Schizophrenia Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness. (Human Disease Ontology, DOID_5419)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D012559
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Genes

260 genes/proteins associated with the disease Schizophrenia from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
ZNF565 zinc finger protein 565 2.88009
SCZD7 schizophrenia disorder 7 2.88009
SCZD8 schizophrenia disorder 8 2.88009
NRGN neurogranin (protein kinase C substrate, RC3) 2.88009
NRG3 neuregulin 3 2.88009
NRG1 neuregulin 1 2.88009
MAGEC1 melanoma antigen family C1 2.88009
SELENBP1 selenium binding protein 1 2.88009
VIPR2 vasoactive intestinal peptide receptor 2 2.88009
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.88009
SCZD6 schizophrenia disorder 6 2.88009
SCZD1 schizophrenia disorder 1 2.88009
SCZD3 schizophrenia disorder 3 2.88009
TP53 tumor protein p53 2.88009
PVALB parvalbumin 2.88009
TPH1 tryptophan hydroxylase 1 2.88009
OR4C46 olfactory receptor, family 4, subfamily C, member 46 2.88009
GRM3 glutamate receptor, metabotropic 3 2.88009
GRM2 glutamate receptor, metabotropic 2 2.88009
ZNF480 zinc finger protein 480 2.88009
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 2.88009
PGBD1 piggyBac transposable element derived 1 2.88009
DTNBP1 dystrobrevin binding protein 1 2.88009
NTNG2 netrin G2 2.88009
GSK3B glycogen synthase kinase 3 beta 2.88009
GSK3A glycogen synthase kinase 3 alpha 2.88009
ZNF530 zinc finger protein 530 2.88009
SCZD10 schizophrenia disorder 10 (periodic catatonia) 2.88009
DISC2 disrupted in schizophrenia 2 (non-protein coding) 2.88009
DISC1 disrupted in schizophrenia 1 2.88009
NTSR1 neurotensin receptor 1 (high affinity) 2.88009
GIF gastric intrinsic factor (vitamin B synthesis) 2.88009
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.88009
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.88009
APOL4 apolipoprotein L, 4 2.88009
APOL2 apolipoprotein L, 2 2.88009
NTNG1 netrin G1 2.88009
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 2.88009
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 2.88009
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 2.88009
GRIK5 glutamate receptor, ionotropic, kainate 5 2.88009
GRIK2 glutamate receptor, ionotropic, kainate 2 2.88009
DLG1 discs, large homolog 1 (Drosophila) 2.88009
NOS1 nitric oxide synthase 1 (neuronal) 2.88009
APOL1 apolipoprotein L, 1 2.88009
HCAR2 hydroxycarboxylic acid receptor 2 2.88009
DPYD dihydropyrimidine dehydrogenase 2.88009
SDF4 stromal cell derived factor 4 2.88009
CNTNAP2 contactin associated protein-like 2 2.88009
PRODH proline dehydrogenase (oxidase) 1 2.88009
RTN4 reticulon 4 2.88009
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 2.88009
CHL1 cell adhesion molecule L1-like 2.88009
RTN4R reticulon 4 receptor 2.88009
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 2.88009
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 2.88009
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.88009
OXTR oxytocin receptor 2.88009
FGFR1 fibroblast growth factor receptor 1 2.88009
PML promyelocytic leukemia 2.88009
EDEM2 ER degradation enhancer, mannosidase alpha-like 2 2.88009
CCL2 chemokine (C-C motif) ligand 2 2.88009
SCZD2 schizophrenia disorder 2 2.88009
SBNO1 strawberry notch homolog 1 (Drosophila) 2.88009
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.88009
CASP4 caspase 4, apoptosis-related cysteine peptidase 2.88009
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae) 2.88009
EIF5 eukaryotic translation initiation factor 5 2.88009
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 2.88009
CELF2 CUGBP, Elav-like family member 2 2.88009
BDNF brain-derived neurotrophic factor 2.88009
SCZD13 schizophrenia 13 2.88009
PLXNA2 plexin A2 2.88009
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.88009
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.88009
ZNF804A zinc finger protein 804A 2.88009
PHB prohibitin 2.88009
GPR153 G protein-coupled receptor 153 2.88009
SLC26A7 solute carrier family 26 (anion exchanger), member 7 2.88009
SP4 Sp4 transcription factor 2.88009
SCZD11 Schizophrenia susceptibility locus, chromosome 10q-related 2.88009
