Respiratory Distress Syndrome, Adult Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D012128
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Genes

309 genes/proteins associated with the disease Respiratory Distress Syndrome, Adult from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.88009
ALB albumin 2.88009
THBD thrombomodulin 2.88009
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.88009
EDN1 endothelin 1 2.88009
CHPT1 choline phosphotransferase 1 2.88009
IL6 interleukin 6 2.2077
TNF tumor necrosis factor 2.07757
CAT catalase 2.03406
BAX BCL2-associated X protein 2.02571
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.02252
CXCL8 chemokine (C-X-C motif) ligand 8 1.97405
FOSL2 FOS-like antigen 2 1.94996
SOD1 superoxide dismutase 1, soluble 1.93891
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.93521
JUN jun proto-oncogene 1.91944
SOD2 superoxide dismutase 2, mitochondrial 1.91034
IL1B interleukin 1, beta 1.9064
FOS FBJ murine osteosarcoma viral oncogene homolog 1.86253
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.81224
GSR glutathione reductase 1.75817
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.73999
BCL2 B-cell CLL/lymphoma 2 1.73557
EGR1 early growth response 1 1.73332
HMOX1 heme oxygenase 1 1.72988
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.72467
FGF2 fibroblast growth factor 2 (basic) 1.71912
NOS2 nitric oxide synthase 2, inducible 1.71606
IL10 interleukin 10 1.71565
CCL2 chemokine (C-C motif) ligand 2 1.71524
MPO myeloperoxidase 1.71399
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.71379
ICAM1 intercellular adhesion molecule 1 1.70657
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.70224
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.6934
NOS3 nitric oxide synthase 3 (endothelial cell) 1.69082
MAPK3 mitogen-activated protein kinase 3 1.69082
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.67912
MMP9 matrix metallopeptidase 9 1.6789
CCL3 chemokine (C-C motif) ligand 3 1.67547
TP53 tumor protein p53 1.65687
IL1A interleukin 1, alpha 1.6419
DDIT3 DNA-damage-inducible transcript 3 1.61828
MAPK1 mitogen-activated protein kinase 1 1.60851
DUSP1 dual specificity phosphatase 1 1.60688
EGFR epidermal growth factor receptor 1.60337
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.60151
ACHE acetylcholinesterase (Yt blood group) 1.59497
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.58865
IFNG interferon, gamma 1.58771
FOSL1 FOS-like antigen 1 1.58748
PPARG peroxisome proliferator-activated receptor gamma 1.58184
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.57594
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.5678
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 1.55402
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.55035
BDNF brain-derived neurotrophic factor 1.54937
VEGFA vascular endothelial growth factor A 1.54378
MAP2K1 mitogen-activated protein kinase kinase 1 1.54208
TGFA transforming growth factor, alpha 1.53941
CCND1 cyclin D1 1.5382
JUNB jun B proto-oncogene 1.53407
GJA1 gap junction protein, alpha 1, 43kDa 1.52338
NFE2L2 nuclear factor, erythroid 2-like 2 1.52086
XDH xanthine dehydrogenase 1.52061
TFRC transferrin receptor 1.51557
BAK1 BCL2-antagonist/killer 1 1.5143
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.51155
MMP2 matrix metallopeptidase 2 1.50827
NUPR1 nuclear protein, transcriptional regulator, 1 1.50574
ODC1 ornithine decarboxylase 1 1.50423
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.49304
MAPK8 mitogen-activated protein kinase 8 1.49226
TGFB1 transforming growth factor, beta 1 1.48608
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.48582
SFTPB surfactant protein B 1.48428
VCAM1 vascular cell adhesion molecule 1 1.48299
MMP3 matrix metallopeptidase 3 1.47966
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.47762
CYCS cytochrome c, somatic 1.47038
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.46727
SFTPD surfactant protein D 1.46674
CASP12 caspase 12 (gene/pseudogene) 1.46621
GFAP glial fibrillary acidic protein 1.46436
ATF3 activating transcription factor 3 1.45723
ADRB2 adrenoceptor beta 2, surface 1.45089
IL2 interleukin 2 1.44681
INS insulin 1.43974
CREB1 cAMP responsive element binding protein 1 1.43974
GPX1 glutathione peroxidase 1 1.43755
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.43727
MMP1 matrix metallopeptidase 1 1.42535
CTGF connective tissue growth factor 1.42535
GSK3B glycogen synthase kinase 3 beta 1.42183
LEP leptin 1.41884
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.41829
G6PD glucose-6-phosphate dehydrogenase 1.41721
CXCL2 chemokine (C-X-C motif) ligand 2 1.41586
IL4 interleukin 4 1.40925
BIRC5 baculoviral IAP repeat containing 5 1.40677
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.40148
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.39785
