 1, H2bl
HIST1H2BM histone cluster 1, H2bm
HIST1H2BN histone cluster 1, H2bn
HIST1H2BO histone cluster 1, H2bo
HIST1H3A histone cluster 1, H3a
HIST1H4A histone cluster 1, H4a
HIST2H2AA3 histone cluster 2, H2aa3
HIST2H2AC histone cluster 2, H2ac
HIST2H2BE histone cluster 2, H2be
HIST2H3A histone cluster 2, H3a
HIST3H2BB histone cluster 3, H2bb
IGFBP7 insulin-like growth factor binding protein 7
IL1A interleukin 1, alpha
IL6 interleukin 6
JUN jun proto-oncogene
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPS27A ribosomal protein S27a
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2C ubiquitin-conjugating enzyme E2C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2E1 ubiquitin-conjugating enzyme E2E 1