SB-202190-6909 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the SB-202190-6909 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ACVR1B activin A receptor, type IB
AK2 adenylate kinase 2
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
ARHGAP11A Rho GTPase activating protein 11A
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASB9 ankyrin repeat and SOCS box containing 9
ATM ATM serine/threonine kinase
ATRN attractin
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BEX4 brain expressed, X-linked 4
BRD3 bromodomain containing 3
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BTN2A1 butyrophilin, subfamily 2, member A1
C18ORF25 chromosome 18 open reading frame 25
C3ORF52 chromosome 3 open reading frame 52
CBR4 carbonyl reductase 4
CCDC22 coiled-coil domain containing 22
CCNG2 cyclin G2
CCSER2 coiled-coil serine-rich protein 2
CD302 CD302 molecule
CENPQ centromere protein Q
CLASP2 cytoplasmic linker associated protein 2
CLK1 CDC-like kinase 1
CSRP2 cysteine and glycine-rich protein 2
CUL2 cullin 2
DOCK1 dedicator of cytokinesis 1
DSE dermatan sulfate epimerase
DTNA dystrobrevin, alpha
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ETNK1 ethanolamine kinase 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GCA grancalcin, EF-hand calcium binding protein
GINS3 GINS complex subunit 3 (Psf3 homolog)
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GOLGA8B golgin A8 family, member B
GRB7 growth factor receptor-bound protein 7
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IRF2 interferon regulatory factor 2
JUN jun proto-oncogene
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KLF3 Kruppel-like factor 3 (basic)
LIMCH1 LIM and calponin homology domains 1
LIMK1 LIM domain kinase 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MID1 midline 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NNT nicotinamide nucleotide transhydrogenase
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PGAP1 post-GPI attachment to proteins 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G3 phospholipase A2, group III
PLSCR1 phospholipid scramblase 1
PNISR PNN-interacting serine/arginine-rich protein
PRKCA protein kinase C, alpha
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PTCH1 patched 1
PTK6 protein tyrosine kinase 6
RNMT RNA (guanine-7-) methyltransferase
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SAFB2 scaffold attachment factor B2
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SH3BP2 SH3-domain binding protein 2
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SMC4 structural maintenance of chromosomes 4
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1
SNX1 sorting nexin 1
SOCS5 suppressor of cytokine signaling 5
SOD2 superoxide dismutase 2, mitochondrial
SOX13 SRY (sex determining region Y)-box 13
SPINK5 serine peptidase inhibitor, Kazal type 5
SRI sorcin
SSPN sarcospan
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SUGP1 SURP and G patch domain containing 1
TADA2A transcriptional adaptor 2A
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TFE3 transcription factor binding to IGHM enhancer 3
THBD thrombomodulin
TNK1 tyrosine kinase, non-receptor, 1
TRAK1 trafficking protein, kinesin binding 1
TRAM1 translocation associated membrane protein 1
TSFM Ts translation elongation factor, mitochondrial
UBAP1 ubiquitin associated protein 1
UBAP2L ubiquitin associated protein 2-like
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDR25 WD repeat domain 25
WWP2 WW domain containing E3 ubiquitin protein ligase 2
WWTR1 WW domain containing transcription regulator 1
ZNF606 zinc finger protein 606
ZNF93 zinc finger protein 93

decreased expression

Symbol Name
ADAP2 ArfGAP with dual PH domains 2
AES amino-terminal enhancer of split
AP4M1 adaptor-related protein complex 4, mu 1 subunit
APEH acylaminoacyl-peptide hydrolase
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATG2A autophagy related 2A
AURKB aurora kinase B
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1
C5ORF45 chromosome 5 open reading frame 45
C8ORF33 chromosome 8 open reading frame 33
CDC37 cell division cycle 37
CDT1 chromatin licensing and DNA replication factor 1
CIC capicua transcriptional repressor
CLIC3 chloride intracellular channel 3
CRIP2 cysteine-rich protein 2
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DDA1 DET1 and DDB1 associated 1
DEAF1 DEAF1 transcription factor
DHRS11 dehydrogenase/reductase (SDR family) member 11
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
EDC4 enhancer of mRNA decapping 4
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERI3 ERI1 exoribonuclease family member 3
EXD3 exonuclease 3'-5' domain containing 3
FAAH fatty acid amide hydrolase
FAM118A family with sequence similarity 118, member A
FAM160B2 family with sequence similarity 160, member B2
FAM50A family with sequence similarity 50, member A
GAA glucosidase, alpha; acid
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
HDAC5 histone deacetylase 5
HOXC11 homeobox C11
HS1BP3 HCLS1 binding protein 3
IP6K1 inositol hexakisphosphate kinase 1
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KLHL21 kelch-like family member 21
L2HGDH L-2-hydroxyglutarate dehydrogenase
LHX1 LIM homeobox 1
MAN2C1 mannosidase, alpha, class 2C, member 1
MAP7D1 MAP7 domain containing 1
MED9 mediator complex subunit 9
METTL8 methyltransferase like 8
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MOSPD3 motile sperm domain containing 3
MPDU1 mannose-P-dolichol utilization defect 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTCL1 microtubule crosslinking factor 1
MTHFSD methenyltetrahydrofolate synthetase domain containing
MUC3B mucin 3B, cell surface associated
NDE1 nudE neurodevelopment protein 1
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PGD phosphogluconate dehydrogenase
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PODXL2 podocalyxin-like 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2C phosphatidic acid phosphatase type 2C
PRR3 proline rich 3
PSENEN presenilin enhancer gamma secretase subunit
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PTPRU protein tyrosine phosphatase, receptor type, U
QTRT1 queuine tRNA-ribosyltransferase 1
RAD9A RAD9 homolog A (S. pombe)
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RHOG ras homolog family member G
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF123 ring finger protein 123
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SH3GLB2 SH3-domain GRB2-like endophilin B2
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMG9 SMG9 nonsense mediated mRNA decay factor
SND1-IT1 SND1 intronic transcript 1
SOX12 SRY (sex determining region Y)-box 12
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
TECR trans-2,3-enoyl-CoA reductase
THOC6 THO complex 6
TM7SF2 transmembrane 7 superfamily member 2
TMEM214 transmembrane protein 214
TMUB2 transmembrane and ubiquitin-like domain containing 2
TPST2 tyrosylprotein sulfotransferase 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
UBE2S ubiquitin-conjugating enzyme E2S
UNC119 unc-119 homolog (C. elegans)
UROS uroporphyrinogen III synthase
USP20 ubiquitin specific peptidase 20
WDR60 WD repeat domain 60
ZMAT5 zinc finger, matrin-type 5
ZNF654 zinc finger protein 654
ZNF768 zinc finger protein 768