NRXN1 neurexin 1 2.88009
IL6R interleukin 6 receptor 2.88009
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.88009
IL2RA interleukin 2 receptor, alpha 2.88009
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 2.88009
SCZD14 schizophrenia, susceptibility to, 14 2.88009
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 2.88009
AVP arginine vasopressin 2.88009
CHD4 chromodomain helicase DNA binding protein 4 2.88009
CPLX1 complexin 1 2.88009
SLC26A8 solute carrier family 26 (anion exchanger), member 8 2.88009
IL1B interleukin 1, beta 2.88009
KDM2B lysine (K)-specific demethylase 2B 2.88009
SPATA5 spermatogenesis associated 5 2.88009
FAM3D family with sequence similarity 3, member D 2.88009
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 2.88009
LRP1 low density lipoprotein receptor-related protein 1 2.88009
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 2.88009
TAAR6 trace amine associated receptor 6 2.88009
AHI1 Abelson helper integration site 1 2.88009
CP ceruloplasmin (ferroxidase) 2.88009
RELN reelin 2.88009
RB1CC1 RB1-inducible coiled-coil 1 2.88009
TEKT5 tektin 5 2.88009
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 2.88009
CCDC108 coiled-coil domain containing 108 2.88009
NRIP1 nuclear receptor interacting protein 1 2.88009
MIR137 microRNA 137 2.88009
ALS2CL ALS2 C-terminal like 2.88009
PCM1 pericentriolar material 1 2.88009
IL6 interleukin 6 2.88009
NTF3 neurotrophin 3 2.88009
MAOB monoamine oxidase B 2.88009
TRAK1 trafficking protein, kinesin binding 1 2.88009
DAOA D-amino acid oxidase activator 2.88009
CPLX2 complexin 2 2.88009
COL3A1 collagen, type III, alpha 1 2.88009
CLINT1 clathrin interactor 1 2.88009
CNR1 cannabinoid receptor 1 (brain) 2.88009
CCDC137 coiled-coil domain containing 137 2.88009
SYP synaptophysin 2.88009
PDE4B phosphodiesterase 4B, cAMP-specific 2.88009
BTG1 B-cell translocation gene 1, anti-proliferative 2.88009
MT-ND4 NADH dehydrogenase, subunit 4 (complex I) 2.88009
WDR11 WD repeat domain 11 2.88009
PLCL2 phospholipase C-like 2 2.88009
KDR kinase insert domain receptor 2.88009
LAMA1 laminin, alpha 1 2.88009
LAMA2 laminin, alpha 2 2.88009
FASTKD5 FAST kinase domains 5 2.88009
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 2.88009
RGS9 regulator of G-protein signaling 9 2.88009
THBS1 thrombospondin 1 2.88009
RGS4 regulator of G-protein signaling 4 2.88009
CAMK2B calcium/calmodulin-dependent protein kinase II beta 2.88009
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 2.88009
APOE apolipoprotein E 2.88009
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 2.88009
NKAPL NFKB activating protein-like 2.88009
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.88009
SCZD12 schizophrenia 12 2.88009
HRH1 histamine receptor H1 2.88009
RGS12 regulator of G-protein signaling 12 2.88009
SRSF1 serine/arginine-rich splicing factor 1 2.88009
SYN2 synapsin II 2.88009
HP haptoglobin 2.88009
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 2.88009
TRRAP transformation/transcription domain-associated protein 2.88009
KPNA1 karyopherin alpha 1 (importin alpha 5) 2.88009
TSPAN18 tetraspanin 18 2.88009
MTOR mechanistic target of rapamycin (serine/threonine kinase) 2.88009
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.88009
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2.88009
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 2.88009
MET MET proto-oncogene, receptor tyrosine kinase 2.88009
ESAM endothelial cell adhesion molecule 2.88009
ADCY7 adenylate cyclase 7 2.88009
SAP30BP SAP30 binding protein 2.88009
TNF tumor necrosis factor 2.88009
DRD1 dopamine receptor D1 2.88009
DRD3 dopamine receptor D3 2.88009
DRD2 dopamine receptor D2 2.88009
DRD4 dopamine receptor D4 2.88009
ACOT6 acyl-CoA thioesterase 6 2.88009
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 2.88009
DAO D-amino-acid oxidase 2.88009
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 2.88009
COMT catechol-O-methyltransferase 2.88009
HINT1 histidine triad nucleotide binding protein 1 2.88009
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.88009
KLF12 Kruppel-like factor 12 2.88009
TAC1 tachykinin, precursor 1 2.88009
