SB-202190-6882 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the SB-202190-6882 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR1B activin A receptor, type IB
AK2 adenylate kinase 2
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ALPK1 alpha-kinase 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP3B1 adaptor-related protein complex 3, beta 1 subunit
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATM ATM serine/threonine kinase
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
AURKA aurora kinase A
BAX BCL2-associated X protein
BCL2L11 BCL2-like 11 (apoptosis facilitator)
C14ORF105 chromosome 14 open reading frame 105
C19ORF40 chromosome 19 open reading frame 40
C4ORF29 chromosome 4 open reading frame 29
CASP2 caspase 2, apoptosis-related cysteine peptidase
CDV3 CDV3 homolog (mouse)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFLAR CASP8 and FADD-like apoptosis regulator
CNN2 calponin 2
CNR2 cannabinoid receptor 2 (macrophage)
CPT2 carnitine palmitoyltransferase 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CST4 cystatin S
DBT dihydrolipoamide branched chain transacylase E2
DDN dendrin
DENND4C DENN/MADD domain containing 4C
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
ELP6 elongator acetyltransferase complex subunit 6
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
EYA4 EYA transcriptional coactivator and phosphatase 4
FGF4 fibroblast growth factor 4
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLTP glycolipid transfer protein
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GON4L gon-4-like (C. elegans)
GOSR2 golgi SNAP receptor complex member 2
GRTP1 growth hormone regulated TBC protein 1
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GTPBP4 GTP binding protein 4
GUSBP3 glucuronidase, beta pseudogene 3
HMOX1 heme oxygenase 1
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IFT22 intraflagellar transport 22
ITGA8 integrin, alpha 8
JUN jun proto-oncogene
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LOC647070 uncharacterized LOC647070
LRP3 low density lipoprotein receptor-related protein 3
LRRC37A3 leucine rich repeat containing 37, member A3
LRRC40 leucine rich repeat containing 40
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MED6 mediator complex subunit 6
MFN2 mitofusin 2
MLH3 mutL homolog 3
MYL10 myosin, light chain 10, regulatory
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NME6 NME/NM23 nucleoside diphosphate kinase 6
NPPA natriuretic peptide A
OASL 2'-5'-oligoadenylate synthetase-like
PCNX pecanex homolog (Drosophila)
PDAP1 PDGFA associated protein 1
PICK1 protein interacting with PRKCA 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
POLH polymerase (DNA directed), eta
PVT1 Pvt1 oncogene (non-protein coding)
RAB2A RAB2A, member RAS oncogene family
RAB3B RAB3B, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RABGAP1 RAB GTPase activating protein 1
RBPMS RNA binding protein with multiple splicing
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RETN resistin
RIOK3 RIO kinase 3
RNF126P1 ring finger protein 126 pseudogene 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SPATS2L spermatogenesis associated, serine-rich 2-like
SRRT serrate, RNA effector molecule
SS18 synovial sarcoma translocation, chromosome 18
TGOLN2 trans-golgi network protein 2
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRIM16 tripartite motif containing 16
TRIO trio Rho guanine nucleotide exchange factor
TTLL5 tubulin tyrosine ligase-like family member 5
TUBD1 tubulin, delta 1
WSB1 WD repeat and SOCS box containing 1
YIPF5 Yip1 domain family, member 5
ZNF205 zinc finger protein 205
ZNF430 zinc finger protein 430
ZNF652 zinc finger protein 652
ZNF665 zinc finger protein 665
ZNF749 zinc finger protein 749
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALS2CL ALS2 C-terminal like
ANGPT4 angiopoietin 4
ANOS1 anosmin 1
APOL6 apolipoprotein L, 6
ARHGAP5 Rho GTPase activating protein 5
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATP11B ATPase, class VI, type 11B
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
ATP7B ATPase, Cu++ transporting, beta polypeptide
BAG4 BCL2-associated athanogene 4
C19ORF57 chromosome 19 open reading frame 57
C7ORF43 chromosome 7 open reading frame 43
CALCOCO1 calcium binding and coiled-coil domain 1
CCDC85C coiled-coil domain containing 85C
CCDC88C coiled-coil domain containing 88C
CCNO cyclin O
CEMIP cell migration inducing protein, hyaluronan binding
CENPQ centromere protein Q
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CIR1 corepressor interacting with RBPJ, 1
COL21A1 collagen, type XXI, alpha 1
CPOX coproporphyrinogen oxidase
CUL9 cullin 9
CXCL2 chemokine (C-X-C motif) ligand 2
DCAF17 DDB1 and CUL4 associated factor 17
EFNA3 ephrin-A3
EGR2 early growth response 2
ETAA1 Ewing tumor-associated antigen 1
FAM160B2 family with sequence similarity 160, member B2
FAM86C1 family with sequence similarity 86, member C1
FBXL4 F-box and leucine-rich repeat protein 4
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FNDC4 fibronectin type III domain containing 4
FOXD1 forkhead box D1
GDAP2 ganglioside induced differentiation associated protein 2
GHR growth hormone receptor
GPC3 glypican 3
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL6 interleukin 6
ITGA10 integrin, alpha 10
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KDM4D lysine (K)-specific demethylase 4D
KIAA1551 KIAA1551
KIF13A kinesin family member 13A
KLF13 Kruppel-like factor 13
KLHL28 kelch-like family member 28
LOC730101 uncharacterized LOC730101
LRP5L low density lipoprotein receptor-related protein 5-like
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K7CL MAP3K7 C-terminal like
MOXD1 monooxygenase, DBH-like 1
MST1R macrophage stimulating 1 receptor
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYL5 myosin, light chain 5, regulatory
MYO1E myosin IE
NID2 nidogen 2 (osteonidogen)
NME5 NME/NM23 family member 5
NPM3 nucleophosmin/nucleoplasmin 3
PAX9 paired box 9
PGPEP1 pyroglutamyl-peptidase I
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PMCH pro-melanin-concentrating hormone
POLL polymerase (DNA directed), lambda
QSER1 glutamine and serine rich 1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RARS arginyl-tRNA synthetase
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RGS17 regulator of G-protein signaling 17
RHOBTB2 Rho-related BTB domain containing 2
RINT1 RAD50 interactor 1
RNF219 ring finger protein 219
RNF43 ring finger protein 43
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC30A4 solute carrier family 30 (zinc transporter), member 4
SPIDR scaffolding protein involved in DNA repair
STIM1 stromal interaction molecule 1
SUGCT succinyl-CoA:glutarate-CoA transferase
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TPK1 thiamin pyrophosphokinase 1
TPRA1 transmembrane protein, adipocyte asscociated 1
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
USP6 ubiquitin specific peptidase 6
VWA9 von Willebrand factor A domain containing 9
ZBTB25 zinc finger and BTB domain containing 25
ZHX2 zinc fingers and homeoboxes 2
ZNF189 zinc finger protein 189
ZNF280D zinc finger protein 280D
ZNF350 zinc finger protein 350
ZNF571 zinc finger protein 571
ZNF668 zinc finger protein 668
ZNF671 zinc finger protein 671
ZNF816 zinc finger protein 816