SB-203580-7066 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the SB-203580-7066 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACACA acetyl-CoA carboxylase alpha
ADGRG2 adhesion G protein-coupled receptor G2
AHI1 Abelson helper integration site 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APP amyloid beta (A4) precursor protein
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARL2BP ADP-ribosylation factor-like 2 binding protein
ARMC6 armadillo repeat containing 6
ATF6B activating transcription factor 6 beta
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BMP1 bone morphogenetic protein 1
C17ORF53 chromosome 17 open reading frame 53
CDC25C cell division cycle 25C
CDK13 cyclin-dependent kinase 13
COL4A6 collagen, type IV, alpha 6
CPT1A carnitine palmitoyltransferase 1A (liver)
CREB3L1 cAMP responsive element binding protein 3-like 1
CROCC ciliary rootlet coiled-coil, rootletin
CTAGE5 CTAGE family, member 5
CTSZ cathepsin Z
DENND2A DENN/MADD domain containing 2A
ECM1 extracellular matrix protein 1
EDIL3 EGF-like repeats and discoidin I-like domains 3
EFNA3 ephrin-A3
EPHX2 epoxide hydrolase 2, cytoplasmic
EPS8L1 EPS8-like 1
FAM13A family with sequence similarity 13, member A
FBLN1 fibulin 1
FH fumarate hydratase
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FYB FYN binding protein
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HN1L hematological and neurological expressed 1-like
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
HOXB5 homeobox B5
HSDL2 hydroxysteroid dehydrogenase like 2
HTT huntingtin
IL1RAP interleukin 1 receptor accessory protein
ITK IL2-inducible T-cell kinase
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KRIT1 KRIT1, ankyrin repeat containing
LEFTY1 left-right determination factor 1
LIMK1 LIM domain kinase 1
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRRC40 leucine rich repeat containing 40
LRRK1 leucine-rich repeat kinase 1
MCC mutated in colorectal cancers
MEF2A myocyte enhancer factor 2A
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MIP major intrinsic protein of lens fiber
MLH3 mutL homolog 3
MMP14 matrix metallopeptidase 14 (membrane-inserted)
NAAA N-acylethanolamine acid amidase
NDE1 nudE neurodevelopment protein 1
NF2 neurofibromin 2 (merlin)
NKIRAS2 NFKB inhibitor interacting Ras-like 2
PDGFB platelet-derived growth factor beta polypeptide
PEX1 peroxisomal biogenesis factor 1
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKNOX1 PBX/knotted 1 homeobox 1
PLXNA1 plexin A1
POMT2 protein-O-mannosyltransferase 2
PPARD peroxisome proliferator-activated receptor delta
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRR4 proline rich 4 (lacrimal)
PRSS8 protease, serine, 8
RAB27B RAB27B, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RAB3B RAB3B, member RAS oncogene family
RIMS3 regulating synaptic membrane exocytosis 3
RNF122 ring finger protein 122
RNF216 ring finger protein 216
RREB1 ras responsive element binding protein 1
SARM1 sterile alpha and TIR motif containing 1
SCAMP5 secretory carrier membrane protein 5
SCAPER S-phase cyclin A-associated protein in the ER
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SPPL2B signal peptide peptidase like 2B
SQSTM1 sequestosome 1
TAGLN3 transgelin 3
TESK2 testis-specific kinase 2
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TOB2 transducer of ERBB2, 2
TTC12 tetratricopeptide repeat domain 12
TTLL5 tubulin tyrosine ligase-like family member 5
USP20 ubiquitin specific peptidase 20
VCAN versican
WDFY3 WD repeat and FYVE domain containing 3
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
YIPF4 Yip1 domain family, member 4
ZBTB43 zinc finger and BTB domain containing 43
ZNF205 zinc finger protein 205
ZNF43 zinc finger protein 43
ZNF552 zinc finger protein 552

decreased expression

Symbol Name
AAR2 AAR2 splicing factor homolog (S. cerevisiae)
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ATF7IP2 activating transcription factor 7 interacting protein 2
ATP7B ATPase, Cu++ transporting, beta polypeptide
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BBS7 Bardet-Biedl syndrome 7
C16ORF59 chromosome 16 open reading frame 59
C17ORF70 chromosome 17 open reading frame 70
C8ORF44 chromosome 8 open reading frame 44
C9ORF91 chromosome 9 open reading frame 91
CARD8 caspase recruitment domain family, member 8
CASZ1 castor zinc finger 1
CCNJL cyclin J-like
CD82 CD82 molecule
CDT1 chromatin licensing and DNA replication factor 1
CEP112 centrosomal protein 112kDa
CHKB choline kinase beta
CLCN6 chloride channel, voltage-sensitive 6
CLDN11 claudin 11
CLDN14 claudin 14
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CROT carnitine O-octanoyltransferase
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DENND5B DENN/MADD domain containing 5B
EFCAB2 EF-hand calcium binding domain 2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERN2 endoplasmic reticulum to nucleus signaling 2
F3 coagulation factor III (thromboplastin, tissue factor)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
GRB7 growth factor receptor-bound protein 7
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HLX H2.0-like homeobox
HPS6 Hermansky-Pudlak syndrome 6
HYAL3 hyaluronoglucosaminidase 3
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IPO13 importin 13
IRAK4 interleukin-1 receptor-associated kinase 4
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0319L KIAA0319-like
KIAA0513 KIAA0513
KIAA0754 KIAA0754
KLHL12 kelch-like family member 12
LMBR1L limb development membrane protein 1-like
LYPD3 LY6/PLAUR domain containing 3
MAGEA3 melanoma antigen family A3
MAPK12 mitogen-activated protein kinase 12
MFSD11 major facilitator superfamily domain containing 11
MGA MGA, MAX dimerization protein
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MMP13 matrix metallopeptidase 13
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MTMR11 myotubularin related protein 11
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NINJ1 ninjurin 1
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3
OSTF1 osteoclast stimulating factor 1
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PECR peroxisomal trans-2-enoyl-CoA reductase
PENK proenkephalin
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNF31 ring finger protein 31
RPP25 ribonuclease P/MRP 25kDa subunit
SAMD9 sterile alpha motif domain containing 9
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SEPP1 selenoprotein P, plasma, 1
SH3GL2 SH3-domain GRB2-like 2
SLC35F6 solute carrier family 35, member F6
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLITRK5 SLIT and NTRK-like family, member 5
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
SNHG20 small nucleolar RNA host gene 20
SPIDR scaffolding protein involved in DNA repair
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SUGP1 SURP and G patch domain containing 1
TCTN1 tectonic family member 1
TEP1 telomerase-associated protein 1
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM38B transmembrane protein 38B
TNRC6B trinucleotide repeat containing 6B
TTLL7 tubulin tyrosine ligase-like family member 7
TUBA3C tubulin, alpha 3c
UNC93B1 unc-93 homolog B1 (C. elegans)
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
YEATS4 YEATS domain containing 4
ZBTB22 zinc finger and BTB domain containing 22
ZFP69B ZFP69 zinc finger protein B
ZNF226 zinc finger protein 226
ZNF280D zinc finger protein 280D
ZNF286A zinc finger protein 286A
ZNF358 zinc finger protein 358
ZNF721 zinc finger protein 721