Sciatica Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Pain in the lower back and hip radiating in the distribution of the sciatic nerve. (Human Phenotype Ontology, HP_0011868)
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Genes

29 genes associated with the Sciatica phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ADRA1A adrenoceptor alpha 1A
ADRA2A adrenoceptor alpha 2A
ADRA2C adrenoceptor alpha 2C
BDNF brain-derived neurotrophic factor
CHRM1 cholinergic receptor, muscarinic 1
CNR1 cannabinoid receptor 1 (brain)
COL9A2 collagen, type IX, alpha 2
COMT catechol-O-methyltransferase
DRD2 dopamine receptor D2
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GCH1 GTP cyclohydrolase 1
GLRA1 glycine receptor, alpha 1
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IFNG interferon, gamma
IL10 interleukin 10
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
MMP1 matrix metallopeptidase 1
OPRM1 opioid receptor, mu 1
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
TAC1 tachykinin, precursor 1
TNF tumor necrosis factor