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 2.88009
DGCR2 DiGeorge syndrome critical region gene 2 2.88009
PRL prolactin 2.21213
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 2.0356
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.96935
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.87742
FOS FBJ murine osteosarcoma viral oncogene homolog 1.80567
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.71606
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.71441
SOD1 superoxide dismutase 1, soluble 1.60547
NPY neuropeptide Y 1.59451
CAT catalase 1.59125
NUPR1 nuclear protein, transcriptional regulator, 1 1.57641
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.56312
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 1.54523
CRH corticotropin releasing hormone 1.53382
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 1.50146
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.49148
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.48761
TH tyrosine hydroxylase 1.46304
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.45247
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.43755
RGS2 regulator of G-protein signaling 2 1.39952
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.39422
ARC activity-regulated cytoskeleton-associated protein 1.3793
EGR1 early growth response 1 1.3793
CREB1 cAMP responsive element binding protein 1 1.37619
BAX BCL2-associated X protein 1.36047
TAGLN transgelin 1.35647
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.35328
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 1.35155
GFAP glial fibrillary acidic protein 1.34782
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.34606
MAOA monoamine oxidase A 1.33464
JUN jun proto-oncogene 1.32162
DUSP1 dual specificity phosphatase 1 1.31837
EFNA1 ephrin-A1 1.28765
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.27533
MAPK1 mitogen-activated protein kinase 1 1.27286
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.27132
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.26483
EFNA2 ephrin-A2 1.23584
MAPK3 mitogen-activated protein kinase 3 1.23584
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.23584
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.22048
INS insulin 1.21695
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.20848
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.20719
BCL2 B-cell CLL/lymphoma 2 1.20687
CCND1 cyclin D1 1.18159
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.17134
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.17101
MAP2 microtubule-associated protein 2 1.169
PLP1 proteolipid protein 1 1.16866
C10ORF10 chromosome 10 open reading frame 10 1.16236
MBP myelin basic protein 1.16137
ATF3 activating transcription factor 3 1.1607
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.1529
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.13758
INHBE inhibin, beta E 1.13724
LDLR low density lipoprotein receptor 1.13484
MAPK8 mitogen-activated protein kinase 8 1.12906
HOMER1 homer scaffolding protein 1 1.12737
VEGFA vascular endothelial growth factor A 1.12323
SREBF2 sterol regulatory element binding transcription factor 2 1.11775
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.10353
PENK proenkephalin 1.09998
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.09857
FNDC4 fibronectin type III domain containing 4 1.09226
CDK5 cyclin-dependent kinase 5 1.09119
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.09083
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.08055
FABP1 fatty acid binding protein 1, liver 1.07732
CTSK cathepsin K 1.0734
FAS Fas cell surface death receptor 1.07057
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.05793
LRRN1 leucine rich repeat neuronal 1 1.0561
NGFR nerve growth factor receptor 1.04868
OPRM1 opioid receptor, mu 1 1.04757
GNAS GNAS complex locus 1.04314
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.03641
CLTB clathrin, light chain B 1.03084
MAL mal, T-cell differentiation protein 1.02634
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 1.0241
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.02077
JUND jun D proto-oncogene 1.01549
LEP leptin 1.01212