SB-202190-7054 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the SB-202190-7054 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABHD14A abhydrolase domain containing 14A
ACVR1B activin A receptor, type IB
ADAP1 ArfGAP with dual PH domains 1
AHDC1 AT hook, DNA binding motif, containing 1
ALMS1 Alstrom syndrome protein 1
APC adenomatous polyposis coli
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ATN1 atrophin 1
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BTD biotinidase
C22ORF46 chromosome 22 open reading frame 46
C7ORF43 chromosome 7 open reading frame 43
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CUEDC1 CUE domain containing 1
CUL7 cullin 7
DNAAF1 dynein, axonemal, assembly factor 1
DUSP4 dual specificity phosphatase 4
ETV5 ets variant 5
FAM184A family with sequence similarity 184, member A
FCHO1 FCH domain only 1
FGFR1 fibroblast growth factor receptor 1
FGL1 fibrinogen-like 1
FLJ11710 uncharacterized protein FLJ11710
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GATA2 GATA binding protein 2
GBP2 guanylate binding protein 2, interferon-inducible
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GON4L gon-4-like (C. elegans)
HOXC10 homeobox C10
HPS4 Hermansky-Pudlak syndrome 4
IFITM1 interferon induced transmembrane protein 1
INO80D INO80 complex subunit D
IQCG IQ motif containing G
JUN jun proto-oncogene
KIF13A kinesin family member 13A
KLHL25 kelch-like family member 25
LRRC61 leucine rich repeat containing 61
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MALT1 MALT1 paracaspase
MCOLN3 mucolipin 3
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
N4BP2L2 NEDD4 binding protein 2-like 2
NCAPH2 non-SMC condensin II complex, subunit H2
NOD1 nucleotide-binding oligomerization domain containing 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OTUD4 OTU deubiquitinase 4
PEX26 peroxisomal biogenesis factor 26
PHKA2 phosphorylase kinase, alpha 2 (liver)
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLXNB1 plexin B1
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RARA retinoic acid receptor, alpha
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF25 ring finger protein 25
RPL13P5 ribosomal protein L13 pseudogene 5
SBF1 SET binding factor 1
SCN1B sodium channel, voltage gated, type I beta subunit
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SETD1A SET domain containing 1A
SIK1 salt-inducible kinase 1
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SNTA1 syntrophin, alpha 1
SPPL2B signal peptide peptidase like 2B
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREK1IP1 SREK1-interacting protein 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SUGP1 SURP and G patch domain containing 1
TADA2A transcriptional adaptor 2A
THAP3 THAP domain containing, apoptosis associated protein 3
TPCN1 two pore segment channel 1
TTC9 tetratricopeptide repeat domain 9
TTLL3 tubulin tyrosine ligase-like family member 3
WDR91 WD repeat domain 91
ZBTB17 zinc finger and BTB domain containing 17
ZKSCAN5 zinc finger with KRAB and SCAN domains 5
ZNF277 zinc finger protein 277
ZNF365 zinc finger protein 365
ZNF589 zinc finger protein 589
ZNF8 zinc finger protein 8
ZSCAN31 zinc finger and SCAN domain containing 31
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
ADAP2 ArfGAP with dual PH domains 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ATAD5 ATPase family, AAA domain containing 5
C11ORF21 chromosome 11 open reading frame 21
C17ORF80 chromosome 17 open reading frame 80
C19ORF73 chromosome 19 open reading frame 73
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C22ORF29 chromosome 22 open reading frame 29
CARTPT CART prepropeptide
CCDC186 coiled-coil domain containing 186
CCDC68 coiled-coil domain containing 68
CCDC85C coiled-coil domain containing 85C
CCNT1 cyclin T1
CEP85 centrosomal protein 85kDa
CEP97 centrosomal protein 97kDa
CGREF1 cell growth regulator with EF-hand domain 1
CLCF1 cardiotrophin-like cytokine factor 1
CPA4 carboxypeptidase A4
CRYBG3 beta-gamma crystallin domain containing 3
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DMTN dematin actin binding protein
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ERCC4 excision repair cross-complementation group 4
EXOC5 exocyst complex component 5
F3 coagulation factor III (thromboplastin, tissue factor)
FBXL2 F-box and leucine-rich repeat protein 2
FBXO3 F-box protein 3
FOS FBJ murine osteosarcoma viral oncogene homolog
GATA4 GATA binding protein 4
GDAP1 ganglioside induced differentiation associated protein 1
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GP6 glycoprotein VI (platelet)
GPR27 G protein-coupled receptor 27
GPRASP1 G protein-coupled receptor associated sorting protein 1
GTF2I general transcription factor IIi
HIST1H2BC histone cluster 1, H2bc
HIST1H3E histone cluster 1, H3e
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
ICK intestinal cell (MAK-like) kinase
IPO8 importin 8
IQSEC2 IQ motif and Sec7 domain 2
ITGA10 integrin, alpha 10
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KCTD20 potassium channel tetramerization domain containing 20
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MBTD1 mbt domain containing 1
MCC mutated in colorectal cancers
MIS18BP1 MIS18 binding protein 1
MPDU1 mannose-P-dolichol utilization defect 1
MRPL44 mitochondrial ribosomal protein L44
MYOZ3 myozenin 3
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NKAIN1 Na+/K+ transporting ATPase interacting 1
NPY1R neuropeptide Y receptor Y1
OSMR oncostatin M receptor
OVGP1 oviductal glycoprotein 1, 120kDa
PAIP2B poly(A) binding protein interacting protein 2B
PCNXL4 pecanex-like 4 (Drosophila)
PELI1 pellino E3 ubiquitin protein ligase 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLA2G10 phospholipase A2, group X
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PRB4 proline-rich protein BstNI subfamily 4
RAB23 RAB23, member RAS oncogene family
RNF31 ring finger protein 31
RNF43 ring finger protein 43
ROM1 retinal outer segment membrane protein 1
RPL23AP7 ribosomal protein L23a pseudogene 7
RSF1 remodeling and spacing factor 1
SCYL2 SCY1-like 2 (S. cerevisiae)
SEC14L2 SEC14-like 2 (S. cerevisiae)
SERTAD3 SERTA domain containing 3
SETD8 SET domain containing (lysine methyltransferase) 8
SH3GLB2 SH3-domain GRB2-like endophilin B2
SIX1 SIX homeobox 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SPRYD7 SPRY domain containing 7
STON1 stonin 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TCP10 t-complex 10
TK1 thymidine kinase 1, soluble
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMC7 transmembrane channel-like 7
TMOD3 tropomodulin 3 (ubiquitous)
TMPRSS6 transmembrane protease, serine 6
TRAIP TRAF interacting protein
TTF2 transcription termination factor, RNA polymerase II
YPEL1 yippee-like 1 (Drosophila)
ZBTB6 zinc finger and BTB domain containing 6
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF37BP zinc finger protein 37B, pseudogene