SB-203580-7061 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the SB-203580-7061 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADAP1 ArfGAP with dual PH domains 1
ADCK2 aarF domain containing kinase 2
ADRBK1 adrenergic, beta, receptor kinase 1
AKAP17A A kinase (PRKA) anchor protein 17A
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ASB9 ankyrin repeat and SOCS box containing 9
C2ORF68 chromosome 2 open reading frame 68
CACFD1 calcium channel flower domain containing 1
CC2D1A coiled-coil and C2 domain containing 1A
CHST10 carbohydrate sulfotransferase 10
CRY2 cryptochrome circadian clock 2
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DUSP6 dual specificity phosphatase 6
ELF4 E74-like factor 4 (ets domain transcription factor)
ESRRA estrogen-related receptor alpha
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM65A family with sequence similarity 65, member A
FHL1 four and a half LIM domains 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FOXO1 forkhead box O1
FSCN1 fascin actin-bundling protein 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GLB1L galactosidase, beta 1-like
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIC2 hypermethylated in cancer 2
HLA-DMA major histocompatibility complex, class II, DM alpha
HOMER3 homer scaffolding protein 3
HPN hepsin
IFT122 intraflagellar transport 122
IL27RA interleukin 27 receptor, alpha
IL4R interleukin 4 receptor
IRF5 interferon regulatory factor 5
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KAT2A K(lysine) acetyltransferase 2A
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KIAA0930 KIAA0930
KLHDC4 kelch domain containing 4
KPNB1 karyopherin (importin) beta 1
KRT75 keratin 75, type II
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTBP4 latent transforming growth factor beta binding protein 4
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MMP19 matrix metallopeptidase 19
NCOA2 nuclear receptor coactivator 2
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NPR2 natriuretic peptide receptor 2
OLFML3 olfactomedin-like 3
PDLIM7 PDZ and LIM domain 7 (enigma)
PHLDB1 pleckstrin homology-like domain, family B, member 1
PLCD1 phospholipase C, delta 1
POFUT1 protein O-fucosyltransferase 1
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRLR prolactin receptor
RAB3A RAB3A, member RAS oncogene family
RER1 retention in endoplasmic reticulum sorting receptor 1
RGS12 regulator of G-protein signaling 12
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF126P1 ring finger protein 126 pseudogene 1
RPAP1 RNA polymerase II associated protein 1
SLC38A7 solute carrier family 38, member 7
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
SPPL2B signal peptide peptidase like 2B
SSPN sarcospan
ST5 suppression of tumorigenicity 5
SYNGR1 synaptogyrin 1
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCTN1 tectonic family member 1
TEX264 testis expressed 264
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TLN2 talin 2
TMC5 transmembrane channel-like 5
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSFM Ts translation elongation factor, mitochondrial
TULP3 tubby like protein 3
UBTD1 ubiquitin domain containing 1
UNC93B1 unc-93 homolog B1 (C. elegans)
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
USP20 ubiquitin specific peptidase 20
USP22 ubiquitin specific peptidase 22
USP34 ubiquitin specific peptidase 34
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VPS9D1 VPS9 domain containing 1
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZFAND6 zinc finger, AN1-type domain 6
ZNF117 zinc finger protein 117
ZNF230 zinc finger protein 230
ZNF500 zinc finger protein 500

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABHD17B abhydrolase domain containing 17B
ADCY7 adenylate cyclase 7
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ALS2CL ALS2 C-terminal like
AMPD1 adenosine monophosphate deaminase 1
ANP32A-IT1 ANP32A intronic transcript 1
APOLD1 apolipoprotein L domain containing 1
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BAGE B melanoma antigen
C7ORF43 chromosome 7 open reading frame 43
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CCDC121 coiled-coil domain containing 121
CCDC68 coiled-coil domain containing 68
CD302 CD302 molecule
CD80 CD80 molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CDH18 cadherin 18, type 2
CDK6 cyclin-dependent kinase 6
CENPQ centromere protein Q
CFAP44 cilia and flagella associated protein 44
CYB5R1 cytochrome b5 reductase 1
CYBA cytochrome b-245, alpha polypeptide
DEPDC5 DEP domain containing 5
DGAT1 diacylglycerol O-acyltransferase 1
DMTN dematin actin binding protein
DNM1 dynamin 1
EFCAB2 EF-hand calcium binding domain 2
EGFL7 EGF-like-domain, multiple 7
ERN1 endoplasmic reticulum to nucleus signaling 1
FADS2 fatty acid desaturase 2
FGF13 fibroblast growth factor 13
FKBP5 FK506 binding protein 5
FRMD1 FERM domain containing 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HDAC11 histone deacetylase 11
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HSPA1L heat shock 70kDa protein 1-like
IGLV1-44 immunoglobulin lambda variable 1-44
JMJD4 jumonji domain containing 4
KLHL25 kelch-like family member 25
LARP6 La ribonucleoprotein domain family, member 6
LMBR1L limb development membrane protein 1-like
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGEA5 melanoma antigen family A5
MORN1 MORN repeat containing 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MVP major vault protein
NEK11 NIMA-related kinase 11
OSMR oncostatin M receptor
PACS1 phosphofurin acidic cluster sorting protein 1
PCDHGB5 protocadherin gamma subfamily B, 5
PDE9A phosphodiesterase 9A
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PITX2 paired-like homeodomain 2
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PNRC1 proline-rich nuclear receptor coactivator 1
POLL polymerase (DNA directed), lambda
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTPRS protein tyrosine phosphatase, receptor type, S
PVRL3 poliovirus receptor-related 3
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB40C RAB40C, member RAS oncogene family
SAMHD1 SAM domain and HD domain 1
SAYSD1 SAYSVFN motif domain containing 1
SEPHS2 selenophosphate synthetase 2
SERTAD3 SERTA domain containing 3
SH2D3A SH2 domain containing 3A
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC17A2 solute carrier family 17, member 2
SP1 Sp1 transcription factor
STAG3 stromal antigen 3
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
SUN2 Sad1 and UNC84 domain containing 2
SYCP2 synaptonemal complex protein 2
SYNC syncoilin, intermediate filament protein
TMEM242 transmembrane protein 242
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAPPC11 trafficking protein particle complex 11
TRDMT1 tRNA aspartic acid methyltransferase 1
TRIM36 tripartite motif containing 36
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
WLS wntless Wnt ligand secretion mediator
WNT2 wingless-type MMTV integration site family member 2
ZNF10 zinc finger protein 10
ZNF137P zinc finger protein 137, pseudogene