TGFB2 transforming growth factor, beta 2 1.39646
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.39507
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.39394
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.38863
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 1.38015
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.37619
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.37532
DIABLO diablo, IAP-binding mitochondrial protein 1.37303
ATF4 activating transcription factor 4 1.37275
BID BH3 interacting domain death agonist 1.36706
GSTM1 glutathione S-transferase mu 1 1.36619
LIF leukemia inhibitory factor 1.36591
TIMP2 TIMP metallopeptidase inhibitor 2 1.36161
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.36161
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.35991
BCL2L1 BCL2-like 1 1.35934
PCNA proliferating cell nuclear antigen 1.35906
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.35676
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.35357
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.34926
FAS Fas cell surface death receptor 1.3484
PLAU plasminogen activator, urokinase 1.34459
PARP1 poly (ADP-ribose) polymerase 1 1.34314
F2 coagulation factor II (thrombin) 1.34169
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.34111
CASP4 caspase 4, apoptosis-related cysteine peptidase 1.33909
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.33701
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.33701
GNAS GNAS complex locus 1.33701
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.33553
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.33228
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.32993
RXRA retinoid X receptor, alpha 1.32964
BIRC3 baculoviral IAP repeat containing 3 1.32696
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.32696
CSF1R colony stimulating factor 1 receptor 1.3228
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.31416
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.31
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.31
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.30421
CD36 CD36 molecule (thrombospondin receptor) 1.30147
TIMP1 TIMP metallopeptidase inhibitor 1 1.30087
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.30026
EPO erythropoietin 1.29843
NQO1 NAD(P)H dehydrogenase, quinone 1 1.29843
TLR4 toll-like receptor 4 1.29471
RGS4 regulator of G-protein signaling 4 1.29225
FASLG Fas ligand (TNF superfamily, member 6) 1.28672
GADD45A growth arrest and DNA-damage-inducible, alpha 1.28579
MAP2K2 mitogen-activated protein kinase kinase 2 1.28518
BIRC2 baculoviral IAP repeat containing 2 1.28518
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.28518
PECAM1 platelet/endothelial cell adhesion molecule 1 1.27813
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.2707
ATF6 activating transcription factor 6 1.26978
COL1A1 collagen, type I, alpha 1 1.26763
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.26669
GDNF glial cell derived neurotrophic factor 1.26452
TH tyrosine hydroxylase 1.26298
HSPB1 heat shock 27kDa protein 1 1.26052
POR P450 (cytochrome) oxidoreductase 1.25682
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 1.25525
CXCR4 chemokine (C-X-C motif) receptor 4 1.25369
XBP1 X-box binding protein 1 1.25214
E2F1 E2F transcription factor 1 1.25028
JAK1 Janus kinase 1 1.24935
APP amyloid beta (A4) precursor protein 1.24781
LCN2 lipocalin 2 1.24718
MAPK9 mitogen-activated protein kinase 9 1.24528
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.24338
HSF1 heat shock transcription factor 1 1.23488
DDIT4 DNA-damage-inducible transcript 4 1.23424
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 1.22727
IL12B interleukin 12B 1.22696
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.22599
GSN gelsolin 1.22534
ALDOA aldolase A, fructose-bisphosphate 1.2208
PRKCD protein kinase C, delta 1.22016
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.20946
ACKR3 atypical chemokine receptor 3 1.20848
PPARA peroxisome proliferator-activated receptor alpha 1.20622
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 1.20526
CCL5 chemokine (C-C motif) ligand 5 1.20295
GUCY1B3 guanylate cyclase 1, soluble, beta 3 1.2013
SIRT1 sirtuin 1 1.19966
FGFR2 fibroblast growth factor receptor 2 1.19246
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.18948
SPP1 secreted phosphoprotein 1 1.18259
NGF nerve growth factor (beta polypeptide) 1.18259
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 1.18226
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 1.18093
JUND jun D proto-oncogene 1.17827
MAP2K3 mitogen-activated protein kinase kinase 3 1.17761
MAPK10 mitogen-activated protein kinase 10 1.17431
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.17431
CCL20 chemokine (C-C motif) ligand 20 1.17431
PLAT plasminogen activator, tissue 1.17067
IL18 interleukin 18 1.17067
