SB-203580-6894 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the SB-203580-6894 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALOXE3 arachidonate lipoxygenase 3
APOE apolipoprotein E
APOL3 apolipoprotein L, 3
APP amyloid beta (A4) precursor protein
ARHGAP26 Rho GTPase activating protein 26
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BCL2 B-cell CLL/lymphoma 2
C1ORF54 chromosome 1 open reading frame 54
CA5B carbonic anhydrase VB, mitochondrial
CACFD1 calcium channel flower domain containing 1
CCDC57 coiled-coil domain containing 57
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD52 CD52 molecule
CENPQ centromere protein Q
CERS4 ceramide synthase 4
CFAP69 cilia and flagella associated protein 69
CLMN calmin (calponin-like, transmembrane)
CRLF1 cytokine receptor-like factor 1
CUL3 cullin 3
DCAKD dephospho-CoA kinase domain containing
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DEDD death effector domain containing
DNAH17 dynein, axonemal, heavy chain 17
DRD2 dopamine receptor D2
DSCAM Down syndrome cell adhesion molecule
DUSP10 dual specificity phosphatase 10
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EFNA2 ephrin-A2
FCF1 FCF1 rRNA-processing protein
FKBP10 FK506 binding protein 10, 65 kDa
FMOD fibromodulin
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GLP1R glucagon-like peptide 1 receptor
GPR85 G protein-coupled receptor 85
HFE hemochromatosis
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
IGHA1 immunoglobulin heavy constant alpha 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
INHA inhibin, alpha
INO80B INO80 complex subunit B
JAKMIP2 janus kinase and microtubule interacting protein 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLF4 Kruppel-like factor 4 (gut)
LEFTY1 left-right determination factor 1
LOC57399 uncharacterized gastric protein ZA52P
LRP1 low density lipoprotein receptor-related protein 1
LRRC2 leucine rich repeat containing 2
MDFI MyoD family inhibitor
MFSD6 major facilitator superfamily domain containing 6
MN1 meningioma (disrupted in balanced translocation) 1
MX1 MX dynamin-like GTPase 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYO6 myosin VI
NEBL nebulette
NLRP3 NLR family, pyrin domain containing 3
NOTCH2 notch 2
NR1H4 nuclear receptor subfamily 1, group H, member 4
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
PBX1 pre-B-cell leukemia homeobox 1
PCNX pecanex homolog (Drosophila)
PDE4DIP phosphodiesterase 4D interacting protein
PDIA2 protein disulfide isomerase family A, member 2
PER3 period circadian clock 3
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PICK1 protein interacting with PRKCA 1
PIDD1 p53-induced death domain protein 1
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
POMT2 protein-O-mannosyltransferase 2
PTAFR platelet-activating factor receptor
PTCRA pre T-cell antigen receptor alpha
RAG1 recombination activating gene 1
RETN resistin
RIBC2 RIB43A domain with coiled-coils 2
RNF126P1 ring finger protein 126 pseudogene 1
RNF2 ring finger protein 2
SEC23A Sec23 homolog A (S. cerevisiae)
SGSM2 small G protein signaling modulator 2
SIGLEC6 sialic acid binding Ig-like lectin 6
SIRT3 sirtuin 3
SIX2 SIX homeobox 2
SNX13 sorting nexin 13
SPTB spectrin, beta, erythrocytic
SRRT serrate, RNA effector molecule
TAOK3 TAO kinase 3
TBKBP1 TBK1 binding protein 1
TCF3 transcription factor 3
TMED2 transmembrane emp24 domain trafficking protein 2
TRIM25 tripartite motif containing 25
TRIM3 tripartite motif containing 3
TRIP11 thyroid hormone receptor interactor 11
UBE4B ubiquitination factor E4B
ZNF236 zinc finger protein 236
ZNF528 zinc finger protein 528
ZNF75D zinc finger protein 75D

decreased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ADAM29 ADAM metallopeptidase domain 29
ALG3 ALG3, alpha-1,3- mannosyltransferase
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ANXA2P3 annexin A2 pseudogene 3
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
APH1A APH1A gamma secretase subunit
APOH apolipoprotein H (beta-2-glycoprotein I)
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARSA arylsulfatase A
BCAS4 breast carcinoma amplified sequence 4
BICC1 BicC family RNA binding protein 1
C11ORF30 chromosome 11 open reading frame 30
C17ORF70 chromosome 17 open reading frame 70
C3 complement component 3
C5ORF45 chromosome 5 open reading frame 45
C6ORF47 chromosome 6 open reading frame 47
CA9 carbonic anhydrase IX
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CCDC68 coiled-coil domain containing 68
CDK3 cyclin-dependent kinase 3
CEL carboxyl ester lipase
CEP131 centrosomal protein 131kDa
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DENND5B DENN/MADD domain containing 5B
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DLK2 delta-like 2 homolog (Drosophila)
DPF3 D4, zinc and double PHD fingers, family 3
EPN1 epsin 1
EYA4 EYA transcriptional coactivator and phosphatase 4
FKRP fukutin related protein
FOXC1 forkhead box C1
FPGS folylpolyglutamate synthase
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GLTP glycolipid transfer protein
GRAMD1C GRAM domain containing 1C
GUSBP3 glucuronidase, beta pseudogene 3
HDAC11 histone deacetylase 11
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXC5 homeobox C5
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IGSF3 immunoglobulin superfamily, member 3
ISYNA1 inositol-3-phosphate synthase 1
KIAA0319L KIAA0319-like
KLF13 Kruppel-like factor 13
KRT4 keratin 4, type II
LGMN legumain
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LMNB1 lamin B1
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MEGF8 multiple EGF-like-domains 8
MOB3B MOB kinase activator 3B
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
NABP1 nucleic acid binding protein 1
NACAD NAC alpha domain containing
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NINJ1 ninjurin 1
NSUN6 NOP2/Sun domain family, member 6
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PCDHGB5 protocadherin gamma subfamily B, 5
PTGFR prostaglandin F receptor (FP)
RABL6 RAB, member RAS oncogene family-like 6
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF31 ring finger protein 31
SCARA3 scavenger receptor class A, member 3
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC35F6 solute carrier family 35, member F6
STK16 serine/threonine kinase 16
TAGLN transgelin
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TK1 thymidine kinase 1, soluble
TM6SF1 transmembrane 6 superfamily member 1
TMEM8A transmembrane protein 8A
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRABD TraB domain containing
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRPM4 transient receptor potential cation channel, subfamily M, member 4
USB1 U6 snRNA biogenesis 1
USP20 ubiquitin specific peptidase 20
WDR25 WD repeat domain 25
WDR4 WD repeat domain 4
WNT7A wingless-type MMTV integration site family, member 7A
WT1-AS WT1 antisense RNA
ZBED1 zinc finger, BED-type containing 1
ZNF468 zinc finger protein 468
ZNF702P zinc finger protein 702, pseudogene
ZNF721 zinc finger protein 721