SB-203580-6899 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the SB-203580-6899 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ALS2CL ALS2 C-terminal like
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCAS1 breast carcinoma amplified sequence 1
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
C17ORF53 chromosome 17 open reading frame 53
C2CD2 C2 calcium-dependent domain containing 2
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCHCR1 coiled-coil alpha-helical rod protein 1
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CHMP1B charged multivesicular body protein 1B
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
DEGS1 delta(4)-desaturase, sphingolipid 1
DNM2 dynamin 2
DXO decapping exoribonuclease
EDNRA endothelin receptor type A
EML1 echinoderm microtubule associated protein like 1
ETV5 ets variant 5
F11R F11 receptor
FBXO5 F-box protein 5
FPGT fucose-1-phosphate guanylyltransferase
FXR2 fragile X mental retardation, autosomal homolog 2
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GTDC1 glycosyltransferase-like domain containing 1
ICOSLG inducible T-cell co-stimulator ligand
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
INADL InaD-like (Drosophila)
ING1 inhibitor of growth family, member 1
IRF2 interferon regulatory factor 2
ITM2B integral membrane protein 2B
KIAA0895 KIAA0895
KPNA6 karyopherin alpha 6 (importin alpha 7)
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LOC647070 uncharacterized LOC647070
LRRC14 leucine rich repeat containing 14
LRRC41 leucine rich repeat containing 41
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY6D lymphocyte antigen 6 complex, locus D
LYPD1 LY6/PLAUR domain containing 1
MAP2K3 mitogen-activated protein kinase kinase 3
MAPK11 mitogen-activated protein kinase 11
MCM3AP minichromosome maintenance complex component 3 associated protein
METTL8 methyltransferase like 8
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MXD4 MAX dimerization protein 4
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEK11 NIMA-related kinase 11
NF2 neurofibromin 2 (merlin)
NFYA nuclear transcription factor Y, alpha
NPTX1 neuronal pentraxin I
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUMA1 nuclear mitotic apparatus protein 1
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OGFR opioid growth factor receptor
ORAI2 ORAI calcium release-activated calcium modulator 2
OVOL2 ovo-like zinc finger 2
PACS1 phosphofurin acidic cluster sorting protein 1
PC pyruvate carboxylase
PLAGL1 pleiomorphic adenoma gene-like 1
PVR poliovirus receptor
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RANBP1 RAN binding protein 1
RPAP1 RNA polymerase II associated protein 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
S100A8 S100 calcium binding protein A8
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SH2B1 SH2B adaptor protein 1
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SOD2 superoxide dismutase 2, mitochondrial
SPIDR scaffolding protein involved in DNA repair
SRSF8 serine/arginine-rich splicing factor 8
STK19 serine/threonine kinase 19
SUMO1 small ubiquitin-like modifier 1
TBC1D4 TBC1 domain family, member 4
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
THBS1 thrombospondin 1
TM2D1 TM2 domain containing 1
TP53I11 tumor protein p53 inducible protein 11
TRIM23 tripartite motif containing 23
TSPAN9 tetraspanin 9
TTC38 tetratricopeptide repeat domain 38
TWF2 twinfilin actin binding protein 2
USP48 ubiquitin specific peptidase 48
VAC14 Vac14 homolog (S. cerevisiae)
VPS9D1 VPS9 domain containing 1
ZC3H7B zinc finger CCCH-type containing 7B
ZNF174 zinc finger protein 174

decreased expression

Symbol Name
ACVR2A activin A receptor, type IIA
ADGRE5 adhesion G protein-coupled receptor E5
ADGRG2 adhesion G protein-coupled receptor G2
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ANKHD1 ankyrin repeat and KH domain containing 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BEX4 brain expressed, X-linked 4
BPGM 2,3-bisphosphoglycerate mutase
C1ORF105 chromosome 1 open reading frame 105
C1ORF54 chromosome 1 open reading frame 54
C2ORF44 chromosome 2 open reading frame 44
CAPG capping protein (actin filament), gelsolin-like
CDK3 cyclin-dependent kinase 3
CENPO centromere protein O
CEP290 centrosomal protein 290kDa
CLGN calmegin
CLSPN claspin
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CNR2 cannabinoid receptor 2 (macrophage)
CRYBB2P1 crystallin, beta B2 pseudogene 1
CUZD1 CUB and zona pellucida-like domains 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DESI1 desumoylating isopeptidase 1
DET1 de-etiolated homolog 1 (Arabidopsis)
DGAT1 diacylglycerol O-acyltransferase 1
DMTN dematin actin binding protein
DUSP2 dual specificity phosphatase 2
DUSP8 dual specificity phosphatase 8
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ETV6 ets variant 6
EXD3 exonuclease 3'-5' domain containing 3
EXTL3 exostosin-like glycosyltransferase 3
FAM46C family with sequence similarity 46, member C
FAM76A family with sequence similarity 76, member A
FGL1 fibrinogen-like 1
FLT4 fms-related tyrosine kinase 4
FRMPD1 FERM and PDZ domain containing 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GADD45G growth arrest and DNA-damage-inducible, gamma
GAMT guanidinoacetate N-methyltransferase
GBP2 guanylate binding protein 2, interferon-inducible
GDAP1 ganglioside induced differentiation associated protein 1
GMEB1 glucocorticoid modulatory element binding protein 1
GPR68 G protein-coupled receptor 68
GRM4 glutamate receptor, metabotropic 4
GTPBP2 GTP binding protein 2
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXC11 homeobox C11
HYAL1 hyaluronoglucosaminidase 1
INE1 inactivation escape 1 (non-protein coding)
INPP1 inositol polyphosphate-1-phosphatase
IQSEC2 IQ motif and Sec7 domain 2
KLHL28 kelch-like family member 28
LHX1 LIM homeobox 1
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MTA2 metastasis associated 1 family, member 2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NRTN neurturin
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PADI1 peptidyl arginine deiminase, type I
PARP12 poly (ADP-ribose) polymerase family, member 12
PLCD1 phospholipase C, delta 1
PORCN porcupine homolog (Drosophila)
PPT2 palmitoyl-protein thioesterase 2
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PTPRM protein tyrosine phosphatase, receptor type, M
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIN2 Ras and Rab interactor 2
RNF39 ring finger protein 39
SCNN1B sodium channel, non voltage gated 1 beta subunit
SKA1 spindle and kinetochore associated complex subunit 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SND1-IT1 SND1 intronic transcript 1
SPON2 spondin 2, extracellular matrix protein
SREK1IP1 SREK1-interacting protein 1
STRA6 stimulated by retinoic acid 6
TAC3 tachykinin 3
TBC1D17 TBC1 domain family, member 17
TEP1 telomerase-associated protein 1
TGFB3 transforming growth factor, beta 3
TIGD6 tigger transposable element derived 6
TRPM8 transient receptor potential cation channel, subfamily M, member 8
TUBB1 tubulin, beta 1 class VI
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBTD1 ubiquitin domain containing 1
USP19 ubiquitin specific peptidase 19
XYLT1 xylosyltransferase I
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF205 zinc finger protein 205
ZNF506 zinc finger protein 506
ZNF552 zinc finger protein 552