PDGFB platelet-derived growth factor beta polypeptide 1.17034
ARG1 arginase 1 1.16833
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.16203
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.16137
SMAD3 SMAD family member 3 1.15899
PTK2 protein tyrosine kinase 2 1.15695
THBS1 thrombospondin 1 1.15695
MCL1 myeloid cell leukemia 1 1.15526
CD40LG CD40 ligand 1.14989
CAPN1 calpain 1, (mu/I) large subunit 1.14989
FABP1 fatty acid binding protein 1, liver 1.14781
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.1461
RB1 retinoblastoma 1 1.14268
CFLAR CASP8 and FADD-like apoptosis regulator 1.14234
ANGPTL4 angiopoietin-like 4 1.14064
SST somatostatin 1.13862
CDK4 cyclin-dependent kinase 4 1.13655
MGST1 microsomal glutathione S-transferase 1 1.13518
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.13415
HSPA1A heat shock 70kDa protein 1A 1.13415
EIF2A eukaryotic translation initiation factor 2A, 65kDa 1.13279
GSTP1 glutathione S-transferase pi 1 1.13245
MAOA monoamine oxidase A 1.1253
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 1.12495
NGFR nerve growth factor receptor 1.12461
ESR1 estrogen receptor 1 1.12391
CNR1 cannabinoid receptor 1 (brain) 1.12014
AKT2 v-akt murine thymoma viral oncogene homolog 2 1.11945
CAPN2 calpain 2, (m/II) large subunit 1.11945
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.11843
EGF epidermal growth factor 1.11673
MMP13 matrix metallopeptidase 13 1.11673
CTSB cathepsin B 1.10872
TXNRD1 thioredoxin reductase 1 1.10665
TGFBR1 transforming growth factor, beta receptor 1 1.10665
SFTPA1 surfactant protein A1 1.10596
ACTB actin, beta 1.10388
CPT1A carnitine palmitoyltransferase 1A (liver) 1.10246
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 1.1014
NCF2 neutrophil cytosolic factor 2 1.1014
CAV1 caveolin 1, caveolae protein, 22kDa 1.10069
PDK1 pyruvate dehydrogenase kinase, isozyme 1 1.09927
CD14 CD14 molecule 1.09927
PSAT1 phosphoserine aminotransferase 1 1.09927
FN1 fibronectin 1 1.09857
CD44 CD44 molecule (Indian blood group) 1.09751
FST follistatin 1.09436
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 1.09436
CTSD cathepsin D 1.09154
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.08549
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.08549
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 1.08442
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 1.08407
CD86 CD86 molecule 1.08091
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.07947
IL13 interleukin 13 1.07804
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 1.07768
ERBB4 erb-b2 receptor tyrosine kinase 4 1.07589
CKB creatine kinase, brain 1.07553
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.07518
KLF4 Kruppel-like factor 4 (gut) 1.0734
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.0734
REN renin 1.07234
OTC ornithine carbamoyltransferase 1.07199
ATF2 activating transcription factor 2 1.06917
MT2A metallothionein 2A 1.06515
NOX4 NADPH oxidase 4 1.06442
SRGN serglycin 1.06406
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.0637
AGPAT9 1-acylglycerol-3-phosphate O-acyltransferase 9 1.06008
SFTPC surfactant protein C 1.05685
NOTCH1 notch 1 1.05573
PRKCA protein kinase C, alpha 1.05386
ADORA3 adenosine A3 receptor 1.05274
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 1.05163
INHBA inhibin, beta A 1.05163
MMP14 matrix metallopeptidase 14 (membrane-inserted) 1.04941
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.04868
TAGLN transgelin 1.04721
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.04163
SOD3 superoxide dismutase 3, extracellular 1.04126
PDK4 pyruvate dehydrogenase kinase, isozyme 4 1.03493
MT1G metallothionein 1G 1.03493
IRF1 interferon regulatory factor 1 1.03493
IL5 interleukin 5 1.03382
LOX lysyl oxidase 1.03308
BAD BCL2-associated agonist of cell death 1.03235
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.03159
TRADD TNFRSF1A-associated via death domain 1.03159
S100A9 S100 calcium binding protein A9 1.03122
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.03084
CREBBP CREB binding protein 1.02933
PGF placental growth factor 1.02783
COL5A2 collagen, type V, alpha 2 1.02783
PPARD peroxisome proliferator-activated receptor delta 1.02746
CES2 carboxylesterase 2 1.02746
STAT1 signal transducer and activator of transcription 1, 91kDa 1.02708
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.02708
NPPA natriuretic peptide A 1.02447
CLU clusterin 1.02447
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.02151
TSC2 tuberous sclerosis 2 1.02151
CD40 CD40 molecule, TNF receptor superfamily member 5 1.01587
IL3 interleukin 3 1.01474
PRKCE protein kinase C, epsilon 1.01399
PRKCB protein kinase C, beta 1.01212
TIMP3 TIMP metallopeptidase inhibitor 3 1.01212
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 1.01137
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.01025