SC-560-6865 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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193 genes differentially expressed following the SC-560-6865 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ACTA2 actin, alpha 2, smooth muscle, aorta
AIM1L absent in melanoma 1-like
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
APOL6 apolipoprotein L, 6
ATP10D ATPase, class V, type 10D
BCL2L1 BCL2-like 1
BCOR BCL6 corepressor
BDNF brain-derived neurotrophic factor
BEX4 brain expressed, X-linked 4
BICD1 bicaudal D homolog 1 (Drosophila)
BTG2 BTG family, member 2
BTN2A3P butyrophilin, subfamily 2, member A3, pseudogene
C14ORF79 chromosome 14 open reading frame 79
C1ORF54 chromosome 1 open reading frame 54
C9ORF116 chromosome 9 open reading frame 116
CDC14A cell division cycle 14A
CDC40 cell division cycle 40
COL21A1 collagen, type XXI, alpha 1
CUL4B cullin 4B
CXCL3 chemokine (C-X-C motif) ligand 3
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DAGLA diacylglycerol lipase, alpha
DALRD3 DALR anticodon binding domain containing 3
DENND2A DENN/MADD domain containing 2A
DVL2 dishevelled segment polarity protein 2
EPN1 epsin 1
EXT1 exostosin glycosyltransferase 1
FAM174B family with sequence similarity 174, member B
FHL1 four and a half LIM domains 1
FOXE1 forkhead box E1
FRS3 fibroblast growth factor receptor substrate 3
FSD1 fibronectin type III and SPRY domain containing 1
GATA3 GATA binding protein 3
GBX2 gastrulation brain homeobox 2
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GMEB2 glucocorticoid modulatory element binding protein 2
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPATCH2L G patch domain containing 2-like
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HDAC5 histone deacetylase 5
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H2AJ histone cluster 1, H2aj
HIST1H3G histone cluster 1, H3g
HSPA4 heat shock 70kDa protein 4
IGF1R insulin-like growth factor 1 receptor
IL15RA interleukin 15 receptor, alpha
ITPKC inositol-trisphosphate 3-kinase C
LRP6 low density lipoprotein receptor-related protein 6
MAPK7 mitogen-activated protein kinase 7
MCM4 minichromosome maintenance complex component 4
MET MET proto-oncogene, receptor tyrosine kinase
MOB3B MOB kinase activator 3B
MYOZ3 myozenin 3
NDNF neuron-derived neurotrophic factor
NDP Norrie disease (pseudoglioma)
NFYC nuclear transcription factor Y, gamma
NNT nicotinamide nucleotide transhydrogenase
NPR3 natriuretic peptide receptor 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
PAPPA2 pappalysin 2
PDPK1 3-phosphoinositide dependent protein kinase 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
PRICKLE3 prickle homolog 3 (Drosophila)
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PTBP3 polypyrimidine tract binding protein 3
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RBM34 RNA binding motif protein 34
REEP2 receptor accessory protein 2
RNF146 ring finger protein 146
SBF1 SET binding factor 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SH2B1 SH2B adaptor protein 1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SOX15 SRY (sex determining region Y)-box 15
SPN sialophorin
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
STIP1 stress-induced phosphoprotein 1
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TAOK2 TAO kinase 2
TDRD3 tudor domain containing 3
TFDP1 transcription factor Dp-1
TM2D1 TM2 domain containing 1
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TPM2 tropomyosin 2 (beta)
TRIO trio Rho guanine nucleotide exchange factor
TUSC3 tumor suppressor candidate 3
VIPR2 vasoactive intestinal peptide receptor 2
WDR1 WD repeat domain 1
WNT7A wingless-type MMTV integration site family, member 7A
YEATS4 YEATS domain containing 4
ZC3H7B zinc finger CCCH-type containing 7B
ZNF174 zinc finger protein 174

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ACOT8 acyl-CoA thioesterase 8
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
ADAP2 ArfGAP with dual PH domains 2
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
ARID5A AT rich interactive domain 5A (MRF1-like)
ARSA arylsulfatase A
ATP4B ATPase, H+/K+ exchanging, beta polypeptide
AVPR1B arginine vasopressin receptor 1B
BCAS3 breast carcinoma amplified sequence 3
BFSP1 beaded filament structural protein 1, filensin
C3 complement component 3
C5ORF45 chromosome 5 open reading frame 45
C7ORF43 chromosome 7 open reading frame 43
C8B complement component 8, beta polypeptide
CCDC88C coiled-coil domain containing 88C
CCDC9 coiled-coil domain containing 9
CCL22 chemokine (C-C motif) ligand 22
CD300C CD300c molecule
CDK20 cyclin-dependent kinase 20
CFAP44 cilia and flagella associated protein 44
CGREF1 cell growth regulator with EF-hand domain 1
CLCN6 chloride channel, voltage-sensitive 6
CLDN15 claudin 15
CNPY4 canopy FGF signaling regulator 4
CNTFR ciliary neurotrophic factor receptor
CSRNP3 cysteine-serine-rich nuclear protein 3
CTF1 cardiotrophin 1
CXORF21 chromosome X open reading frame 21
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EGFL7 EGF-like-domain, multiple 7
ELP3 elongator acetyltransferase complex subunit 3
EPHA4 EPH receptor A4
ERCC2 excision repair cross-complementation group 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM186A family with sequence similarity 186, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXC1 forkhead box C1
GUCA1B guanylate cyclase activator 1B (retina)
HDAC7 histone deacetylase 7
HLA-DMA major histocompatibility complex, class II, DM alpha
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IL17RA interleukin 17 receptor A
IMPACT impact RWD domain protein
KIAA1324 KIAA1324
KLK1 kallikrein 1
MEOX1 mesenchyme homeobox 1
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MILR1 mast cell immunoglobulin-like receptor 1
MIP major intrinsic protein of lens fiber
MUTYH mutY homolog
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NME5 NME/NM23 family member 5
OSGIN1 oxidative stress induced growth inhibitor 1
OSMR oncostatin M receptor
PAQR5 progestin and adipoQ receptor family member V
PARP3 poly (ADP-ribose) polymerase family, member 3
PARP6 poly (ADP-ribose) polymerase family, member 6
PHOX2B paired-like homeobox 2b
PPT2 palmitoyl-protein thioesterase 2
PRR15L proline rich 15-like
PTPRE protein tyrosine phosphatase, receptor type, E
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RWDD2A RWD domain containing 2A
S100A3 S100 calcium binding protein A3
SCN1B sodium channel, voltage gated, type I beta subunit
SECISBP2 SECIS binding protein 2
SELPLG selectin P ligand
SH3BGR SH3 domain binding glutamate-rich protein
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SPINK1 serine peptidase inhibitor, Kazal type 1
SPTBN2 spectrin, beta, non-erythrocytic 2
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TBX19 T-box 19
TESPA1 thymocyte expressed, positive selection associated 1
TIMP4 TIMP metallopeptidase inhibitor 4
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMPRSS6 transmembrane protease, serine 6
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TRPV6 transient receptor potential cation channel, subfamily V, member 6
WDR4 WD repeat domain 4
ZFP69B ZFP69 zinc finger protein B
ZNF219 zinc finger protein 219
ZNF671 zinc finger protein 671
ZNF747 zinc finger protein 747