Renal Insufficiency, Chronic Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

164 genes associated with the Renal Insufficiency, Chronic phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
ACE angiotensin I converting enzyme
ACTN4 actinin, alpha 4
ADD1 adducin 1 (alpha)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRB2 adrenoceptor beta 2, surface
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AKAP10 A kinase (PRKA) anchor protein 10
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALPK1 alpha-kinase 1
ANXA5 annexin A5
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APOL1 apolipoprotein L, 1
APOL3 apolipoprotein L, 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCHE butyrylcholinesterase
BLK BLK proto-oncogene, Src family tyrosine kinase
C3 complement component 3
CARD11 caspase recruitment domain family, member 11
CASR calcium-sensing receptor
CAT catalase
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD40LG CD40 ligand
CETP cholesteryl ester transfer protein, plasma
CFHR5 complement factor H-related 5
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A4 collagen, type IV, alpha 4
COL4A5 collagen, type IV, alpha 5
COMT catechol-O-methyltransferase
CPB2 carboxypeptidase B2 (plasma)
CST3 cystatin C
CTGF connective tissue growth factor
CTSG cathepsin G
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYBA cytochrome b-245, alpha polypeptide
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
EDN1 endothelin 1
ELN elastin
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP2 fatty acid binding protein 2, intestinal
FAM78B family with sequence similarity 78, member B
FGB fibrinogen beta chain
FOXC2 forkhead box C2
FTO fat mass and obesity associated
GCK glucokinase (hexokinase 4)
GCKR glucokinase (hexokinase 4) regulator
GCLM glutamate-cysteine ligase, modifier subunit
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GHSR growth hormone secretagogue receptor
GJA4 gap junction protein, alpha 4, 37kDa
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GPX1 glutathione peroxidase 1
GRHL2 grainyhead-like 2 (Drosophila)
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
HBB hemoglobin, beta
HFE hemochromatosis
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
HSPA8 heat shock 70kDa protein 8
IL10 interleukin 10
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
IRAK1 interleukin-1 receptor-associated kinase 1
IRF5 interferon regulatory factor 5
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KL klotho
LDLR low density lipoprotein receptor
LIMK1 LIM domain kinase 1
LIPC lipase, hepatic
LRP2 low density lipoprotein receptor-related protein 2
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LTA4H leukotriene A4 hydrolase
MGP matrix Gla protein
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MOK MOK protein kinase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MYH9 myosin, heavy chain 9, non-muscle
NOS3 nitric oxide synthase 3 (endothelial cell)
NPY neuropeptide Y
OR13G1 olfactory receptor, family 13, subfamily G, member 1
ORAI1 ORAI calcium release-activated calcium modulator 1
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PALB2 partner and localizer of BRCA2
PALLD palladin, cytoskeletal associated protein
PARP1 poly (ADP-ribose) polymerase 1
PAX4 paired box 4
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE4D phosphodiesterase 4D, cAMP-specific
PDX1 pancreatic and duodenal homeobox 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PON1 paraoxonase 1
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
REN renin
RETN resistin
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
SELE selectin E
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH2B3 SH2B adaptor protein 3
SHROOM3 shroom family member 3
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
SOD2 superoxide dismutase 2, mitochondrial
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
STAT4 signal transducer and activator of transcription 4
TGFB1 transforming growth factor, beta 1
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TMPRSS6 transmembrane protease, serine 6
TNF tumor necrosis factor
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNIP1 TNFAIP3 interacting protein 1
TSC1 tuberous sclerosis 1
TSC22D1 TSC22 domain family, member 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
UMOD uromodulin
UMODL1 uromodulin-like 1
UTS2 urotensin 2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VKORC1 vitamin K epoxide reductase complex, subunit 1
WRN Werner syndrome, RecQ helicase-like